Biomedical subjects

F Haverkamp

Publications and source records attributed to F Haverkamp.

At least 55 records · Page 3Linked to original sources

PubMed1988

Plasma growth hormone-releasing hormone levels in type 1 (insulin-dependent) diabetic children following a mixed meal.

Following a mixed meal, plasma hormone responses were measured in four type 1 diabetic children and in eight short normal children. Between 60 and 150 min after ingestion of the mixed meal there was a significant increase in circulating growth hormone-releasing hormone values both in diabetic and in normal children. Mean plasma GHRH peak values were not different between diabetic patients (27.0 +/- 3.9 ng/l) and controls (24.6 +/- 4.9 ng/l). No time relationship to spontaneous growth hormone peaks was observed. Whereas normal children showed a characteristic biphasic plasma somatostatin response, somatostatin plasma levels in diabetic children did not change. In normal children plasma insulin values increased between 30 and 150 min, but remained unchanged in type 1 diabetic patients. Blood glucose response was more pronounced in diabetic children than in short normal children. These results indicate that circulating growth hormone-releasing hormone does not play a dominant role in the regulation of insulin and somatostatin.

Adolescent↗

PubMed1988

Rapid effect of intravenous growth hormone (GH)-releasing hormone 1-44 on plasma GH levels in children.

Growth hormone releasing hormone (GHRH)-testing was performed in 24 short normal children (16 male, 8 female). Before and after administration of GHRH1-44 (1 microgram/kg body weight i.v.) blood samples for growth hormone (GH) determination were drawn at -30, 0, 1, 2, 3, 4, 6, 8, 10, 15, 30, 45, 60, and 90 min. Plasma GH increase was apparent 1 min after injection and in 12 patients (7 female) peak plasma GH values were reached within 15 min. In all patients plasma GH levels were greater than 10 ng/ml within the first 8 min following GHRH injection, but in 4 patients this level was not attained when considering only GH values obtained after 15 min. These results demonstrate the capability of the pituitary to rapidly secrete GH in response to GHRH1-44 in children. Therefore, in this age group blood samples for GH determination should be taken earlier when testing with GHRH1-44.

Adolescent↗

PubMed1988

Hydrops fetalis as an indication for prenatal chromosome analysis with the example of the diagnosis of a duplication 15q11 and 17q25 due to a familial translocation 15/17.

A child with a combined trisomy 15q11 and 17q25 shows the typical phenotype of partial duplication 17q. The male fetus developed in the 3rd trimenon of pregnancy a nonimmune hydrops fetalis (NIHF). Analysing the chromosomes of 54 cases with NIHF during the 2nd and 3rd trimenon and after birth we found chromosomal abnormalities in 33% of them.

Cells, Cultured↗

PubMed1987

Plasma levels of growth hormone-releasing hormone and somatostatin in response to a mixed meal and during sleep in children.

Following a mixed meal, plasma levels of GHRH, GH, SRIH and insulin were measured in 7 prepubertal children with constitutional delay of growth and adolescence (CDGA) and in 3 children with proven GH-deficiency which responded to GHRH-injection. In children with CDGA, plasma levels of GHRH increased between 60 and 120 min (10.1 +/- 1.2 ng/l vs 25.5 +/- 4.4 ng/l; P less than 0.01). Although no GH increase occurred in patients with GH-deficiency, their plasma GHRH increases were comparable to those in CDGA children. No time relationship was present between circulating GHRH and GH, SRIH, or insulin, nor was there any correlation between their integrated hormone response areas. Sleep-induced plasma GHRH, GH and SRIH values were determined in 10 prepubertal children with CDGA. Spontaneous variations of plasma GHRH and GH values occurred with no temporal or quantitative relationship. SRIH values did not change during nocturnal sleep. In one child with GH-deficiency, comparable GHRH plasma fluctuations occurred, although GH values were all below 1 microgram/l. Our results support the concept that circulating GHRH does not only represent hypothalamic GHRH, but derives mainly from extrahypothalamic sources, possibly from the gastrointestinal tract.

Adolescent↗

PubMed1983

Is there an increase of reproductive rates in schizophrenics? II. An investigation in Nordbaden (SW Germany): methods and description of the patient sample.

