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Biomedical subjects

F Holle

Publications and source records attributed to F Holle.

At least 37 records · Page 2Linked to original sources
PubMed1976

[Non-resecting surgery for gastroduodenal ulcer. I. Pathophysiological principles (author's transl)].

Selective proximal vagotomy with pyloroplasty is a method which permits ulcers to be operated on with less morphological and pathophysiological disturbances than is possible with any other method. After ingestion, a reactive yet reduced acid secretion is still possible through the gastrin stimulus. The retained vagal antral release of gastrin seems to be without importance to the denervated delomorphous cells. Side effects of this type of vagotomy are small. The disturbances of motility and evacuation which also occur here can easily be corrected by an additional pyloroplasty suitable in shape and function.

Animals↗
PubMed1976

[Non-resecting surgery for gastroduodenal ulcer. II. Indication and technique (author's transl)].

The indication for the non-resecting combination method arises if the presence of genuine ulcer disease is confirmed by complete diagnostic measures (history, roentgenologic examination, endoscopy, secretion analysis and possibly psychic testing). An extended indication exists for erosive gastritis with hypersecretion, for hiatal hernia with reflux esophagitis (Berman's syndrome), for cardiospasm and prophylaxis of hemorrhage. The technique yields permanent curative results if a complete selective proximal vagotomy is combined with a pyloroplasty suitable in form and function. This is also true for duodenal ulcer. In 22% of cases of gastric ulcer, selective vagotomy with antrectomy is necessary.

Duodenal Ulcer↗
PubMed1976

[Non-resecting surgery for gastroduodenal ulcer. III. Clinical results (author's transl)].

During the last 12 years, 1489 vagotomies were performed at the Chirurgische Poliklinik of Munich University; 1339 of them were selective proximal vagotomies (SPV). The main indication was duodenal ulcer (n = 915) and gastric ulcer (n = 188), including emergency operations for extensive bleeding. Further indications were: sliding hiatal hernia, erosive gastritis and achalasia of the cardia. The SPA was combined in all cases with a pyloroplasty based on form and function. The results are shown in detail related to mortality (elective 0.5%), recurrency (1.6%) and functional results (good 88.2%, fair 7.2%, poor 4.6%). The combined operation of SPV with pyloroplasty is, in our opinion, an operative procedure which allows non resectioning surgical treatment of GDU without selection, i.e. based on form and function.

Acute Disease↗
PubMed1976

[Recurrent ulcer following vagotomy: completion of vagotomy or resection (author's transl)].

An adequate therapy must be directed towards the cause of the recurrent ulcer. This is incomplete vagotomy in most cases, more seldom a hypergastrinemia with stasis in the antrum after insufficient drainage, in hyperparathyroidism, in hyperplasia of the antral G cells or in gastrinoma. After confirmation of the diagnosis by endoscopy, a causal diagnosis must therefore be made which includes secretion analysis and determination of the gastrin profile (feeding test, glucagon provocation test, secretion or calcium infusion). Criteria for evaluation and clinical conclusiveness are shown in examples. The indication scheme, whether revagotomy alone, resection alone or the combination of the two corrective operations should be performed is determined according to these criteria. So far, 41 patients have been operated on with good results in accordance with this graduated indication.

Gastrectomy↗
PubMed1976

[Animal-experiment studies on the pathogenesis of peptic ulcer in the newborn].

Gastric secretion was studied in 188 fetuses of 28 pregnant dogs near term. Baseline secretory values were determined and gastric secretion was stimulated in additional fetuses with histamine, insulin, or gastrin. A significant increase in volume, acidity and pepsin output was observed in fetuses stimulated during the last week of gestation. Following maternal stimulation the placental transfer of histamine, insulin, and gastrin are demonstrated.

Animals↗
PubMed1976

[Combined anesthesia with propionylpromazine (Combelen) and methadone (Polamivet). A sure simple method of anesthesia in gastrointestinal surgery in dogs].

In more than 400 cases of gastrointestinal surgery on mongrel dogs, a combination anesthesia of a neuroplegic agent--propionyl promazine (Combelen) and methadone (Polamivet), an analgesic--was administered without additional intubation or ventilation. This type of anesthesia is simple to apply and practically without risk; the conditions for the operation are therefore excellent. No monitoring personnel is required, no intra- or post-operative incidents have occurred. Thus this method may be recommended as safe and simple for experimental abdominal surgery in dogs.

Anesthesia, Intravenous↗
PubMed1975

[Effect of selective proximal vagotomy with and without pyloroplasty upon basal and food stimulated serum immunoreactive gastrin in patients with duodenal ulcer. (author's transl)].

The effect of selective proximal vagotomy (SpV) with (12 cases) and without (5 cases) pyloroplasty upon basal and food stimulated serum immunoreactive gastrin (IRG) was studied in duodenal ulcer patients. Following SpV, fasting serum IRG increased in all subjects; the increase was more pronounced in subjects whose postoperative insulin tests were negative. Postoperatively, the mean integrated IRG output over 2 hrs in response to a meal was significantly higher than the preoperative mean value in the 17 patients. Pyloroplasty had no effect upon the IRG response following a test meal.

Duodenal Ulcer↗