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F J Fierro

Publications and source records attributed to F J Fierro.

11 recordsLinked to original sources

The relationship between the free pool of proline and collagen content in human liver cirrhosis.

The free proline, free glutamic acid, and total collagen contents of the livers of cirrhotic and noncirrhotic patients were determined. The amounts of free proline in the sera of the patients were also determined. The results indicated that certain metabolic changes occurred in cirrhotic livers of humans that were similar to the metabolic changes observed previously in CCl(4)-induced cirrhosis in the rat. The amount of free proline was coordinate with the increase in total collagen, and both were inversely related to the amount of free glutamic acid. The average proline concentration in sera of cirrhotic patients was not higher than that of non cirrhotic patients, suggesting that the metabolic alteration noted above is a local event in the liver related to fibrogenesis. These and other results suggest that the pool size of free proline may play a prime role in regulation of collagen biosynthesis in liver cirrhosis.

Autopsy

[Hepatic hamartoma. Study of a case].

The case of a 9 year-old is presented having a mesenchymal hepatic hamartoma. It was diagnosed following Edmondson's classification criteria. Pertinent literature was studied and we found this case may represent the number 30. Useful laboratory analyses are mentioned for the management of these cases and a short preoperative study is emphasized according to the general opinion of pediatric surgeons.

Child