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Biomedical subjects

F Hattab

Publications and source records attributed to F Hattab.

14 recordsLinked to original sources
PubMed1986

The diffusion in vitro of fluoride and chlorhexidine in the enamel of human deciduous and permanent teeth.

The permeability of human dental enamel was studied by following the diffusion of [51Cr]-ethylenediaminetetraacetate (EDTA), F and [14C]-chlorhexidine using two-chamber diffusion cells. The [51Cr]-EDTA served as a marker to control the change in enamel permeability during the diffusion process. An average increase in enamel permeability of about 1.6-fold was recorded following the initial diffusion of the test compounds in the deciduous and permanent enamel. The permeability of deciduous enamel was much higher than that of permanent enamel. For [51Cr]-EDTA and [14C]-chlorhexidine, the average diffusion coefficient was about 30-fold more than in permanent enamel; for F it was 150-fold more. The difference was statistically significant (p less than 0.001). Co-administration of F and [14C]-chlorhexidine showed a higher diffusion rate for each compound than when separately diffused. Whether this is due to a synergetic effect or to increased enamel permeability following the initial diffusion of the compound, or both, is still uncertain.

Adolescent↗
PubMed1985

Diffusion of fluoride from alginate compared with other topical fluoride agents.

A two-chamber diffusion cell has been employed to monitor the diffusion of fluoride (F) from F-containing agents. The F which diffused from fluoridated alginate-base formula, F-containing gel (Gelution) and varnish (Duraphat) was determined within the first 6 or 20 min in unstirred conditions. A comparative analysis of the data showed that the alginate-base formula was efficient in releasing F. The results also indicate that the diffused F was not directly related to the total F content in the products or the bulkiness of the test specimens. It is obvious that the physicochemical properties of the products play a determining role in the release of F.

Acidulated Phosphate Fluoride↗
PubMed1984

Effect of fluoride-containing alginates and gels on the acid resistance of demineralized human enamel.

A series of in vitro studies were carried out to determine the effect of commerically available alginate impression materials and gels on enamel solubility. This was performed by 4-min topical application of the tested products on partially demineralized enamel surfaces. The difference in the amounts of calcium and phosphorus dissolved in acetate buffer before and after topical treatment was considered a measure of the reduction in enamel solubility. All topically applied materials except APF-gel (Gelution) exerted a considerable reduction in enamel solubility ranging between 41.4% and 61.5% in 0.2 M acetate buffer. Successive enamel solubility tests in weak acetate buffer (0.01 M) showed that Gelution was inferior to the other tested products. No simple relationship exists between the fluoride content of these products and their antisolubility effect.

Acidulated Phosphate Fluoride↗
PubMed1984

Micro-determination of phosphate in enamel biopsy samples using the malachite green method.

A simple and sensitive malachite green method was adapted for the determination of phosphate in enamel demineralizing solutions. Comparison with other methods indicates that malachite green was about 60 times more sensitive than Fiske and Subbarow's method and 10 times more than that of Chen et al. The high sensitivity of this method allows very small biopsy samples to be used. The linearity is good between the tested range of 0.025-3.0 mM P. The relative standard deviation was low and amounted to 1.4% in duplicate determinations. No statistical differences in phosphate concentration of enamel biopsy samples determined by the three methods were found. Fluoride concentration up to 80 micrograms/ml did not interfere with phosphate determined by the malachite green. For sampling enamel, the acid-etch technique was used, and the fluoride concentration at successive demineralization runs was monitored using fluoride-ion electrode.

Calcium↗
PubMed1981

Absorption of fluoride following inhalation and ingestion of alginate impression materials.

The fluoride (F) contents of ten alginate impression materials in powder form, were found to range from 0.44% to 2.42%. Plasma F concentrations showed no appreciable changes in five dental personnel exposed to aerosols of these powders during routine clinical work. Elevated plasma F levels (120-158 ng/ml) were recorded after ingesting 2 g (approximately 10 mg F) of Zelgan normal-set alginate. The bioavailability of F from the alginate was about 55% of the total F in the administered dose. It is concluded that routine clinical exposure to alginate does not cause any important change in plasma F levels, whereas accidental swallowing of alginate raises the plasma F level significantly.

