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F Hwang

Publications and source records attributed to F Hwang.

30 records · Page 2Linked to original sources
PubMed1983

The disordering effect of hyoscyamine drugs on phospholipid membranes.

The effect of hyoscyamine drugs on the fluidity of dipalmitoylphosphatidylcholine liposomes has been studied by differential scanning calorimetry (DSC), electron spin resonance spectroscopy (ESR), fluorescence polarization and freeze-fracture electron microscopic techniques. DSC results indicate that anisodamine, anisodine, atropine and scopolamine all increase the fluidity of dipalmitoylphosphatidylcholine liposomes but with different degrees of efficiency. The increasing of fluidity of dipalmitoylphosphatidylcholine liposomes by hyoscyamine drugs is in a dose-dependent way. Increase of the fluidity of phosphatidylcholine liposomes by anisodamine was also shown by the other three methods. The possible mechanism of hyoscyamine-membrane interaction is discussed.

Atropine↗
PubMed1975

Further studies on the effect of cyclic nucleotides on testis DNA synthesis.

The inhibitory effect of dibutyryl cyclic AMP (dbcAPM) on in vitro rat testis DNA synthesis appears to be relatively specific in nature. Of 7 organs studied, only testis and kidney in vitro DNA synthesis was significantly affected. In addition, another cyclic nucleotide, dibutyryl cyclic GMP (by dbc AMP), had no effect on in vitro testis DNA synthesis. This was true whether testis tissue was mature or immature. Similarly, by dbcAMP had no significant effect on in vitro testicular protein or RNA synthesis. The inhibition of in vitro testicular DNA synthesis by dbcAMP occurs while 3H-cAMP is accumulating in testis tissue. dbcGMP was found to have no antagonistic effect towards the inhibitory effect of dbcAMP on in vitro testis DNA synthesis.

Aging↗
PubMedDate not supplied

Binding of radioactivity from (14C)thiourea to rat lung protein.

Binding of radioactivity from [14C]thiourea (TU) to rat lung protein was found to occur in vitro. Two binding sites are present. One possesses low affinity/high capacity while the other is characterized by high affinity/low capacity. In vitro binding of [14C]TU to lung protein can be antagonized by the presence of either unlabeled congeners (alpha-napthylthiourea or phenylthiourea) or thiol-containing compounds (cysteine, reduced glutathione). Conversely, depletion of lung-reduced glutathione by means of diethyl maleate administration results in elevated protein binding. Prior administration (24 hr) of a sublethal dose of TU (which renders tolerance to a subsequent lethal dose in vivo) results in a decrease in in vitro binding of radioactivity from [14C)TU to lung protein. In addition, immature rats, which are less sensitive to the edematogenic effect of TU, bind less radioactivity from [14C]TU to lung protein when the drug is administered in vivo. These results suggest a correlation between [14C]TU binding to lung protein and the pathophysiological effect of the drug in the lung.

Aging↗