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Biomedical subjects

F J Jacobs

Publications and source records attributed to F J Jacobs.

11 recordsLinked to original sources
PubMed2006

Genomic and transcriptional analysis of protein heterogeneity of the honeybee venom allergen Api m 6.

Several components of honeybee venom are known to cause allergenic responses in humans and other vertebrates. One such component, the minor allergen Api m 6, has been known to show amino acid variation but the genetic mechanism for this variation is unknown. Here we show that Api m 6 is derived from a single locus, and that substantial protein-level variation has a simple genome-level cause, without the need to invoke multiple loci or alternatively spliced exons. Api m 6 sits near a misassembled section of the honeybee genome sequence, and we propose that a substantial number of indels at and near Api m 6 might be the root cause of this misassembly. We suggest that genes such as Api m 6 with coding-region or untranslated region indels might have had a strong effect on the assembly of this draft of the honeybee genome.

Allergens↗
PubMed2001

Disinfection of wooden structures contaminated with Paenibacillus larvae subsp. larvae spores.

AIMS: The aim of the study is to examine the disinfection of wood contaminated with Paenibacillus larvae subsp. larvae spores, in order to find a practical decontamination method for hive materials. METHODS AND RESULTS: The number of viable spores recovered after the treatment, on the surface by swabbing, and in the deeper parts of the wood by scraping, was used to test the efficiency of the disinfection. Our results indicate that chemical disinfection is only complete when high concentrations (> 50%) of the disinfectant are used. Heat treatment in general was found to be very effective. The scorching of wood was not satisfactory as it only killed spores at the surface. CONCLUSION: Complete disinfection is only possible with some heat treatments or by using high concentrations of chemical disinfectants. SIGNIFICANCE AND IMPACT OF THE STUDY: This study puts forward some methods that can provide complete decontamination, which is necessary for an effective control of American foulbrood disease.

Animals↗
PubMed2000

Maxillofacial hydatid cysts.

We report 2 cases of hydatid cysts occurring in the submandibular gland and buccal submucosa, respectively. Our first case occurred in the submandibular salivary gland of a 20-year-old woman and the second involved the buccal submucosa of a 6-year-old boy. Both diagnoses were made after the excision of the lesions. Both patients were evaluated after surgery, and both were followed up, but no other organs were involved.

Adult↗
PubMed2000

Calcifying epithelial odontogenic tumor with intracranial extension: report of a case and review of the literature.

The calcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasm, possibly of stratum intermedium origin and occurring predominantly in the mandible of adults. The treatment varies, depending on its size, location, and histology. A case of an advanced CEOT arising in the maxilla with intracranial extension is reported. The report is supplemented by a review of the literature.

Blindness↗
PubMed1993

Prevalence of markers for human immunodeficiency, hepatitis B and hepatitis C viruses in maxillofacial and oral surgery patients at Medunsa.

Information on the incidence of human immunodeficiency virus (HIV) and hepatitis B (HBV) and C (HCV) virus infections is needed for the planning of preventative measures against the spreading of these blood borne pathogens through treatment in the clinic. A survey was conducted to determine the incidence for 180 patients attending the maxillofacial and oral surgery clinic at the Medunsa Dental Hospital. Antibodies to HIV were found in 1.1 per cent. Hepatitis B surface antigen in 2.8 per cent and Hepatitis B core antibodies as the sole marker in three patients who tested positive for HBV-DNA. The prevalence of anti-HCV was 1.1 per cent. The presence of these infections indicates that there is a need for dental health care workers to comply with all recommended precautionary measures, including immunization against hepatitis B.

Adolescent↗
PubMed1991

Intravelar veloplasty: surgical modification according to anatomical defect.

The patient is often left with an oro-nasal fistula after the intravelar veloplasty procedure for the primary closure of the hard and soft palate cleft. The junction between the hard and soft palate is submitted to maximal tension during this procedure and is where the fistula most often occurs. The primary intravelar veloplasty procedure is discussed and 7 surgical modifications are introduced. The aim of these modifications is the prevention of an oro-nasal fistula and each is specifically adapted according to the existing anatomical form and defect of the cleft palate. The surgical modifications are divided into 2 main groups: those based on localised swivel flaps and those based on distant flaps.

Age Factors↗
PubMed1989

Ornithine-vasopressin gangrene and reconstruction of the upper lip. Case report.

A bilateral cleft lip and palate case received ornithine-vasopressin intra-operatively in preparation for a vasoconstricted field of the various lip segments prior to the repair of the cleft lip. A cyanotic tinge appeared immediately. This eventually led to total necrosis of the upper lip. Various relevant blood tests were done and a mild thrombocytosis was found. Surgical reconstruction of the upper lip was performed by means of a forked cross-lip flap--the main blood supply coming from the columella--as well as by means of an inferiorly pedicled cheek flap from the para-nasal area.

Cleft Lip↗
PubMed1989

[Primary intravelar vestibuloplasty--adaptation of surgical modification of the anatomical defect].

Oro-nasal fistulae often occur after the primary closure of the hard and soft palate cleft and in particular at the junction between the hard and soft palate. This is the area where maximal tension is exerted during the intravelar veloplasty closure procedure. Six surgical modifications of the primary intravelar veloplasty technique are described and each is specifically adapted according to the existing anatomical form and defect of the cleft soft palate, so that the occurrence of an oro-nasal fistula may be prevented. The surgical procedures may be divided into two main groups, namely those which are based on a localized swivel flap and those where remote flaps are used.

Cleft Palate↗