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Biomedical subjects

F Hennig

Publications and source records attributed to F Hennig.

11 recordsLinked to original sources
PubMed2004

Effect of acute brain death on release of atrium and B-type natriuretic peptides in an animal model.

INTRODUCTION: Atrium and B-type natriuretic peptides (ANP and BNP) and big endothelin (ET)-1 are markers for severity of heart failure and may be used in the quality assessment of donor hearts. Elevated cardiac troponins predict early graft failure after heart transplantation. This study evaluated the effects of acute brain death (BD) on the release of ANP, BNP, big ET-1, and cardiac troponins in an animal model. MATERIALS AND METHODS: Pigs were randomized into a BD group (n=5) and a control group (n=5). In the first group, acute BD was induced, and anesthesia was stopped. In the control animals, a sham operation was performed, and anesthesia was continued. Parameters were measured at baseline and for 13 hours postoperatively. RESULTS: After acute BD, there were significant hemodynamic changes. In the control group, the BNP level was higher than in the BD group and decreased over time (P =0.016). There was no significant change in BNP release in the BD group up to 13 hours (P =0.1). ANP release remained stable over time in the control group (P =0.35) but decreased in the BD group (P =0.043). The big ET-1 levels were not different between groups. Cardiac troponin I was elevated in the BD group 5 hours after BD (P< 0.05) but remained under 1.5 mg/L throughout the study. CONCLUSION: Acute BD did not lead to an increase of BNP and ANP levels. Moreover, intact brain function seems to augment the release of natriuretic peptides from the myocardium. Further clinical evaluation of prognostic values of natriuretic peptides for the assessment of donor hearts is necessary. Cardiac troponins are a useful additional tool in the evaluation of donor hearts.

Acute Disease↗
PubMed2000

[Traumatic sternoclavicular instability. A therapeutic alternative].

Traumatic instability of the sternoclavicular joint is a rare diagnosis. It is usually treated by different bandaging techniques without the possibility of early functional aftercare. In the period between 1 January 1996 and 31 December 1998, a total of eight patients with unstable sternoclavicular joints requiring surgical treatment were treated with Balser plates. The population comprised seven anterior and one posterior dislocations. The results achieved with this alternative treatment option, which offers the advantage of enabling early functional aftercare, are presented. Seven of eight patients were available for follow-up. The eighth patient moved from the area. The Constant Score ranged between 84 and 100 points (average 89 +/- 6.6).

Adolescent↗
PubMed1995

[Nonelastic deformations of polyethylene inlays in hemiprostheses].

In most models of hip prosthesis, the inlay is formed by a layer of polyethylene. The attrition of polyethylene results from two components, wear and nonelastic deformation. Former studies analysed total attrition. The aim of this trial was to measure solely the non elastic deformation. Nonelastic deformation was investigated using two different types of bipolar hemiprostheses to exclude influences of different shaped metal caps. The bipolar hemiprostheses were tested with a hydraulic pulser. 1 x 10(6) cycles of a halfsinewave with a stress of 4600 N at a frequency of 8 Hz were used. The whole procedure was carried out in isotonic saline solution. Stress was applied along a single axis to prevent any wear. After the test, the inner surface of the polyethylene inlay was analysed with a touchpeg. As the inlays had different inner diameters, the analysis of the surface was defined along radials of 5 degrees, 25 degrees and 45 degrees. The nonelastic deformation in the direction of the main stress at 45 degrees was higher than at the lateral areas. The nonelastic deformation measured was between 0.2 and 0.6 mm/a, i.e. 5 to 30% of total attrition. There was a significant difference between the two types of inlays. The model with several pegs and edges for a complicated snap mechanism had a significant higher nonelastic deformation (alpha = 0.05) than the smooth shaped inlay.

Biomechanical Phenomena↗
PubMed1992

[Surgical treatment of injuries of the lower cervical spine].

Fractures at the C3-C7 level present primarily diagnostic problems. If instability is certain, therapy is simple: using an image intensifier, dislocation is reduced under general anesthesia and relaxation, and later secured by anterior interbody fusion. Compound fractures demand total resection of the vertebral body and its (autologous) replacement. Plating of the adjacent segments is mandatory. Neurological function after a dysfunction free interval may be fully restored if primary reduction and stabilization are achieved. Postponed treatment is less useful, but may also improve neurological deficits.

Bone Transplantation↗
PubMed1991

[Indications for bipolar prosthesis in femoral neck fractures. A retrospective study of the prognosis in geriatric patients with bipolar prostheses with reference to the preoperative health status].

