Biomedical subjects

F Hokoishi

Publications and source records attributed to F Hokoishi.

4 recordsLinked to original sources

PubMed1995

[Retroperitoneoscopic nephrectomy without pneumoperitoneum--experiments in pigs].

Laparoscopic nephrectomy has been performed widely for minimally invasive therapy. However, the procedure of insertion of needles and trocars can cause vascular and intestinal injuries. In addition, pneumoperitoneum using high pressure CO2 gas can cause circulatory and respiratory problems. In order to avoid these problems, we tried retroperitoneoscopic nephrectomy without CO2 gas in 8 kidneys of 4 pigs. A 1.5 cm skin incision was made just below the lowest rib and a small retroperitoneal space was made with the forefinger. The sheath of a 27 Fr rigid nephroscope was covered with a condom balloon and inserted into the retroperitoneal space. Under observing through the nephroscope, the condom was filled with 150-200 ml saline to make a space for the operation. After removing the nephroscope with condom, a scope and trocars were inserted into the space and retroperitoneoscopic nephrectomy was performed. Making the space with condom balloon in the retroperitoneal space was very efficient. The procedures succeeded in 8 and average procedure time was 3 hours. Retroperitoneoscopic nephrectomy without gas is a very attractive minimally invasive technique.

Animals↗

PubMed1994

[Bladder carcinoma producing granulocyte colony stimulating factor (G-CSF). A case report].

A 69-year-old woman was admitted to the hospital complaining of general fatigue and lower abdominal pain. She had undergone total cystectomy because of invasive recurrent bladder carcinoma three months ago. Histopathological diagnosis was transitional cell carcinoma (TCC) grade 3 and squamous cell carcinoma (SCC), pT3a. A goose egg-sized painful mass was noticed at the lower abdominal region. A CT scan revealed an intrapelvic fist-sized mass and suggested tumor recurrence with ileus caused by intestinal invasion. The laboratory examination showed remarkable leukocytosis of 79,700/mm3 in the peripheral blood and serum analysis revealed high value of granulocyte colony stimulating factor (G-CSF), 240 pg/ml (normal: less than 30 pg/ml). In spite of active treatment, the patient died of cachexia about a month after detection of the leukocytosis. The autopsy showed that the recurrent tumor had positive immunohistochemical staining for G-CSF, and the bone marrow had reactive proliferation mainly by granulocytes. From these findings, this case was diagnosed as bladder carcinoma producting G-CSF. G-CSF producting tumor of the bladder is very rare. This was the 8th case in Japanese literatures. The previous reports were reviewed and discussed.

Aged↗

PubMed1993

[Comparative assessment of the characteristics in various assay kits for prostate specific antigen].

Six kinds of assay kits based on different detecting principle for PSA were evaluated. Polyclonal antibody was used in 2 kits (Eiken, Markit-F) and monoclonal antibody in 4 kits (Ball Elsa, Delfia, Markit-M, Tandem-R). To evaluate their characteristics, sera of 12 female patients, 5 prostatectomized patients and 2 high stage prostate cancer patients were measured by these kits. On the female sera the polyclonal assay kits yielded values higher than the defined minimal sensitive value, but the kits of monoclonal antibody detected nothing. Dilution test of sera with high PSA level showed satisfactory results in every kit but the values of 6 assays were different to each other. For monitoring the recurrence or recrudescence of the prostatic cancer, the monoclonal antibody kits may be preferable to the polyclonal antibody kits. These results showed that we must understand the characteristics of every assay kit which is used clinically.

Adult↗

PubMed1993

[New microwave transurethral hyperthermia for benign prostatic hyperplasia--clinical evaluation].

Several types of hyperthermic apparatuses are employed to treat benign prostatic hyperplasia (BPH). As the prostate surrounds the urethra, we believed that transurethral heating allowed for more efficient and uniform heating. A new effective apparatus for this objective was developed. The size of our hyperthermic apparatus was about 52 x 45 x 20 centimeters and the originating frequency was 2,450 +/- 30 MHz. We used T-type thermocouples as temperature sensors. The transurethral applicator had a cooling system. Thirty patients complaining of obstructive symptoms due to BPH were treated. Hyperthermia was performed 3-6 times for each patients (two times per week). Each procedure was performed for 60 minutes. The temperature was controlled at 39 degrees C on the urethral surface (43 degrees C at prostate). The overall efficacy of this treatment was effective in 23 of the 30 patients (76.7%). In addition, there were no severe complications. As the size of this apparatus was miniaturized, it could be used at the bed side.

Aged↗