Biomedical subjects

F J Frey

Publications and source records attributed to F J Frey.

166 records · Page 10Linked to original sources

PubMed1977

[Proteinuria and kidney transplantation. A quantitative immunochemical study of 7 protein clearances during the first 50 days following implantation of cadaver kidney].

During the initial 50 days following transplantation of a cadaver kidney into 8 patients, determinations of 7 individual protein clearances were performed twice a week. This, the first posttransplantation investigation of single protein clearances utilizing unconcentrated urine, was made possible by the highly sensitive electroimmunodiffusion method of LAURELL [24]. The following results were obtained: 1. Kidney implantation was immediately followed by glomerulo-tubular proteinuria. In patients exhibiting good transplant tolerance the tubular proteins disappeared from the urine by the 43rd day at the latest; on the other hand, excretion of the glomerular proteins transferrin and albumin continued. In patients without complications the proteinuria was already highly selective by the 7th day (70 degrees). 2. In 5 of 8 patients there was a change in the proteinuria pattern during the rejection crisis: glomerulo-tubular proteinuria occurred three times and glomerular proteinuria twice. In two of these cases there was a change in the selectivity. 3. Patients with good tolerance showed plasma prealbumin levels which increased as a function of the time lapse since transplantation. 4. The plasma concentration of retinol-binding protein did not vary following transplantation and remained at 16.8 +/- 2.8 mg% in patients with uneventful course and at 18.5 +/- 4.9 mg% in patients with transplant rejection reactions, both values being markedly above the norm (4.7 +/- 1.1 mg%, [1 SD]).

Adult↗

PubMed1976

[Radiological, biochemical and clinical aspects of uremic osteopathy in patients with long term dialysis].

The clinical, biochemical and radiological signs of uremic osteopathy in 25 patients dialyzed at the dialyzing unit of the Medical Policlinic of the University of Berne are described. Comparison, mainly of radiologic signs, with the published experience of other centers shows a relatively high frequency of nonsymptomatic osteopenia and metastatic and vascular calcifications in our patients, even though their serum calcium and phosphorous concentrations were kept relatively normal. The frequencies of radiologic alterations in other dialyzing units reported in the literature differ widely from one center to another; this may be due to different technology, but even more to varying evaluation of the findings by different radiologists.

Adult↗

PubMedDate not supplied

Risk of infectious complications in patients taking glucocorticosteroids.

The association between corticosteroid therapy and subsequent infections was calculated by pooling data from 71 controlled clinical trials. The overall rate of infectious complications was 12.7% in the 2,111 patients randomly allocated to systemic corticosteroids and 8.0% in the 2,087 controls (relative risk [RR], 1.6; 95% confidence interval [CI], 1.3-1.9; P less than .001). The risk of infection was particularly high in patients with neurologic diseases (RR, 2.8; 95% CI, 1.9-4.3; P less than .001) and less pronounced in patients with intestinal (RR, 1.4; 95% CI, 1.1-1.7; P = .02), hepatic (RR, 1.4; 95% CI, 0.9-2.3; P = .25), and renal (RR greater than 1; P = .03) diseases. The rate was not increased in patients given a daily dose of less than 10 mg or a cumulative dose of less than 700 mg of prednisone. With increasing doses the rate of occurrence of infectious complications increased in patients given corticosteroids as well as in patients given placebo, a finding suggesting that not only the corticosteroid but also the underlying disease state account for the steroid-associated infectious complications observed in clinical practice.

Adult↗

PubMedDate not supplied

Marked interspecies differences between humans and pigs in cyclosporine and prednisolone disposition.

Pigs have been used extensively in various transplantation protocols. Immunosuppressive therapy is usually performed by steroids and cyclosporine A (CyA). For rational dosage of these xenobiotics, their pharmacokinetics should be characterized. Therefore, we investigated the kinetics of prednisolone, an immunobiologically active steroid, after oral and iv administration, and of CyA, after oral and iv dosing, in seven pigs and compared these results with those obtained in 20 renal transplant patients. The mean area under the blood concentration versus time curve of CyA (HPLC measurements) was lower in pigs than in humans after oral (67 +/- 31 micrograms/ml x min vs. 296 +/- 101 micrograms/ml x min) and after iv (358 +/- 71 micrograms/ml x min vs. 858 +/- 292 micrograms/ml x min) doses of CyA. Compared to humans, pigs had lower concentrations of total prednisolone--assessed by HPLC--after oral prednisone (7.1 +/- 4.3 micrograms/ml x min vs. 297.9 +/- 75.6 micrograms/ml x min) and after iv prednisolone (26.8 +/- 9.5 micrograms/ml x min vs. 373.3 +/- 77.7 micrograms/ml x min). The plasma concentrations of both agents, lower in pigs than in humans, were attributable to an increased volume of distribution, an increased clearance, and more of a diminished systemic availability in pigs than in humans. Thus, to obtain the same target concentrations of CyA and prednisolone in both species, pigs require about 2 to 4 times higher iv or oral doses of CyA and 10 to 30 times higher iv or oral doses of steroids.

Administration, Oral↗