For an investigation on the question of whether fertility rates of schizophrenics have been increasing in recent times, two cohorts of patients were defined on an epidemiological basis. The patients were first admissions during either 1949-50 (n = 183) or 1965-67 (n = 228). The conditions of case definition as well as their demographic and psychiatric characteristics are described. These data are necessary for the evaluation of reproductive rates observed in the patient sample. Furthermore, the two cohorts of patients may be of general interest, because they comprise patients first admitted to a hospital who were completely ascertained in a certain region and time period. They reflect certain changes in hospitalization practice in Germany.

Adult↗

PubMed1983

Is there an increase of reproductive rates in schizophrenics? III. An investigation in Nordbaden (SW Germany): results and discussion.

Two cohorts of schizophrenic patients admitted to a psychiatric hospital for the first time either during 1949-50 or 1965-67 were compared with matched controls for reproductive rates before and 13 years after onset of psychosis. Patients of both admission periods had reduced marriage rates. After onset of the disease the rate of reproduction was decreased in males of both periods, but not in females. Patients of both periods did not differ from control values with respect to marital fertility. It has repeatedly been reported that fertility of schizophrenics has been increasing in recent times. Comparison of total reproduction, rate of marriage and marital fertility in patients of the two admission periods and matched controls did not yield any evidence for increasing rates. Instead, the results favour the idea that the patients parallel at a lower level the general decline of birth rates observed in Western Germany.

Adult↗

PubMed1982

Is there an increase of reproductive rates in schizophrenics? I. Critical review of the literature.

It is well-known that the fertility of schizophrenic patients, particularly males, is below the population average. The main measures of fertility (reproductivity) are marriage rate, marital fertility, and rate of reproduction. A review of the literature reveals the rate of reproduction of schizophrenic patients to be 30% to 80% of the general population, the reduction being mainly due to reduced probability of marriage. At least one investigation presented evidence for an increase in marriage rate and rate of reproduction in schizophrenic patients relative to the general population in recent time. If this increase were to be confirmed it would undoubtedly have practical as well as theoretical implications. The hypothesis of a compensatory higher fertility of healthy relatives of schizophrenics based on a physiological advantage is empirically unproven. Additionally, the concept of a balanced polymorphism in schizophrenia rests on a superficial analogy with Mendelian traits.

Female↗

PubMedDate not supplied

[Processes of body perception and their therapeutic use in pediatrics. From nonspecific relaxation therapy to training to recognize disease-specific symptoms].

Focussing on processes of body perception is a major pathway of relaxation therapies (progressive relaxation, autogenic training, guided imagery, hypnotherapy, biofeedback). Traditionally its application has been related to psychosomatic and psychotherapeutic indications. Beyond this classical approach, recent behavioral medicine has emphasized the relevance of interoception processes and adequate attribution patterns concerning bodily sensations as a major source of adequate coping and self-management with somatic illness. Clinical application may refer to an improved cognitive-behavioral pain management in disease and treatment related conditions. Especially children and adolescents suffering from chronic conditions that may exacerbate rapidly may benefit from an education approach that teaches them to perceive their disease-related complaints and symptoms accurately and to attribute them correctly. A precise, panic-free and immediate symptom recognition of sudden airway obstruction is an important precondition of adequate coping with acute asthma crisis and starting risk orientated antiasthmatic treatment. In a similar way, the child with diabetes mellitus may identify early signs of hypoglycemia by self-observation, recognition and discrimination of physical, vegetative and psychological indicators of blood glucose decline that enable the child to take appropriate countermeasures. Other childhood disorders that offer chances for symptomatic self-monitoring and self-control comprise atopic dermatitis or epileptic seizures. Training young patients in precise symptom recognition may not only empower them in handling acute crisis but also strengthen global development of autonomy, control beliefs, self-responsibility and self-esteem.

Asthma↗

PubMedDate not supplied

[Methodological perspectives for the assessment of adaptation in chronic diseases, exemplified by asthma bronchiale in childhood].

