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Biomedical subjects

F Hendrikse

Publications and source records attributed to F Hendrikse.

18 recordsLinked to original sources

[Future need of eye care for patients with diabetes mellitus, costs and effectiveness].

OBJECTIVE: To determine how much vision loss caused by diabetic retinopathy can be prevented in the Netherlands until 2020, and what resources will be needed to do so. DESIGN: Computer simulation study. METHODS: The population forecasts of the Dutch Central Bureau of Statistics constituted the starting points. The literature provided data on the disease progression and the effectiveness of screening and treatment. A new continuous computer simulation assessed one scenario without eye care and four scenarios with different screening frequencies. Effects were measured in sight gain, costs were based on official charges, benefits included savings on disability facilities and reductions in production losses. RESULTS: The number of diabetic patients was estimated to increase form 287,000 in 1993 to 406,000 in 2020. Compared with a setting without ophthalmic care, full compliance with official screening guidelines would reduce the prevalence of blindness in 2020 by 45% among type I patients, and by 20% among type II patients. Financial benefits would exceed costs for type I, but not for type II diabetes. While the intensity of eye care would rise, the number of eye examinations would increase approximately in the same proportion, but the number of laser treatments would increase at a much slower rate. 30% more ophthalmologists were estimated to be required in 2020. CONCLUSIONS: The sharp increase in the number of diabetic patients plus the proven effectiveness of photocoagulation will inevitably cause a major rise in the need for ophthalmic care.

Adult

[Role of the vitreous body in diabetic retinopathy].

UNLABELLED: In recent years it has become evident that the vitreous must play a role in various aspects of diabetic retinopathy. The exact role of the vitreous is however in many aspects still ill defined. There are structural changes of the vitreous, as for instance vitreous liquefaction and posterior vitreous detachment, that are associated with the occurrence and earlier onset of diabetic retinopathy. Further there are angiogenic and angioinhibitory factors in the vitreous which influence neovascularisation by means of endothelial cell proliferation. Photocoagulation of the retina can cause structural changes (posterior vitreal detachment) and histological changes (increased hyalocytes activity) which can protect against the progression of proliferative diabetic retinopathy. The role of vitrectomy in protecting against proliferative diabetic retinopathy is generally concerned to be related to the removal of the vitreal scaffold. But vitrectomy can also induce changes in the oxygenation of the eye. If complete detachment of the posterior vitreous can be achieved it might be possible to further slow the progression of diabetic retinopathy. CONCLUSIONS: It is possible that in the future manipulation of the vitreous by means of enzymes and lasers can play a role in the treatment and prevention of diabetic retinopathy.

Diabetic Retinopathy

[Consensus on diagnosis, screening and treatment of diabetic retinopathy].

The management and timing of the treatment of diabetic retinopathy has changed in recent years. Screening for diabetic retinopathy should preferably be performed by ophthalmologists. However, in concert with the local ophthalmologist general physicians with knowledge and experience of eye investigations can play a certain part in the screening for diabetic retinopathy. Good communication between general physician and ophthalmologist is of special interest in detecting the risk factors; systemic hypertension, poor metabolic control, pregnancy, proteinuria and rapid metabolic control of previously high blood glucose levels. For the time being fundus photography as a screening method can only be used on a limited scale and under scientific conditions. No consensus could be reached concerning the pre-treatment use of fluorescein angiography.

Diabetic Retinopathy

Intraocular human thrombin infusion in diabetic vitrectomies.

The effectiveness of intravitreal thrombin infusion during vitrectomy was prospectively evaluated in eight diabetic patients with persistent vitreous hemorrhages and severe proliferative vitreoretinopathy. A concentration of 80 units/ml of human thrombin diluted in BSS-plus infusion fluid was used. Bleeding time ranged between 2 and 15 seconds (mean, 5 seconds). The reduction of bleeding facilitated surgery. In five of the eight cases the vitreous was clear one day postoperatively. One month postoperatively six eyes had clear media. No additional postoperative intraocular inflammation developed. These results suggest that human thrombin causes less inflammation than bovine thrombin.

Diabetic Retinopathy

A long-term follow-up study of laser coagulation of neovascular membranes in angioid streaks.

We treated 30 eyes (24 patients) with angioid streaks and neovascular membranes using light coagulation. Of 30 eyes, 16 showed either ameliorated or unchanged visual acuity. Twelve of the remaining 14 eyes retained a visual acuity of 20/200 or better. In 11 patients, the fellow untreated eye showed central macular degeneration with loss of central vision. The follow-up period ranged from two months to 16 years (mean, 3.4 years).

Adult

Retinal abnormalities in Alport's syndrome.

The ophthalmological findings in 13 patients with Alport's syndrome are reported. Special attention was given to the retina and retinal functions. Flecked retinopathy was present in 12 out of the 13 cases. Two cases showed tortuosity of the retinal vessels. Retinal function tests showed no significant abnormalities. This study suggests that in Alport's syndrome, retinal lesions are more common than has been reported until now.

Adolescent

Retinal function immediately after Nd.YAG-laser treatment.

The purpose of this study was to evaluate the effect of Nd.YAG-laser treatment on retinal function. All the patients treated showed a temporary decrease of visual acuity immediately after treatment. The ERG and EOG recordings were identical before and after treatment. The Umazume-Ohta test showed temporary central or paracentral relative field defects in all cases investigated.

Cataract Extraction

Iris angiography after cataract extraction and the effect of indomethacin eyedrops.

To test the efficacy of topical indomethacin eye drops in preventing cystoid macular edema (CME) postcataract extraction, iris fluorescein and fundus fluorescein angiography were performed in two series of eyes that underwent intracapsular cataract extraction; 25 control eyes and another 25 eyes receiving indomethacin eye drops. In the latter group, 1% indomethacin eye drops were given three times a day, from 1 day preoperatively to 4 weeks postoperatively. In these two groups, there was a statistically significant difference in the findings on iris fluorescein angiography in the early and late period. There appeared to be a correlation between the degree of dye leakage on iris fluorescein angiography and the occurrence of CME. Fundus examination showed 6-9 weeks postoperatively perifoveal vascular leakage in 28% of the control group and in 8% of the indomethacin group. The results show from this study support the theory that prostaglandin form an etiological factor of CME.

Aged