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Biomedical subjects

F Henry

Publications and source records attributed to F Henry.

At least 19 recordsLinked to original sources
PubMed1998

Ageing and rheological properties of facial skin in women.

Ageing affects the mechanical properties of skin. Studies using objective measurements on facial skin have been rare and yielded contradictory information. In the present study, the age-related changes occurring in the mechanical properties of facial skin were reviewed using a computerized suction method. A total of 200 healthy women, aged from 17 to 68 years, were enrolled. Data show a significant increase in skin extensibility and a significant decline in elasticity with ageing. These changes become obvious in women approaching 40 years.

Adolescent↗
PubMed1998

[Skin microcirculation, adherence molecules and inflammatory dermatoses].

Skin is a peculiar organ with regard to its microcirculation. The dermal vasculature is enriched with abundant anastomoses. It forms a single compartment where blood can be pulsed in any direction without always following an arteriolovenular gradient. Under various pro-inflammatory stimuli, endothelial cells express diverse adhesion molecules whose specificity leads to the intradermal collection of specific leukocytic lineages. Such basic mechanism is at the origin of all inflammatory dermatoses. It is possible and even probable that some antihistamines, flavonoids and antiseptics modulate in a beneficial way the expression of some adhesion molecules.

Anti-Infective Agents, Local↗
PubMed1998

[Current classification of panniculitis].

The inflammatory diseases of the hypodermis represent a difficult problem both for the accurate diagnosis and treatment. Several distinct etiologies and pathomechanisms can be responsible for such lesions. We present an updated panniculitis classification.

Humans↗
PubMed1997

Sodium hypochlorite, bleaching agents, and the stratum corneum.

Interactions between bleaching agents containing sodium hypochlorite (NaOCl) and human stratum corneum are complex and not fully understood. The same applies when NaOCl is used as a war gas decontaminant. In this study data yielded by in vivo testing and an ex vivo bioassay are compared. Fifteen volunteers received patch tests of a neat proprietary NaOCl bleaching agent for 15, 30, 45, 60, and 90 min. No clinical reaction was seen. Reflectance colorimetry, transepidermal water loss (TEWL), and capacitance were measured for 72 hr after patch removal. Squamometry was also performed using D-Squames and colorimetry of the samples. In addition, the ex vivo corneoxenometry bioassay was conducted on various dilutions of the bleach. Data reveal that conductance and squamometry were more sensitive than TEWL to disclose the action of bleach upon the stratum corneum. Corneoxenometry proved to be a good predictive ex vivo bioassay, indicating the same information as the in vivo tests. Both squamometry and corneoxenometry appear valuable and complementary in assessing infraclinical damages of human skin by a NaOCl bleaching agent.

Adult↗
PubMed1997

Striae distensae of pregnancy. An in vivo biomechanical evaluation.

BACKGROUND AND OBJECTIVE: Striae distensae of pregnancy is a common finding. There is currently a lack of information about the rheological characteristics of such lesions. The purpose of this study was to compare the mechanical properties of striae distensae before and after delivery. PATIENTS AND METHODS: A total of 79 primigravid entered the study. Rheological properties of skin were evaluated in vivo using a Cutometer equipped with a 2-mm probe. RESULTS: Mechanical properties of striae distensae developing during pregnancy resembled those of the surrounding skin. By contrast, significant differences were yielded during post-partum. Extensibility of striae distensae was increased although parameters of elasticity remained normal. CONCLUSIONS: Rheological properties of striae distensae of pregnancy vary in time. This might reflect the changes in hormones and in the mechanical stresses normally setting the skin under tension.

Adult↗
PubMed1997

Age-related changes in facial skin contours and rheology.

OBJECTIVES: To evaluate the age effect on both the mechanical properties and wrinkling of facial skin. This topic has not previously been addressed in the literature. DESIGN: A total of 180 white women aged 18 to 67 years participated in the study. Each of the 5 decades of age was represented by 30 subjects, with the exception of menopausal women aged 48 to 57 years who were allocated to two groups of 30 according to the use or non-use of hormone replacement therapy (HRT). SETTING: A University medical center, Belgian SSTC Research Unit 5596. MEASUREMENTS: Mechanical properties of the skin were measured on the face using a computerized suction device. Skin contours were assessed using optical profilometry and computerized image analysis. RESULTS: Skin aging of the face is characterized by a progressive increase in extensibility associated with a decreased elasticity. The loss of tonicity is accompanied by a progressive deepening of facial creases. HRT appears to limit the age-related rheological changes without showing a preventive effect on wrinkling of facial skin. CONCLUSION: Aging of facial skin resembles, in some ways, the features previously reported on sun-protected areas of the forearms. HRT has a beneficial effect that may slow the overall process of aging without, however, limiting the number and depth of wrinkles.

Adolescent↗
PubMed1997

Regional differences in stratum corneum reactivity to surfactants. Quantitative assessment using the corneosurfametry bioassay.

The skin does not react similarly to the presence of xenobiotics over all anatomic sites. Distinct regional differences have been described for irritancy and percutaneous absorption. The present study assesses the regional variation of stratum corneum reactivity to surfactants using the corneosurfametry bioassay. Stratum corneum was harvested from 6 body sites in 20 young adults. Corneosurfametry was performed using water, 1% SLS and a 5% soap solution. Data show that the best variable to assess regional variability in irritancy is the overall difference in corneosurfametry (ODC), comparing the effect of a given surfactant with water. The dorsal hand and volar forearm were the least reactive, the neck, forehead, back and dorsal foot the most reactive, sites. It is concluded that the corneosurfametry bioassay, through the ODC variable, is a practically noninvasive tool for the evaluation of regional variation in irritancy at the level of the stratum corneum.

