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F Hui

Publications and source records attributed to F Hui.

44 records · Page 3Linked to original sources
PubMed1993

Biological consequences of overexpression of a transfected c-erbB-2 gene in immortalized human bronchial epithelial cells.

In order to examine the effects of the overexpression of c-erbB-2 (HER-2, neu) on human bronchial epithelial cells, a human c-erbB-2 expression vector was introduced into the simian virus 40 large T-antigen-immortalized human bronchial epithelial cell line BEAS-2B. Isolation of multiple clonal cell lines after selection revealed a wide range of expression of the gene product gp185erbB-2. While three of six clones tested expressed gp185erbB-2 at levels detectable by immunocytochemistry, only one, B2BE6, induced adenocarcinoma-like tumors in athymic nude mice. Both a nontumorigenic clone, B2BE2, and a tumorigenic clone, B2BE6, expressed comparable amounts of gp185erbB-2, which became phosphorylated on tyrosine in response to treatment with the c-erbB-2 ligands gp30 and p75. These data suggest that overexpression of c-erbB-2 in human bronchial epithelial cells can contribute to, but is not sufficient for, induction of tumorigenicity in this human model system.

Animals↗
PubMed1993

Interventional neuroradiology in the management of paediatric cerebral arteriovenous malformations: illustrative study of three case reports.

Cerebral arteriovenous malformations in children are unusual. Diagnosis and management of these lesions may present a problem. As the prognosis of this disease in children is worse than in adults, intervention is favoured over conservative therapy. Recently, interventional neuroradiology has emerged as an effective mode of treatment for these lesions, particularly in the subgroup of vein of Galen malformations where conservative and surgical therapies are associated with high mortality rates. Three representative cases are discussed to illustrate the role of interventional neuroradiology in different clinical situations. The first is a young child with a vein of Galen malformation. The second is a thirteen-year-old boy with an inoperable deep-seated arteriovenous malformation. The last is a twelve-year-old child with an occipital arteriovenous malformation. A multi-disciplinary approach to the management of these serious lesions is essential in order to achieve the maximum benefit with the lowest possible complication rate.

Adolescent↗
PubMed1992

Multiple cerebral arteriovenous shunts in children: report of 13 cases.

The authors present a series of 13 multiple arteriovenous malformations (MAVMs) in the pediatric population (16.9% of their overall series of brain AVMs in this group). Two types of MAVMs can be distinguished: congenital and acquired. Congenital MAVMs may be of the nidus or fistula type. They may be uni- or bilateral, placed in one or several cerebral lobes, separated or close one to another, or even systematized (Wiburn-Mason syndrome). The symptoms created by these MAVMs are the same as those encountered in the presence of other AVMs, with hemorrhage as revealing symptom in 31% of patients. The responsibility of one particular nidus in the onset of clinical signs is often difficult to determine. From an angioarchitectural point of view, it seems that venous drainage changes are mainly responsible for the symptomatology. The natural history of these MAVMs is difficult to assess; spontaneous regression has been noted in 15% of cases. Acquired cerebral MAVMs can be due to angiogenesis ("sprouting" or "non-sprouting") around a true AVM because of previous hemorrhage or ischemia, or to pial shunts associated with dural arteriovenous malformations. The treatment of MAVMs is difficult. Embolization seems to the authors the best therapeutic modality available, as surgery or radiosurgery are often unable to treat these multifocal lesions. Anatomical cure is rarely obtained; the therapeutic strategy has to be targeted on the symptomatic lesions.

Adolescent↗
PubMed1992

Computed tomography for oesophageal carcinoma: its value to the surgeon.

Between January 1988 and June 1991, 75 patients with carcinoma of the oesophagus or gastro-oesophageal junction were evaluated by computed tomography (CT). Fifty of these patients underwent operation, allowing 48 cases to have a detailed surgical and pathological verification of CT features. For thoracic oesophageal tumours the accuracy of CT was 59% for fat plane status, 86% for aortic contact, 81% for tracheobronchial tree compression and 66% for direct local invasion. CT was 69% accurate for identifying lymph nodes, of which only 38% contained metastatic deposits. For gastro-oesophageal junction tumours, CT was 74% accurate for fat plane status and 90% accurate for direct local invasion. Accuracy for detecting lymph node involvement was 63%, metastatic tumour being present in 91% of these nodes. By pathological staging, only 15% of all resections could be considered potentially curative. The value of CT was found to be in predicting a palliative or curative resection, and in warning the surgeon about possible infiltration of specific mediastinal or abdominal structures that would be encountered during operative dissection.

Adult↗
PubMed1970

Regeneration of the amputated amphibian limb: retardation by hemicholinium-3.

Doses of hemicholinium-3 which partially paralyze the larval salamander profoundly retarded regeneration of the amputated hind limb. The drug also reduced the vascularity and mitotic index of the regenerating tissue. After withdrawal of the drug the rate of regeneration returned to normal. Atropine, in a daily dose of 40 milligrams per kilogram of body weight, did not retard growth. These findings suggest that in the salamander acetylcholine may mediate neurotrophic activity.

Amputation Stumps↗
PubMedDate not supplied

Pseudoaneurysms within ruptured intracranial arteriovenous malformations: diagnosis and early endovascular management.

PURPOSE: To draw attention to pseudoaneurysms within ruptured arteriovenous malformations and to consider their diagnostic and therapeutic features, including pitfalls and precautions needed for safe embolization. METHODS: Radiologic and clinical charts of 189 patients who bled from intracranial arteriovenous malformations were retrospectively reviewed. RESULTS: Fifteen of the 189 (8%) were found to have pseudoaneurysms. Nine of the pseudoaneurysms were arterial, six were venous. In the early period following hemorrhage, nine patients were treated conservatively. The other six were treated with surgery (one case) or embolization (five cases) because urgent intervention was required. The clinical outcome for both conservative and interventional groups was generally favorable, but one patient in the conservative group died of a rebleed. In the patients who underwent embolization, the fragile nature of the pseudoaneurysm made it necessary to first embolize the artery feeding it. Embolization with particles was considered hazardous. Instead, free-flow (nonwedged) N-butyl-cyanoacrylate embolization proved safe and effective in treating both the pseudoaneurysms and arteriovenous malformations in these cases. CONCLUSIONS: This study highlights the importance of recognizing pseudoaneurysms in such patients and the importance of using free-flow liquid adhesive material on the artery feeding the pseudoaneurysm if embolization is required.

Adolescent↗