Eosinophilic enteritis is an uncommon disease that rarely develops as a surgical emergency. Although it may be associated with infestation by Ancylostoma caninum, its etiology is unknown and often related to a personal or family history of atopy. A transmural involvement may cause intestinal obstruction--more frequently in the jejunum--or even acute abdomen, which may or may not be accompanied by intestinal perforation. The latter two conditions tend to be more commonly associated with ileum disease, causing pain in the lower right quadrant of the abdomen. Patient history, eosinophil count--which may be paradoxically reduced when the disease appears in this way--, ultrasonography, and/or CT lead to the suspicion of this condition before a surgical procedure is considered. A definitive diagnosis, however, must be reached by means of an anatomopathological study. Macroscopically, intestinal loops exhibit a thickened appearance with an elastic consistency. Laparoscopic intestinal biopsy may play a major role in the diagnosis of disease.

Enteritis↗

PubMed1990

[Effects of ranitidine on regenerating parietal cells. A stereologic study].

In this work, we have carried out a stereological and morphological study in order to verify the effects of Ranitidine on regenerating parietal cells. We have used a control group and operated or non-operated groups treated with 2, 10 and 50 mg/kg/day Ranitidine. In operated groups an ulcer was provoked by cauterization with a metallic plate in the gastric fundus. Groups treated with high doses of Ranitidine showed an increase in the connective tissue of the gastric mucosa. The stereological study in treated groups shows a decrease in the parietal volume density, and an increase in the cellular profile. Changes detected in the parietal volume density would originate a decrease in the production of CIH.

Animals↗

PubMed1990

[The effects of pirenzepine on regenerating parietal cells].

In this work, we have carried out a stereological and ultrastructural study in order to verify the action of pirenzepine on regenerating parietal cells. We have used a control group and operated or nonoperated groups treated with 1, 5 and 25 mg/kg/day pirenzepine. In operated groups an ulcer was provoked by cauterization with a metallic plate in the gastric fundus. Parietal cells in operated groups showed mitochondria with altered crests, a fine granular matrix and a large number of tubulo-vesicles. The comparative stereological analysis demonstrates a generalized decrease in the mitochondria, canaliculi and lysosomal volume density, and an increase in the tubulo-vesicle volume density. Changes detected in these cellular structures would originate a decrease in the production of HCl [correction of ClH].

Animals↗

PubMed1987