Adult↗
PubMed1997

Topical retinol and the stratum corneum response to an environmental threat.

The functional consequences of using topical retinol on skin have not been thoroughly studied so far. The aim of this open study was to compare two preparations containing either retinol or vitamin E, using biometric evaluations. Three methods, namely the sodium lauryl sulfate (SLS) corneosurfametry bioassay, the ultraviolet (UV) squamometry test and optical profilometry of the UV-induced wrinkling process, were used to assess some properties of the stratum corneum. The retinol preparation achieved better scores than the vitamin-E cream in all three tests and appears to improve the resistance of the stratum corneum against some chemical (SLS) and physical (UV) threats. It also limits UV-induced shallow wrinkling.

Administration, Topical↗
PubMed1997

Collision of primary malignant neoplasms on the skin: the connection between malignant melanoma and basal cell carcinoma.

Several studies have reported the association of cutaneous malignant melanomas (MM) with carcinomas. Collision malignancies cases from our files were retrieved. Among a series of 78,000 primary cutaneous cancers, 11 were collision tumors of MM with basal cell carcinoma and 106 were basosquamous carcinomas while no association was found between MM and squamous cell carcinomas. It is concluded that coexisting and confluent malignancies of the skin might not always be a random event.

Adult↗
PubMed1996

Comparative effect of short-term topical tretinoin and glycolic acid on mechanical properties of photodamaged facial skin in HRT-treated menopausal women.

BACKGROUND AND OBJECTIVES: Cutaneous intrinsic ageing has been shown to be improved by hormone replacement therapy (HRT). Photoageing is, however, unresponsive to such treatment. The present double-blind study was undertaken to compare the beneficial effect of a 1-month topical treatment with 0.05% all-trans-retinoic acid or 6% glycolic acid. METHOD: Biomechanical properties were measured on facial skin of HRT-treated menopausal women using both topical products on the hemifaces for 1 month. RESULTS: Skin elasticity proved to be significantly higher at the tretinoin-treated site than at the glycolic acid-treated site. CONCLUSION: Objective non-invasive measurements of the biomechanical properties of facial skin show the superiority of retinoic acid over glycolic acid in improving a deleterious effect of ageing.

Administration, Topical↗
PubMed1996

Computerized evaluation of skin stiffening in scleroderma.

Modern non-invasive biometrological methods have proven to be helpful in monitoring some skin disorders. The present study was designed to evaluate the mechanical properties of skin in systemic scleroderma. The Cutometer SM 474 was used to measure the rheological properties of the skin in 33 patients suffering from scleroderma. The most prominent abnormality consisted in a marked reduction in skin extensibility. Changes occurring in time objectivate the evolution of the disease. Measuring the mechanical properties of skin in patients with scleroderma may be useful in monitoring the disease and its treatment.

Adult↗
PubMed1996

Mechanical properties of skin and liposuction.

BACKGROUND: Liposuction removes fat, setting the skin under tension, and could therefore alter the overall viscoelastic properties of the teguments. OBJECTIVE: To measure in vivo the mechanical properties of skin at the site of liposuction and to compare the viscoelastic values with those of the inner aspect of the forearms. METHODS: The Cutometer SEM 474 equipped with a 8-mm probe was used. RESULTS: Data show that cutaneous laxity, which is characteristic for an aging aspect, is not higher at the liposuction sites than on the reference area. CONCLUSION: Liposuction does not increase the clinical aspects of skin aging.

Adult↗
PubMed1996

Mechanical properties of the diabetic waxy skin.

BACKGROUND: In some diabetic patients, the skin of the hands has a waxy appearance. OBJECTIVE: To study subclinical skin stiffening in diabetic patients using a noninvasive, in vivo suction device measuring skin extensibility and elasticity. Skin thickness was also measured by high-resolution ultrasonography. METHODS: Evaluations were made on the dorsum of the hands and on the volar aspect of the forearms. RESULTS: In type 1 diabetic patients, the extensibility of skin was decreased while values of thickness and elasticity were increased. These alterations were most prominent on the hands. Similar modifications, although less pronounced, were also found in type 2 diabetic subjects. CONCLUSION: The reported biomechanical changes indicate the presence of subclinical skin stiffening in many patients with diabetes mellitus. Such noninvasive biometrological evaluations could be used for monitoring, rating and correlating some diabetes-associated disorders.

Adolescent↗
PubMed1996

Mechanical properties of skin in recombinant human growth factor abusers among adult bodybuilders.

A Cutometer was used to measure the mechanical properties of skin in 8 adult bodybuilders who were recombinant human growth hormone (hGH) abusers. Although skin deformability and biological elasticity remained within the normal range, an increase in dermal viscosity was noted. The expression of the activity of hGH or insulin-like growth factor I on target dermal cells is likely to be responsible for these findings.

Adult↗
PubMed1996

[Retinoids].

Explore the source record for details and available documents.

Aging↗
PubMed1995

Sleep EEG and developmental dysphasia: lack of a consistent relationship with paroxysmal EEG activity during sleep.

In order to clarify the relationship between developmental dysphasia and EEG abnormalities, paroxysmal activities during sleep were studied in a series of 24 children with expressive developmental dysphasia (mean age 8 years) and compared to a control group of 39 children (mean age 9 years). The children of both groups were selected excluding cases with prior history of neurological disease or epilepsy. In the control group, 37 children had normal sleep EEG while 2 children had paroxysmal abnormalities. In the dysphasic group, epileptic abnormalities were observed in 9 cases, rare in 4 cases and frequent in 5 cases (density: 2.5 to 66.2% of total sleep time). Nevertheless, paroxysmal abnormalities did not reach the frequency described in the Landau-Kleffner syndrome, and it is unlikely that EEG abnormalities could have produced dysphasia.

Aphasia↗