Adult↗
PubMed1980

The release of fluoride from two products of alginate impression materials.

The purpose of this study was to determine the fluoride content of two products of alginate and the possible fluoride transfer to the teeth, saliva and blood. The total fluoride content of Zelgan normal-set and Kerr alginate fastset powder was assayed by direct diffusion and diffusion of the ash. The soluble fluoride leaching out in water over 24 hour was also determined. The results show that the fluoride contents of Zelgan and Kerr alginate powders are about 1.9% and 1.5% fluoride, respectively. Of the fluoride present in Zelgan and Kerr approximately 6.5% and 5.8%, respectively, leached out in 400 ml deionized water. The fluoride uptake was estimated in two adjacent enamel layers each approximately 7 micrometers thick, using 10 teeth exposed for 5 minutes and 18 h to the alginate gel (Zelgan). The results of acid etch microsamplings indicate a significant increase in the fluoride concentration of the first enamel layer after both 5 min and 18 h exposure. Fluoride uptake within the second enamel layer was insignificant, however. Fluoride transfer to the oral saliva and to the blood was evident after impression taking.

Alginates↗
PubMed1978

[Arginine aspartate effects on rabbit acute and chronic alcoholization (author's transl)].

Oral arginine aspartate treatment effects (acute administration: 1 g 30 minutes after load, chronic administration: 0.33 g a day during 9 months) are researched on rabbit acute alcoholizing load (1 ml alcohol 40 degrees/100 g) and alcohol chronic intoxication (0,5 ml alcohol 40 degrees/100 g a day during 9 months). 1) Arginine aspartate acute administration decreases 6 h alcoholemic rates, when compared to normals T + t receiving an equal nutritional placebo at 30 minutes (p < 0.01), without 1 h peak modification, and increases ethyloxydation coefficient (p < 0,01). Aspartate, arginine or pyruvate isolated administration at 30 minutes, increases ethyloxydation coefficient in following order: arginine (no significant difference with T + t), pyruvate + arginine and pyruvate (limit p 0,10 or p < 0,05), aspartate (p < 0,05). It is maximum with arginine aspartate (p < 0.01). 2) Arginine aspartate chronic administration partially reduces hyperalcoholemy (p < 0,01) and hypertriglyceridemy (p < 0.10), strongly increased in non treated alcoholized (p < 0.01). Transaminases rates, which remained about normal in non treated alcoholized, decrease under same time alcoholized (p < 0,10) and 0 values (p < 0.05). Hepatic histology shows, after 9 months, in alcoholized group, inflammatory oedema with some cellular damage, without steatosis. Arginine aspartate seems to provoke some hepatic protection with cellular regeneration.

Alcoholic Intoxication↗
PubMed1976

[Effect of subacute fluorine poisoning in the rabbit on fluorine and phosphorus-calcium metabolism and on radiography of the skeleton].

Rabbit subacute fluoride intoxication effects (21,4 mg a day for 10 months) are researched on fluor, calcium and phosphorus metabolism and on skeletal radiology. Fluoremy increase (p less than 0.05) and there is a strong fluor retention (p less than 0.01), due to fluor digestive utilization coefficient increase (p less than 0.05), in spite of relative hyperfluorury (p less than 0.05). Calcemy decreases (p less than 0.01), but phosphatemy and alkaline phosphatasemy do not vary but a little. Calcium and phosphorus balances become negative (p less than 0.05), due to calcium digestive utilization coefficient inversion (p less than 0.05) and phosphorus digestive utilization coefficient decrease (p less than 0.05) and hypercalciury (p less than 0.05) and hyperphosphatury (p less than 0.05) with phosphorus renal reabsorption coefficient decrease (p less than 0.05). Some skeletal radiological abnormalities appear on rachis and limbs.

Alkaline Phosphatase↗