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Biomedical subjects

F Heydolph

Publications and source records attributed to F Heydolph.

15 recordsLinked to original sources
PubMed1991

Serum prolactin concentration and hypothalamic-pituitary hormone release in CF-children.

Some experimental data from animals suggest that prolactin (PROL) is involved in sweat production and modulates the chloride concentration of sweat. We determined the serum PROL level by RIA in 38 CF-patients (age: 3-24 years) and 48 patients with bronchial asthma (age: 2-18 years) and found no concentration differences between the two groups each taken as a whole; the TSH level was increased in CF (p less than 0.05). Separate analysis showed a significantly higher PROL level in CF-females and in CF-children (male and female) under 12 years old (p less than 0.05). To assess the hypothalamic-pituitary system we performed the metoclopramide test (by Cerucal) on 30 children suffering from CF (n = 10), bronchial asthma (n = 10) or pyelonephritis (n = 10) for PROL, LH, FSH, TSH and HGH. The hormone release was normal for all kinds checked in all groups of patients. Hence it follows that the neurohormonal system of prolactin is normal in CF-patients and the increased serum PROL and TSH concentrations in CF should be seen as a regulatory phenomenon but not as a mechanism associated with the basic defect of the CF-disease.

Adolescent↗
PubMed1991

The eosinophilic granulocyte count in the respiratory secretions of children with chronic nonspecific respiratory diseases.

We performed cytologic evaluations of 6116 nasal and/or bronchial smears from 4510 patients (average age: 7.6 years; 3 months--17 years) suffering from different kinds of chronic nonspecific respiratory diseases (CNSRD); in 137 children (average age: 4.8 years) undergoing bronchologic examinations under general anesthesia we compared the findings with those for bronchoalveolar lavage (BAL). Nasal smears of 77 healthy children at a day care center (control group) were analysed four times per year for "significant secretory eosinophilia" (SEE; i.e. more than 13% eosinophils). We found: 1. Healthy children do not have such "SSE" in contrast to children with CNSRD who show different frequencies of "SSE" depending on the age of the child and the specific kind (diagnosis) of CNSRD. 2. 4.6% of infants (first year of life) were found to have SSE with a statistically significant correlation to increase in the following 10 years up to 50% of all children (p less than 0.001). 3. We found SSE in 4.41% of cases with relapsing bronchitis, in 7.14% (8.3% resp.) with chronic bronchitis, in 6.49% (9.2% resp.) with relapsing or chronic obstructive bronchitis and in 46.05% (55.3% resp.) with bronchial asthma (p less than 0.001). 4. The intensity of obstructive symptoms (nose: rhinitis; bronchus: dyspnoea) did not correlate with the number of eosinophils in the secretions. 5. Only the smear cytograms (nose/bronchus) enabled us to detect "SSE" whereas BAL cytograms were too insensitive (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1990

[BCG osteomyelitis and arthritis].

Since 1980 an increase of the frequency of osteomyelitis after BCG vaccination has been described by some european countries. In the GDR osseous impairments as BCG complication are rarely. The authors report on an 18 months old boy with lesions of the distal tibia and the ankle-joint. He was vaccinated with BCG in the neonatal period. In contrast to the local findings general symptoms were unimportant. The surgical treatment was completed by antituberculotic chemotherapy. This treatment was successful.

Ankle Joint↗
PubMed1990

[High-grade tracheomalacia and tracheal stenosis in congenital esophageal atresia with lower esophagotracheal fistula (Type III b)].

Stenosis and malacia of the trachea wall can provoke chronic stridor and/or chronic bronchitis, but usually stenosis and malacia only exist separately. The finding of an infant born with atresia of the oesophagus and a lower tracheoesophageal fistula which was cured by surgery on the 1st day of life are discussed. During the following 8 months we observed persistent stridor, chronic cough and (4-times) relapsing episodes of respiratory insufficiency ("nearly-sudden-infant-death-syndrome"/NSIDS) due to gastrooesophageal reflux (GER with aspiration) and severe tracheomalacia combined with tracheostenosis and bacterial infections (Pseudomonas aeruginosa). The strategy of therapy for GER and for the tracheal abnormality are discussed.

