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Biomedical subjects

F Introna

Publications and source records attributed to F Introna.

At least 19 recordsLinked to original sources
PubMed1991

Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis.

In the past, hemlock poisoning was only known for its neurotoxic effects; quite recently non-neurological features, consisting of rhabdomyolysis and acute renal failure, have been also described. Here we report our experience with these clinical findings, which we frequently observe in accidental hemlock poisoning. Between 1972 and 1990 we studied 18 patients: 17 of them were poisoned by conline (an alkaloid of Conium maculatim) in Apulia (Italy), and one by cicutoxin (the active principle of water hemlock) in New Mexico (USA). In the non-rapidly-fatal cases we tested myoglobinuria, serum muscle enzymes, and renal function. In the patients with acute renal failure we performed microscopical examination of kidney specimens; immunohistochemistry was carried out to identify myoglobin and actin in tubules. Coniine was detected in urine, serum, or tissues. Neurological features were present in all of our cases: coniine had a curare-like effect on the neuromuscular junction, whereas cicutoxin was convulsant on the central nervous system. In addition rhabdomyolysis was noted in the 17 subjects poisoned by coniine. Acute renal failure was observed in five patients; it was confirmed by histological evidence of tubular necrosis with intratubular deposition of myoglobin and actin released by rhabdomyolysis. Our cases seem to be the first with histopathologically proven acute tubular necrosis in coniine intoxication. In conclusion, in hemlock poisoning neurotoxic manifestations may be accompanied by rhabdomyolysis and acute tubular necrosis; increased awareness of these clinical features is recommended in order to improve the diagnostic and therapeutic procedure.

Adult↗
PubMed1991

Sarcosaprophagous fly activity in Maryland.

Eighty-six successful rearings of sarcosaprophagous flies characteristic of the first successional insect wave of infestation of a corpse were conducted under field conditions in Maryland. Different species were observed to be active during spring and summer. The development times for the immature stages of each species, with the related temperatures at which the development occurred are reported for both seasons studied.

Animals↗
PubMed1990

Opiate analysis in cadaveric blowfly larvae as an indicator of narcotic intoxication.

Specimens of liver were collected from 40 cases in which the cause of death had been determined to be opiate intoxication. Rearings of Calliphora vicina larvae were then promoted on the decomposing liver. A control group of 10 decomposed liver specimens from non-opiate deaths was treated similarly. Analysis of larvae and liver for opiates (morphine) was conducted by radioimmunoassay. Good qualitative and quantitative correlation was observed in both the positive and negative groups. Regression analysis comparing the concentrations of opiates found in the larvae with those found in the liver in the positive group resulted in a correlation of r = 0.790.

Animals↗
PubMed1989

Suicide from multiple gunshot wounds.

Nine cases of multiple-shot suicides (suicides involving more than two gunshot wounds) examined in the last 6 years at the Office of the Chief Medical Examiner. State of Maryland, are reported. All victims, with the exception of one, were white: three were women and six were men, with ages ranging from 22 to 81 years. For each case, the results of the scene investigation, the ammunition used, and the autopsy and toxicological findings are described. Each victim suffered 3-5 gunshot wounds. The most common site for the gunshot wounds of entrance was the precordial region, followed by the left chest, the head, and the abdomen. Gunshot wounds were rarely localized exclusively to the head, whereas gunshot wounds scattered on different classic suicide body sites or all confined to the precordial region and the left chest were common. A distinction between instantaneously lethal targets, rapidly lethal targets, and targets of secondary importance is provided, and the guidelines for the proper determination of a multiple-shot suicide are presented.

Abdominal Injuries↗
PubMed1989

Antifreeze (ethylene glycol) intoxications in Baltimore. Report of six cases.

Records of the Office of the Chief Medical Examiner (OCME) for the State of Maryland were reviewed for all deaths related to acute ingestion of antifreeze (ethylene glycol [EG]) occurring between December 1985 and December 1987. Six cases were identified. In three cases, the manner of death was classified as undetermined, in two suicide, and in one case the intoxication was considered to have contributed to death, but was not the main cause. Clinically, the hospitalized subjects exhibited primary metabolic acidosis with hypocalcemia, hyperglycemia, and an elevated anion and osmolar gap. At autopsy, the findings related to EG ingestion were typical of a non-specific drug intoxication. Histological examinations in five cases demonstrated the presence of calcium oxalate crystals in the renal tubules; in three cases extensive renal tubular necrosis appeared related to the survival time. The toxicological analysis in three cases revealed lethal EG levels in the blood.

Adult↗
PubMed1989

The "mini-packer" syndrome. Fatal ingestion of drug containers in Baltimore, Maryland.

We report seven fatalities resulting from the ingestion of illicit drugs packaged in condoms, rubber balloons, or plastic bags which were observed in the last 4 years at the Office of the Chief Medical Examiner, State of Maryland. All the victims, with the exception of one, were men ranging in age from 19 to 37 years. There was no racial predominance. No drug paraphernalia was found at any scene. In two cases, seizure-like activity was documented. One victim had recently returned from Nigeria; therefore, Lassa fever was initially suspected. Two of the victims were "body packer" contrabanders who had just arrived from Africa. They used body cavities to hide large amounts of heroin to avoid U.S. Customs. The other five cases were "mini-packers," small-time illicit drug dealers who had swallowed a single bag of cocaine to avoid police detection. The possible mechanism of leaking or rupture of the latex container is discussed.

Adolescent↗
PubMed1986

Computer-aided skull/face superimposition.

By use of a special optical device coupled with a TV camera to match a skull and a photograph of a face, superimposition for the purpose of personal identification was performed in controlled situations. A computer-aided method to evaluate the fit of the superimposition has been outlined by means of an original Shape Analytical Morphometry (SAM) software package yielding analytical descriptions by kth-order poly-nominal equations and Fourier harmonic analysis. The match was carried out by using point-cross error and sum of differences for the Fourier set amplitude. A final comprehensive evaluation exhibited marked differences between congruent and noncongruent superimpositions.

Face↗