In Germany the decision to implant a bipolar prosthesis in patients with femoral neck fracture depends mainly on the patient's age and general condition. Taking into account the clinical results to date, however, these criteria alone appear not to be adequate. In our hospital 182 patients were provided with a bipolar prosthesis between January 1986 and February 1989 after traumatic hip fracture. By June 1990, the end of this investigation, 56% had died. In a retrospective study of the 67 surviving patients 25 (6-48) months postoperatively, we found that the results obtained with this bipolar prosthesis were comparable to those seen with total hip endoprostheses according to the Harris hip function score and to radiological findings regarding the frequency of loose stems and protrusion. We also employed a standardized system to evaluate the clinical condition of each patient preoperatively as well as the intra- and postoperative complications. These clinical data were compared with the postoperative survival and the Harris hip score. We found: (1) Good to excellent results in 45% (greater than 80 points), satisfactory results in 52% (51-80 points) and poor results in 3% after a period of up to 48 months. Good to excellent functional results were frequently obtained in healthy older patients. (2) Life expectancy in our group of 182 patients was shorter than in the normal population of the same age. (3) The reduced life expectancy was not attributable to the fracture trauma or the operation but rather to preexisting unrelated causes. In fact the fracture trauma itself often appeared to be a result of the patient's preexisting bad health.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1988

[Bundle nailing--an evaluation after 27 years].

The development of modern osteosynthetic procedures has made the use of bundle nailing uncommon. Bundle nailing is restricted to extraordinary situations, but when indication is correct, it is superior to alternative procedures. From a current viewpoint only two indications remain: one are the fractures of the humeral shaft which cannot be treated conservatively, and the second are fractures of the femur in children if serious complications endanger conservative treatment. Simple instruments and implants as well as simple technique produce excellent results in the hands of experienced surgeons even if seldom performed. The rate of relevant complications for the above mentioned indications was 0.91% in a total of 560 bundle nailings; those were complications which either led to reoperation or negative effects on function.

Adult↗
PubMed1986

[Supracondylar upper arm fracture in childhood].

For the last 28 years condylar upper arm fractures have been treated at the Department of Surgery of Erlangen University mainly via the extention after Baumann. 182 cases out of 306 were followed up clinically. Extension treatment after Baumann is a technically simple procedure and offers the possibility of continual control and correction of repositioning. Treatment results are good. We could not observe Volkmann's contraction among our patients. Operation does not decisively improve the results, whereas the risk is increased. It should remain restricted to those cases only which cannot be successfully treated by conservative measures.

Casts, Surgical↗
PubMed1977

[Investigation of pregnancy hypertension as a consequence of utero-placentar ischemia (author's transl)].

An attempt at provoking gestosis by constricting the uterine artery was made using pregnant rats and rabbits. The experiment failed. Reducing the circulation by means of Z-sutures in the region of the nidation site failed to produce symptoms of gestosis also. The result of the uterine manipulations was abortion and intra-uterine retardation of the product of conception. Though it was not possible to verify the pathogenesis of gestosis due to impaired circulation of the uterus. On the basis of these experiments previous gestosis hypotheses stemming from animal experiments cannot be questioned. However, it is though-provoking that a review of the literature reveals that the results of these "classical model experiments" cannot always be interpreted uniformly.

Animals↗
PubMedDate not supplied

Quantitative determination of chromium and nickel in tumour and tumour-free human tissue.

Environmental pollution with carcinogenic substances, in addition to individual abuse, are discussed as important factors causing development of cancer. We must assume that certain nickel and chromium compounds, which are ubiquitous in our ecosystem, must have carcinogenic effects on humans too. The aim of this study is therefore to examine the extent to which the accumulation of the potentially carcinogenic metal ions nickel and chromium could be measured in tissue from tumour patients. We examined tumour and tumour-free tissue obtained from a total of 48 patients who had carcinomas of the stomach, bowel, or kidney. We also analyzed nickel and chromium content in whole blood and urine samples from these persons. The quantitative metal estimations were done using atomic absorption spectrophotometry. Differences between chromium and/or nickel content in tumour or tumour-free tissue were not observed. An accumulation of these metal ions in tumour tissue is therefore improbable. We were also unable to find differences in metal content with regard to chromium and nickel as related to the appearance of tumour in the organ. In contrast, tumour patients had a 5- to 7-fold increase over normal values for chromium and nickel in blood and urine. This was attributable to unavoidable contamination of tissue and body fluids with chromium- and nickel-containing instruments during major surgical procedures.

Adult↗