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Biomedical subjects

F Higuchi

Publications and source records attributed to F Higuchi.

24 records · Page 2Linked to original sources
PubMed1987

[Concentrations of cefpiramide in bone and joint tissues].

A single intravenous dose of 2 g of cefpiramide (CPM) was administered prophylactically to 11 patients at 30, 60, 120, or 180 minutes before hip surgery. Peak concentrations in different tissues of CPM were observed in 30 minutes after intravenous injection. Mean concentrations of CPM were 246.0 micrograms/ml in peripheral blood, 298.5 micrograms/ml in bone marrow blood and 77.5 micrograms/g in cancellous bone at 30 minutes after administration. Half-lives of CPM were 152 minutes in peripheral blood and 105 minutes in bone marrow blood. The concentrations of CPM observed in the above study were higher and its retention longer than expected values.

Adult↗
PubMed1984

[A clinical and genetic study on the congenital dislocation of the hip].

Among 13,779 infants examined from 1974 to 1980 at Takashimadaira and Toride health centers, there were 45 patients with congenital hip dislocation, an incidence of 3.3 per 1,000 live births, that is, 0.08% and 0.53% respectively in male and female. The male to female ratio was 1: 7.4. Its incidence seems to be decreasing year by year with statistic significance, compared with the data previously reported. A family study was conducted based upon 117 patients with this disease diagnosed at the Tokyo Medical and Dental University from 1971 to 1980. Applying the recurrence rate of siblings and the incidence in the general population to the model proposed by Falconer, the heritability of liability to congenital hip dislocation in Japan is estimated to be 80 +/- 20% in males and 135 +/- 10% in females, which is beyond limitation of the heritability and much higher than Woolf's estimation (82% in male and 58% in female). This might be due to the insufficient size of the test population, but the genetic factors are presumed to play a more important role on the etiology of this abnormality.

Adult↗
PubMed1984

Genetic study on the congenital dislocation of the hip.

A clinical and epidemiological study on congenital dislocation of the hip (CDH) was attempted with a genetic analysis of this condition, and the following results were obtained. The frequency of CDH in the general population is 0.08% in males and 0.59% in females, the latter being clearly higher. In examining the changes in the frequency of CDH over the years using the data reported in the literature, a statistically significant tendency for the frequency to decrease in more recent years was noted. It was confirmed by the recurrence rate of the subsequent sibling and twin data that CDH is a multifactorial disease, and, in estimating its heritability, in males h2 = 0.94-1.01 and in females h2 = 1.38, which are markedly high estimates exceeding the limit of 1. This is perhaps attributable to the small number of patients in this series and to the differences in the characteristics between the data on the frequency of CDH in the general population and those of the present pedigree study. When the corrected value of the frequency in the general population was used in estimating the heritability, in males h2 = 0.54 approximately 0.74 and in females h2 = 0.68, which are almost identical to the American data.

Birth Order↗
PubMed1982

Bracing and supporting of the lumbar spine.

The orthopaedic surgeon should be familiar with various supports and braces for the treatment of low back pain. Severe cases of spinal instability always need a Hohmann overbridging brace, whereas the milder form of motion-segment instability is treated with one of the elastic supports. In cases of osteoporosis of the spine and insufficiency of the lumbosacral junction the Lindemann 2/3 semi-elastic brace is prescribed.

Back Pain↗