Biomedical subjects

F Iorio

Publications and source records attributed to F Iorio.

At least 19 recordsLinked to original sources

PubMed2001

Papillary muscle rupture and pericardial injuries after blunt chest trauma.

Non-penetrating cardiac trauma resulting in mitral valve rupture is uncommon, requiring a high degree of suspicion for diagnosis. Sudden and severe mitral regurgitation, unless surgically corrected rapidly lead to congestive heart failure and death. We report a patient with traumatic rupture of the antero-lateral papillary muscle of the mitral valve and pericardial injury, after a lateral blunt chest trauma, who successfully underwent emergency mitral valve replacement.

Adult↗

PubMed1996

Muscular uptake of Tc-99m MIBI and TI-201 in Duchenne muscular dystrophy.

Lack of dystrophin, a protein localized to the inner surface of the sarcolemma of the muscle fiber, is the cause of Duchenne type muscular dystrophy. Plasma membrane damage of the muscular fiber occurs, followed by Ca++ influx into the fibers. There is severe mitochondrial damage in dystrophic but still viable fibers. Five children aged 5-7 years were studied with MRI, TI-201, and Tc-99m sestamibi scintigraphy of the thighs. These three methods showed that the sartorius is the least damaged muscle in Duchenne type muscular dystrophy. MRI showed mild damage of adductors and quadriceps; TI-201 scintigraphy showed a marked reduction of radioactivity in the same muscles; Tc-99m sestamibi uptake occurred only in the sartorius muscle; the quadriceps was not imaged and adductors showed a faint image. A decrease of water in muscular fibers as well as fatty fibrous substitution, occurs after death of the fibers, whereas plasma membrane and mitochondrial damage reduced the uptake of tracers when the fiber is still viable. The interesting mismatch between sestamibi and TI-201 can be explained by considering that the cellular mechanism of uptake and retention of Tc-99m sestamibi involves both plasma membrane and mitochondria, whereas the uptake of TI-201 is only affected by plasma membrane damage.

Child↗

PubMed1995

Hemimegalencephaly, hemihypertrophy and vascular lesions.

UNLABELLED: We report on two children with hemihypertrophy and ipsilateral hemimegalencephaly. Vascular lesions in one were consistent with a diagnosis of the Klippel-Trénaunay-Weber Syndrome. MRI performed in the first days of life and at 1 month of age revealed the presence of the neuronal anomaly. CONCLUSION: The occurrence of hemimegalencephaly in our patients indicates that hemihypertrophy and vascular dysplasia are pathogenetically related phenomena of a continuous spectrum in which this brain disorder may appear.

Blood Vessels↗

PubMed1995

Vulvo-vaginitis and reproduction.

The main micro-organisms able to interfere with the reproductive function have been considered. In particular, the problems concerning the vaginal environment and its interactions with spermatozoa, immunological aspects and contraception. Lastly, reference has been made to methods of prevention and study in the field of diagnostics and of clinical management.

Bartholin's Glands↗

PubMed1994

[Increase of paraovarian cysts. Differential diagnosis, macroscopic and microscopic aspects and role of laparoscopy].

The authors, by means of a literature review, report the essential findings on the increase of paraovarian cysts. They report the study on 15 women with paraovarian cystic lymphangioma. At the end the authors underline the macro and microscopic aspects of considered cases for a differential diagnosis with the most common cystic increase of the area.

Adult↗

PubMed1994

Cyto-histological aspects of chorionepithelioma in fluorescence.

The Author illustrates cytochemical and histochemical pictures of the chorion-epithelioma, which the fluorochromization with orange acridine, according to the Bertanlanffy's method, gives with extreme clearness. The intense colouring of both nucleic acids, DNA and RNA indicates a lively functional activity and elevated trophism of the trophoblastic cells.

Acridine Orange↗

PubMed1990

[Echocardiokimography and scintigraphy with Tc-MIBI in left ventricular asynergy in chronic myocardial infarct. Comparison of these methods].

