Biomedical subjects
Publications and source records attributed to F J Krause.
The authors report the case of a young patient suffering from plasmacellular osteomyelitis of the thoracic spine, a unusual localisation of this type of chronic osteomyelitis. They discuss the role of imaging diagnostic modalities in this disease, focussing on MRI.
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Percutaneous, catheter-mediated lysis was performed on 56 patients with acute to subacute thrombosis of the superficial femoral artery (Fontaine stage IIb to IV). One half of the patients received rt-PA, the other half urokinase. The clinical parameters of the two groups of patients were largely the same. The therapeutical results were, at about the same treatment costs, better in the rt-PA patients group, in particular with regard to the considerably shorter average treatment period, which lasted on the average for 2 hours in the rt-PA group, vs. 6 hours in the urokinase group. The recanalisation rate was also higher in the rt-PA group (86%) vs. 75% in the urokinase group.
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Muscular clearance as the maximum blood flow in the M. tibialis anterior was determined with 133Xe in 78 patients before and after percutaneous transluminal angioplasty (PTA) of the femoral artery. The increase in maximum blood flow after successful PTA was 33.1%, which is consistent with the results of other investigators. In contrast to the clinical findings (OAD state according to Fontaine) obtained before and after PTA, the muscle clearance worsened in 42.6% of the cases studied. In 85% of the patients, the angiographic findings (stenosing arteriosclerosis of the A. tibialis anterior) explained the cause of this observation; these findings should therefore be available before the muscle clearance is studied.
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Thromboxane concentrations were investigated in the arterial plasma of 44 patients (25 smokers, 19 nonsmokers) with chronic obstructive arterial disease (COAD) of the lower extremities, documented by angiography. The thromboxane levels were measured by radioimmunoassay. The results indicate that smokers with COAD have significantly higher thromboxane levels than nonsmokers with COAD. The potential effect of nicotine on thromboxane is discussed.
Two cases of giant cell arteritis are reported. Angiography was performed to obtain information about the extent of arterial lesions (case 1). In the second case angiography was a guide to diagnosis. Differential diagnostic considerations and the value of angiographic examination are discussed.
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21 patients were examined after different, mostly peripheral vessel operations by intravenous angiography in combination with photographic subtraction. In all cases there was a diagnostic reliability on the documented findings. Structure of vessel-side, morphology of stenoses, formation of a collateral circulation, functioning of bypasses and arteriovenous shunts could be judged sufficiently by the conventional intravenous subtraction angiography (ISA). As a convenient method for the control of the arterial vessel side after vessel operation and angioplasty, the ISA is a suitable method when the digital subtraction angiography is not available. The image quality of the ISA at present is at least equivalent to that of the DVSA .
Isolated tuberculous foci of the sternum are rare. In a period of 26 years (1955 to 1981) we have treated ten sternal lesions surgically in our clinic. Eight of these were tuberculous. The clinical material (three females, five males) is described, including diagnostic and therapeutic details. The frequency, localisation, clinical features, diagnosis, treatment, prognosis and differential diagnosis of specific sternal infections are discussed and the relevant literature is reviewed.