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Biomedical subjects

F Heppner

Publications and source records attributed to F Heppner.

65 records · Page 4Linked to original sources

New technologies to combat malignant tumours of the brain.

1. The primary problem in an effective treatment of a glioblastoma is the prevention of a recurrence. 2. For that purpose were the following therapeutical procedures undertaken: (a) Temporary implantation of radio cobalt in the brain itself (1957): (b) Clostridium butyricum M 55 was used to render the centre of the tumour fluid (1967): (c) Podophyllin was used to destroy the border of the tumour (1980); (d) The CO2 Laser beam (1975); (e) The electromagnetic heat induction deep in the brain (1973-1978). 3. In order to make the operation and postoperative phase safer for the patient, the following precautions were drawn upon or employed: (a) Hyperbaric oxygenisation in the pressure chamber (1971); (b) The anti-G-suit (1974); (c) the computer controlled automatic infusion pump (1980), and (d) the telemetric measurement of intra-cranial pressure (1975). 4. Apart from the pressure chamber, the mentioned devices were all supervised and developed in the department of the author. 5. The first successful means in the prevention of the recurrence of a glioblastoma multiform seems to be the telethermic method mentioned in 2 (e) above.

Animals

Variations of pial arteriolar diameter, arterial blood pressure and arterial blood density in the cat.

Feline pial arteriolar diameters (CVD, cerebral vessel diameter), mean arterial blood pressure and blood density were recorded continuously in order to examine the relation between rhythmic diameter variations and oscillations of blood pressure and density. Under constant arterial pressure, blood density and CVD oscillations of 2-6/min were recorded using a photometric technique. Furthermore, pressure and density variations were induced by bleeding and reinfusion of blood, to observe their influence on CVD. The latter over a period of time become synchronized to parallel variations of pressure and density during hemorrhagic hypotension. This observance was noted after an initial lag phase.

Animals