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Biomedical subjects

F I Mukhutdinova

Publications and source records attributed to F I Mukhutdinova.

At least 19 recordsLinked to original sources
PubMed2005

Effect of sodium diclofenac on microcirculation and composition of the lymph during fever reaction.

Therapeutic effect of sodium diclofenac during fever reaction is associated not only with specific modulation of thermoregulation, but also with the increase in the count of lymphocytes transported with the lymph into systemic circulation, stimulation of lymph microcirculation, and improvement of metabolism in the interstitial space. This preparation inhibited kininogenesis and stimulated degradation of kinins. Sodium diclofenac serves as a universal inhibitor of the kallikrein-kinin system.

Animals↗
PubMed2002

Correction of lipid composition of the lymph and blood during immediate type hypersensitivity.

Combination therapy with hydrocortisone and norepinephrine improved resorption and transport functions of the lymphatic system during anaphylactic shock, which was accompanied by a considerable increase in the contents of total lipids, phospholipids, cholesterol, nonesterified fatty acids, and malonic dialdehyde (lipid peroxidation product) in the lymph and blood. It should be emphasized that lipid concentration in the lymph increased to a greater extent than in the blood.

Anaphylaxis↗
PubMed2001

Correction of lymph circulation during immediate hypersensitivity reaction.

We measured lymph flow rate in the thoracic lymphatic duct of dogs with anaphylactic shock receiving mono- or combination therapy with norepinephrine and hydrocortisone. Intensification of lymph circulation improved resorption and transport of metabolic products from the interstitial space through lymphatic vessels and stimulated exchange processes in the blood and tissues during allergic alterations.

Anaphylaxis↗
PubMed1992

[Transferase contents in lymph and blood in fever reaction].

The aim of the present investigation was the study of the content of alanine, asparagine-transaminases, gamma-glutamyl transferase and their isoenzymes, as well as leucine aminotransferase in the lymph of thoracic duct, hepatic and intestinal lymph and peripheral blood in dynamics of fever reaction of various duration in the experiments on rabbits. Irrespective of its duration, the fever was followed by a significant activation of the enzymes in the body fluids. However, in many-day fever reaction, a rise of enzymes level in the lymph was more prolonged than that in the blood. The above studies make it possible to assume that the released enzymes in fever reaction are primarily resorbed by lymphatic capillaries and their activity indices in the blood serum are largely evidenced by the transport function of the lymphatic system.

Alanine Transaminase↗
PubMed1991

[Morpho-functional changes in the lymph nodes during fever reaction].

Lymph nodes (mesenteric, popliteal, cervical) of rabbits in fever reaction of different duration have been studied in our work. As a whole morpho-functional changes in lymph nodes in fever reaction indicate the increase of their functional activity: hyperplasia of lymphatic substance with the growth of lymphocytes number and slightly differentiated lymphoid cells in follicles and paracortical zone, hyperplasia of pulposus bands, the signs of macrophagal reaction and plasmatization of lymph nodes are to be observed and all these create prerequisites for the increase of tensity of cellular and humoral immunity. Simultaneously the signs of destruction of cellular elements--lymphocytolysis in the porta tract and the growth of number of PAS-positive cells in the parenchyma of the nodes take place.

Animals↗
PubMed1991

[Phosphatase activity in the lymph during a fever reaction].

Activity of acid and alkaline phosphatases, as well as isoenzymes of alkaline phosphatase in the lymph of the thoracic lymphatic duct, hepatic lymph and the peripheral blood have been studied on rabbits in the dynamics of the fever reaction of different duration. The fever reaction was followed by enzyme activity increase in all the body biologic fluids. However the degree of increase of their activity in the lymph was greater that that in the blood. Our data indicate that in the transport of phosphatases released from the tissues in the common circulation the essential role is played by the lymphatic system, the resorption and transport functions of which significantly characterise the dynamics and the level of their changes in the blood in fever reaction.

Acid Phosphatase↗
PubMed1991

[Cytological composition of lymph in fever reaction].

This work deals with an investigation into the lymph cytologic composition of thoracic lymph duct of rabbits in fever reaction (FR) of various duration. FR was accompanied by quantitative and qualitative shifts in lymph cytologic composition. There was an alternative rise and fall of the leucocyte number in the first hours of fever. The number of little and medium leucocytes decreased while the number of eosinophiles, insufficiently differentiated cells-blasts, large lymphocytes, prolymphocytes increased. Our investigations revealed a significant role played by the lymphatic system in lymphoid cells mobilization in FR, which is evident by a considerable lymphocyte number gaining entrance to the blood through thoracic duct.

Animals↗
PubMed1990

[Activity of several carbohydrate exchange enzymes in the lymph during fever reaction].

This work includes a comparative study of aldolase enzyme activity, LDG and its isoenzymes in thoracic duct lymph and blood serum of rabbits in fever reaction dynamics of various duration. Irrespective of its duration the fever was followed by a significant activation of investigated enzymes in the body liquids. However, in many day fever reaction a rise of LDG level in the lymph was more prolonged then that in the blood. The above studies make it possible to assume that the released enzymes in fever reaction are primarily resorbed by lymphatic capillaries and their activity indices in the blood serum are largely evidenced by the transport function of the lymphatic system.

Animals↗