The study compared echocardiography, specially echocardiokimography, and myocardial scintigraphy in the evaluation of the extent of chronic myocardial infarction. Eighteen subjects were enrolled and the following examinations performed: ECG, M- and B-mode echocardiography, echocardiokimography and myocardial scintigraphy with Tc-MIBI, a new perfusion radionuclide agent. We concluded: 1) accordance between the two kinds of methods; 2) specificity of echocardiokimography; 3) advantage in using both methods, specially with MIBI scintigraphy.

Adult↗

PubMed1990

[Surgical correction of atrioventricular canal without heart catheterization].

In our department, 35 patients with atrioventricular canal underwent elective surgery between June 1983 and May 1989. The diagnosis was based on clinical and echocardiographic assessment without cardiac catheterization. Nineteen patients (age 2-12 years; mean 6.6 years) had a partial atrioventricular canal and 16 (age 5-8 months; mean 7 months) presented a complete atrioventricular canal. The echocardiographic diagnosis was confirmed at surgery in all but one patient (2.8%). The latter was diagnosed as having a complete canal but at surgery a transitional canal with a restrictive ventricular septal defect was found. We based our patient selection on the natural history which excluded cases with early heart failure and pulmonary hypertension. We also relied on an accurate morphological study using two-dimensional echocardiography which excluded cases with associated cardiac malformations. Our recent experience (1986-1989) showed that 50% of the patients with complete canal and 60% of patients with partial canal underwent surgery without cardiac catheterization.

Age Factors↗

PubMed1989

[Nuclear magnetic resonance and positron emission tomography: diagnostic potential in tissue characterization].

Nuclear magnetic resonance (NMR) and positron emission tomography (PET) are among the most advanced methodologies providing, with different physical approaches, diagnostic images of the body. In this framework, NMR and PET are particularly well known, not only for the high quality of their present results, but also for the expectations of further developments at clinical and diagnostic level. Common feature of NMR and PET is the capability of associating the anatomical image with information on the physico-chemical and/or biochemical properties of tissues. NMR imaging (MRI) is in fact based upon the acquisition of signals, whose intensities indirectly but closely depend upon particular physico-chemical and biophysical properties of biological tissues. NMR spectroscopy (MRS) and PET allow, on the other hand, quantitative studies on metabolic reactions, as they occur in intact tissues, in vivo and in situ. This review is aimed at summarizing the basic principles of tissue characterization by NMR and PET and discussing their perspectives of clinical application. Emphasis will be given to the special requirements of tissue characterization by these methodologies, referring to the need of improving accuracy and precision of measurements, as well as at evaluating, on a quantitative basis, the performance of the equipment.

Chemical Phenomena↗

PubMed1989

Assessment of peritoneal spread of tumor by scintigraphy. A case report.

A case of peritoneal scintigraphy performed in a patient eligible for peritoneal locoregional treatment with previous positioning of an implantable device is reported. The result of scintigraphy has played a major role in the diagnosis of adhesion and thus in the subsequent therapeutic approach. Indications for peritoneal scintigraphy in the preliminary stage of locoregional treatment by completely implantable devices, are also briefly discussed.

Adenocarcinoma↗

PubMed1988

Equilibrium radionuclide ventriculography in Duchenne's cardiomyopathy.

Rest and stress (handgrip) equilibrium radionuclide ventriculography was performed in 20 patients with Duchenne muscular dystrophy. The mean value of LVEF was normal, but two patients showed values below 35% and another two patients values over 70%. Mean regional wall motion values were less than 2 in lateral (posterior and inferior) and septal walls. Handgrip usually produced a reduction of LVEF and regional wall motion: in three cases severe decrease of motility was observed. Equilibrium ventriculography appears to be useful in the selection of patients with high functional cardiac involvement, integrating the characteristic ECG and echography, and, perhaps, in the assessment of myocardial tolerance to physical therapy.

Adolescent↗

PubMed1988