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Biomedical subjects

F Herman

Publications and source records attributed to F Herman.

At least 37 records · Page 2Linked to original sources
PubMed1986

A high melting cis-[Pt(NH3)2[d(GpG)]]adduct of a decanucleotide duplex.

The [cis-Pt(NH3)2(d(GCCGGATCGC)-N7(4), N7(5))]-d(GCGATCCGGC) duplex has been prepared with Tm = 49 degrees C (vs 58 degrees C for the unplatinated form). NMR of the ten observable imino protons supports a kinked structure with intact base pairing of the duplex on the 3'-side of the d(GpG).cis-Pt chelate (relative to the platinated strand) The modification of the B-DNA type CD spectrum, due to the platinum chelate, is comparable to that observed for the platination (at a 0.05 Pt:base ratio) of the Micrococcus Lysodeikticus DNA (72% GC).

Base Sequence↗
PubMed1980

The tetraphocomelia-cleft palate syndrome in identical twins.

An identical pair of twins with the tetraphocomelia-cleft palate syndrome is presented. It is hypothesized that Roberts' syndrome and the pseudothalidomide syndrome, previously reported as separate entities, represent different manifestations of the same autosomal, recessively inherited malformation pattern.

Abnormalities, Multiple↗