Esophageal Atresia↗
PubMed1990

[A contribution to the frequency and assessment possibilities of chronic aspecific respiratory tract diseases (CARD)--an epidemiological study in the mostly agricultural district of Neubrandenburg].

A test was carried out in order to determine representative information on CNSRD prevalence in children at the age of 3 to 15 and to check possibilities of registration. A clinical examination was performed at a totality of 122,400 children of a district, a sample test of 2,927 children was carried out. 10% of the children suffer from chronic diseases of the respiratory tract. In 3 to 4% of these children it is required to apply an acute or frequent therapy. The incidence of asthma bronchiale totals 1 to 2%.

Adolescent↗
PubMed1990

The pediatric bronchopneumonologic consultation centres (dispensaries) for children and adolescents suffering from chronic nonspecific respiratory diseases (CNSRD) in the G.D.R.

A survey is given of the three-level health service for young patient with chronic nonspecific respiratory diseases (CNSRD) in the GDR. The expected prevalence of the diseases in the young population (0-18 years) is 2-3% and still higher in regions with heavy air pollution. The pediatric working group of bronchopneumonology (in the Pediatric Society of the GDR) has organized a country-wide system of pediatric bronchopneumonologic consultation centres in the form of district (2nd level) and county dispensaries (3rd level) helping the local primary care pediatricians and general practitioners (1st level) in diagnostics, therapy and surveillance of such patients. The bronchopneumonologic county centres with all modern diagnostic and therapeutic facilities have a capacity which is sufficient for our country. However the function of the primary care doctors (to spot such children and refer them to the dispensaries), that of the district dispensaries (so far only 50-65% of expected patients in control!), and the availability of lung function test equipment and special bronchoscopic aids for infants and small children (in the county centres) needs to be improved.

Adolescent↗
PubMed1989

[Primary bronchial tumor in childhood--a case report].

Primary bronchial tumors are a rarity in childhood. According to the WHO-classification of 1981 Bronchial Carcinoid tumors and Mucoepidermoid carcinoms are listed as the most frequent histological types of the malignoma group and will be not longer associated with attributed benign tumors. In the literature especially the prognostic important early diagnosis and the difficulty of histological differentiation ist emphasized. In this paper is described a 12-year old girl suffering from a bronchial tumor. Throughout the 3 months of disease the diagnosis had been establisted by endoscopy. Surgically the resection of right middle and lower lobe was necessary. 7 years after bilobectomia the patient is without trouble of problems. The classification of the tumor ist problematic within the frame of in the WHO-classification and was discussed.

Carcinoma, Bronchogenic↗
PubMed1988

[Determinations of blood theophylline level in a severe asthma attack in childhood treated with respirator therapy].

The authors describe the course of a severe asthma emergency in a boy aged 13 years. Respirator therapy and bronchial lavage were required. A therapeutically effective serum concentration was initially obtained by an aminophyllin infusion (dose 1.2 mg/kg b.w./h after bolus injection with 6 mg/kg b.w.). In the further course of treatment the theophyllin concentration in serum decreased considerably. The advantage of theophyllin determination for guaranteeing a safe therapy is explained on the base of this case report.

Adolescent↗
PubMedDate not supplied

[Etiological, clinical and roentgenological aspects of mediastinal emphysema in children and adolescents].

The authors publish 8 cases of emphysema of the mediastinum in childhood and adolescence. The aetiologic variety and the radiologic symptoms are presented. Chronic diseases of the lungs and the respiratory tract, injuries of the thorax or iatrogenic genesis are the cause of emphysema. The spontaneous emphysema of the mediastinum is rare in childhood and adolescence.

Adolescent↗