BACKGROUND: Regarding the measurement of psychosocial adaptation due to chronic diseases in childhood and adolescence, there is a shift from a more reductionist and biomedical oriented disease-model towards a more integrated, biopsychosocial view of chronic diseases. The three paradigms in measuring psychosocial adaptation (psychopathology, coping, health related quality of life) will be discussed at the example of corresponding empirical studies in children with asthma bronchiale. The psychopathology-oriented research emphasizes the risk of the induced psychopathological comorbidity, whereas the more coping-oriented paradigm primarily includes the dynamic process of the perceived stress and the corresponding coping efforts due to a chronic disease. The third paradigm, the quality of life paradigm, sets its main focus on the subjective view of the chronically ill subject. CONCLUSIONS: In future studies, all three paradigms--each measuring different aspects of psychosocial adaptation--should be simultaneously included to come to a more complex view of adaptation in chronic diseases in general and asthma bronchiale in particular.

Adaptation, Psychological↗

PubMedDate not supplied

[Achievement motivation in children with migraine and their healthy siblings].

QUESTIONS: Psychosocial variables like stress or a high achievement motivation are discussed as a possible contributory factor to an attack in migraine. The aim of our study was to examine, whether children with migraine may be at risk for impaired achievement motivation. PATIENTS/METHODS: 37 children with migraine and their 17 non-affected siblings, were examined by means of an especially developed test for achievement motivation and by the Kaufman-Assessment-Battery for Children (K-ABC). RESULTS: There were no significant differences in achievement motivation and cognition between both groups. Children with migraine and their siblings demonstrated a neurocognitive performance within the average normal test range. There was a slight positive correlation between an atypical achievement motivation and the duration of migraine attacks. CONCLUSION: In general there are no signs of a pathologically elevated achievement motivation in children with migraine, but we found evidence that there might be a subgroup of patients, within whom an atypical achievement motivation might serve as a trigger variable, and who might profit from relaxation techniques and psychological-educational counselling.

Child↗

PubMedDate not supplied

[Genetic aspects of Crohn disease and ulcerative colitis. Empirical risk of recurrence and case presentation].

During the last decades Morbus Crohn and ulcerative Colitis, both chronic inflammatory bowel diseases, show increasing incidence rates. The etiology of the diseases remains unclear. The well known familial occurrence of these diseases will create an increasing demand for medical, psychological and genetic counselling in face of the increasing incidence. The recurrence risks for close relatives will be presented and discussed. An example of Crohn's disease in two twin-siblings illustrates the familial occurrence and underlines the usefulness of being aware of possible recurrence in close relatives.

Child↗

PubMedDate not supplied

[Direct genotype analysis in congenital myotonic dystrophy with an unusual family anamnesis].

We report a case of congenital myotonic dystrophy (CMD) in which not only the mother but also the paternal family is affected by myotonic dystrophy (DM). Clinical symptoms consisted of poor spontaneous movements, typical facial appearance, respiratory insufficiency attributable to diaphragmatic weakness, feeding difficulties due to impaired gastrointestinal tract motility and poor sucking, joint contractures and thin ribs. She died at 7 month of age, still ventilated, from aspiration pneumonia. By employing molecular genetic methods we were able to show that the affected child was not homozygous for the DM gene.

Electromyography↗

PubMedDate not supplied

[Neurometabolic diseases. References for classification, clinical aspects and diagnostic procedures].

Diseases caused by neuro-metabolic or neuro-degenerative disorders often lead to diagnostic difficulties, because of their rarity and numerous quantity. The present report tries to combine older classifications according to anatomic aspects with the newer ones underlying biochemical-functional points of view. Then the most important cardinal symptoms in a synoptic demonstration are put in relation to the most considerable neuro-metabolic disorders. Tables concerning age-related diseases and informations on diagnostic methods of importance are presented.

Brain Diseases, Metabolic↗

PubMedDate not supplied

[7-week-old infant with a hydrolethalus syndrome: case report, differential diagnosis and literature review].

We report on an 7 weeks old male infant with hydrocephalus internus, dysplastic low-set ears, micrognathia, vitium cordis, hypogenitalism, and polyhydramnios in pregnancy. The variability of the Hydrolethalus syndrome will be demonstrated. Our patient shows, that this syndrome is not a lethal in all cases. We report on an 7 weeks old male infant with hydrocephalus internus, dysplastic low-set ears, micrognathia, vitium cordis, hypogenitalism, and polyhydramnios in pregnancy.

