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F Hess

Publications and source records attributed to F Hess.

At least 73 records · Page 4Linked to original sources
PubMed1978

[Generic symptoms of Hodgkin's disease in relation to other prognostic criteries (author's transl)].

In 1967-1973, 74 patients with histologic classified Hodgkin's disease were treated in Marburg. We proved the incidence of the most important prognostic criteries: stage, histologic type and clinical symptoms. These criteries are evaluated as equally significant and independent. The B-symptoms, fever, weight loss and night sweats we found in 24 patients, 18 (75%) of them were in stage IV. In the remaining 6 patients in stage II and III, the B-symptoms were followed by relapse or generalisation. We think that the good correlation to the stage means, that clinical symptoms as prognostic signs are not independent.

Body Weight↗
PubMed1977

[Combination chemotherapy in patients with disseminated bronchogenic carcinoma (author's transl)].

49 patients with disseminated bronchogenic carcinoma (small cell, 16;squamous cell, 17;large cell, 12;adeno, 4) were treated with a combination of adriamycin, cyclophosphamide, vincristine and DTIC. In a randomized series (21 patients) chemotherapy alone was compared to chemotherapy plus heparin. Partial remission was achieved in 8 patients with small cell carcinoma, in 5 patients with large carcinoma and in 2 patients with squamous cell carcinoma. The survival of patients who responded to therapy was greater than the survival of patients who did not respond to therapy. The duration of remission and the survival time was not longer in patients who had additional heparin therapy.

Antineoplastic Agents↗
PubMed1977

Auxiliary liver transplantation in the rat, influence of the condition of the recipient's liver on the fate of the graft.

To evaluate the influence of the functional state of the recipient's liver on the fate of an auxiliary liver graft in rats, diverse surgical interventions were carried out on the recipient's liver following transplantation of an auxiliary liver. All grafts consisted of 30% of the liver mass, were supplied with portal blood only, and provided with bile drainage. Permanent graft hypertrophy was observed when the recipient's liver was resected subtotally, in addition to the ligation of the bile duct. Ligation of the bile duct performed separately has a more pronounced effect on the increase of the weight of the graft than subtotal hepotectomy. If only portal blood was deviated to the graft, grafts atrophied. It is concluded that the functional efficiency and condition of the graft vary directly with the degree of functional impairment of the recipient's liver, compair functional hypertrophy. The present results do not seem to indicate the presence of a specific hepatotrophic factor in portal blood.

Animals↗
PubMed1976

[Results of radiotherapy of bronchial carcinoma (author's transl)].

In a joint retrospective study by 17 radiotherapy clinics in German-speaking countries the results of treatment of bronchial carcinoma after radiotherapy were analysed in 7503 cases. The age peak was between the 60th and 70th year. Squamous-cell carcinoma was the most frequent histological type, followed by anaplastic carcinoma, with adenocarcinoma being rare. There was a high proportion of histologically not clearly identified cases (27% in central and 35% in peripheral carcinomas). Survival rate at one year was 31% for central (3662 patients) and peripheral (961 patients) tumours, but only 2% at five years. Prognostically there was no difference between histological types and kind of radiotherapy or technique, but total dose affected survival rate. At a total dose of less than 5000 rd the survival rate at five years was minimal. The prognosis of combined surgical and radiotherapeutic measures was slightly better than with a radiotherapy alone, but results were unpredictable for the individual case. It is concluded that radiotherapy aiming at cure should be used in imoperable bronchial carcinoma if the tumour state and general condition of the patient appear to make a cure possible. But if this is not the case, radiotherapy should be used only palliatively, i.e. only to ameliorate symptoms.

Adenocarcinoma↗
PubMed1976

Azathioprine hepatotoxicity, direct complication or secondary effect in rat liver transplantation.

The risk of azathioprine-induced hepatocellular damage was investigated using the auxiliary liver transplantation model in rats. This model permits to study the effect of the drug on both graft and the recipient's liver vascularized in different ways. Neither histopathological changes were observed, nor could any deaths be directly attributed to toxic effects of the drug on hepatocytes. Morphological lesions were absent in treated and untreated, subtotally hepatectomized rats with normal bile flow. However, lesions did become manifest after reimplantation (grafts) and/or ligation of the common bile duct (hosts). We concluded that in rats azathioprine is toxic for hepatocytes only when the normal bile flow is impeded, independent of the way of the liver vascularization.

Animals↗
PubMed1976

[Electron microscopy studies on the pinocytosis activity of Ehrlich ascites tumor cells in monolayer culture].

During the phase of exponential growth ferritin was added to the culture medium of monolayer cell cultures from the Ehrlich ascites tumor in order to observe the pinocytosis phenomenon in these cells by means of electron microscopy. After a phase of adsorption, the ferritin arrived in vesicles and vacuoles of the cytoplasm - probably by ligature of coat invaginations. Within larger-sized vesicles, which might have been formed by fusion of smaller ones, less electron-dense ferritin-free internal compartments are resulting possibly from interaction with primary lysosomes; this is interpreted as a sign of interior digestive phenomena. Sometimes, this internal compartment was coated with a structure similar to a membrane. In the further course, concentration of the electron-dense zones containing ferritin occurred in the marginal zone of the vacuoles. Some vacuoles comprised two or three of the less electron-dense compartments. Vacuoles containing ferritin were also observed comprising residual membranes. The formation of these transition stages to residual bodies is regarded as an interaction and fusion of heterophagocytic or autophagocytic vacuoles with primary lysosomes.

Animals↗
PubMed1975

Studies on the oxygen supply of heterotopic auxiliary liver grafts in rats.

Heterotopic auxiliary liver transplantations were performed in rats using the method of Hess et. al. [6]. Oxygen pressure of liver tissue was measured with a Pt-surface electrode of Kessler and Lübbers [10]. After ligation of the hepatic artery, liver tissue PO2 decreased and remained low during further preparation. Only two of the seven lobes of the rat liver (= 30% of the parenchyma) were used as a graft. After revascularization and application of a gelatine plasma substitute, tissue PO2 of the graft increased to values of normal rat liver, although the graft was supplied with portal blood only. We suggest that one reason for this is the increase of portal perfusion rate, for the whole amount of portal blood perfuses only 30% of liver parenchyma. In the first month after transplantation PO2 of the graft parenchyma was low, but increased continually in the following months, reaching PO2 values of normal rat livers after 1 year.

Animals↗