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Biomedical subjects

F J Darby

Publications and source records attributed to F J Darby.

At least 19 recordsLinked to original sources
PubMed1985

Effects of 1,2-dibromoethane on glutathione metabolism in rat liver and kidney.

There are few reports of the effects of glutathione-depleting agents administered for periods longer than 24 hr on the turnover of glutathione (GSH) in mammalian tissues. Studies of such effects are important in relation to the protection of tissues from damage from, for example, reactive metabolites derived from xenobiotics. In the investigation described here, 1,2-dibromoethane dibromide)-a widely used insecticide, nematocide, fungicide and petrol additive, which is hepato- and nephrotoxic-was administered to rats and the effects on non-protein thiol contents and GSH-related enzyme activities were determined in liver and kidney. The classical GSH-depleter diethylmaleate was used in parallel studies for comparative purposes.

Animals↗
PubMed1977

The treatment of erythropoietic protoporphyria. Experience with beta-carotene.

In a group of 19 subjects suffering from erythropoietic protoporphyria the administration of beta-carotene appeared to produce improvement based on a subjective assessment of alterations in exposure times required to produce the symptoms and signs of the condition. This clinical improvement however failed to show a direct correlation with the prophyrin levels in blood and faeces, or with the estimation by phototesting of the minimal response dose within the action spectrum of 400-600 nm.

Adolescent↗
PubMed1975

The analysis of paraquat in urine by high-speed liquid chromatography.

The paraquat content of urine can be directly determined by high-speed liquid chromatography using ultraviolet spectrophotometric detection. The method separates paraquat (and diquat) from the ultraviolet-absorbing components of urine and no extraction or pre-treatment of the sample is required prior to analysis. Concentrations down to 100 mug/1 of paraquat in urine were determined. Quantitative results are in good agreement with those obtained by a colorimetric method. Diquat does not interfere with the analysis of paraquat, and it would also be possible to analyse diquat in paraquat-containing urine.

Absorption↗
PubMed1971

Changes in drug-metabolizing activities in the livers of suckling rats as a result of treatment of the lactating mothers with phenobarbitone and chlorpromazine.

1. Lactating female rats were treated with phenobarbitone or chlorpromazine. 2. Hepatic microsomal fractions from the suckling offspring were studied to see if changes had occurred in the rates of drug metabolism. 3. Treatment with phenobarbitone significantly increased the cytochrome P-450 concentration, the activity of NADPH-cytochrome c reductase (EC 1.6.2.3) and the rates of metabolism of aniline, ethylmorphine and [2-(14)C]pentobarbitone. 4. Treatment with chlorpromazine produced only small increases in the cytochrome P-450 concentration and the rate of hydroxylation of aniline.

Aniline Compounds↗