Abnormalities, Multiple↗

PubMedDate not supplied

[Non-immunologic hydrops fetalis (NIHF)--case report of double partial trisomy 15q and 17q resulting from familial translocation 15/17 and cytogenetic findings in 50 cases with hydrops fetalis].

We report the first case of non-immune hydrops fetalis (NIHF) with trisomy 15q11/17q22.5 resulting from a familial translocation 15/17. Furthermore the cytogenetic findings of 50 cases with hydrops fetalis are presented. Of the 30 cytogenetic analyzable cases 7 showed chromosomal abnormalities (4x45,X; 2x47,XY,+21; 1x47,XY,+13). In every case of NIHF a chromosomal analysis should be performed if possible from different tissues.

Chromosomes, Human, Pair 15↗

PubMedDate not supplied

[Subacute sclerosing panencephalitis (SSPE) as differential diagnosis in severe personality changes and ataxia--case report and literature review].

An 8 year old girl presented with progressive change of personality and spastic ataxia since 4 weeks. A year before she had developed focal grand-mal-seizures; at this time laboratory and radiologic findings were normal. The EEG on admission demonstrated marked changes with partially focal, partially generalized hypersynchronic activity, but no SSPE-typical Radermecker-complexes. There were no cells in the cerebrospinal fluid (CSF), a slightly increased level of protein and a normal glucose. Isoelectric focusing showed predominantly measles-specific oligoclonal IgG bands in the CSF. In the magnetic resonance tomography multiple focal white matter lesions in the basal ganglia as well as in cortical and occipitoparietal regions could be seen. At the age of two the girl had suffered from measles, the child didn't receive any vaccination. The combination of history, CSF-, MRI-results and EEG lead to the diagnosis of subacute sclerosing panencephalitis (SSPE). After 3 months the clinical and radiological abnormalities had markedly increased. On the background of this history SSPE should be considered as differential diagnosis in patients with changes of personality.

Cerebrospinal Fluid Proteins↗

PubMedDate not supplied

[Conditioning of affect-induced breath-holding spells].

Breath holding spells often arise in the context of affectively dramatic conflict situations between mother and child. Assessment by psychopathological screening instruments, however, has not given empirical evidence of an increased psychiatric morbidity in these children. Therefore, in our study we did not concentrate on basic psychopathology but on behavioral variables that might be effective during the ongoing attack episode and, hereby, exert an influence on the risk of chronification (relapse rate). The main goal of this approach is to examine secondary reinforcement effects on the attack behavior according to the learning principle of operant conditioning. Our sample consisted of 28 children and ten siblings as control group. To control for effects of behavioral disorders in the sample, we applied the Marburger Verhaltensliste (MVL) on the level of the child, and the Familienfragebogen (FFBO-III) on the level of family adaptation. The main assessment instrument, however, was the Functional Behavior Analysis (FBA) in order to measure the trigger, reaction and consequence conditions in the course of given attack episodes. MVL and FFBO-III results confirm the lack of basic psychopathology in the patients and their families. The individualized FBA's can be transformed in a taxonomy of five distinct types. All the first three types are triggered by intensive conflict situations and show a high relapse rate (type 1) if the mother reacts in a rewarding manner with positive consequences for the child (reinforcement condition), a dramatically reduced rate (type 2) if the mother reacts neutral (extinction condition), or a heterogeneous pattern (type 3) if the mother reacts punishing (punishment condition). In type 4 (pallid type) and type 5 (triggered spontaneously), respectively, no responsiveness to conditioning effects can be recognized. With respect to parent counselling, a recommendation for a quiet and consequent reaction can be concluded, especially in the case of a preceding conflict situation. The empirical results are integrated into a hypothetical model on pathogenesis that delineates the interaction of neurophysiological and behavioral factors in the maintenance of breath-holding spells.

Apnea↗

PubMedDate not supplied

[Mitochondrial diseases].

Mitochondrial disease are a heterogeneous group, combining multiple symptoms resulting from defects in various organs. Thus identification of a particular mitochondrial disease due to clinical symptoms is not possible. However, simple biochemical tests can provide guiding and reliable results quickly. We present a classification of the mitochondrial diseases, describing important clinical symptoms and explaining a diagnostic plan to identify defects of biochemical mitochondrial pathways.

Abnormalities, Multiple↗