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Biomedical subjects

F J Mallen

Publications and source records attributed to F J Mallen.

5 recordsLinked to original sources
PubMed1986

Retinal arteriolar occlusion in multiple sclerosis.

A 25-year-old white man presented with acute multiple sclerosis manifested by right blindness, difficulty urinating, and paresthesias and weakness of both legs. Retinal examination revealed a distal occlusion of the descending branch of the superior temporal arteriole leading to an area of retinal ischemia of the right eye. The optic disc was edematous, and there were focal areas of periphlebitis. All retinal signs resolved in three weeks, and the only abnormality that persisted was a pale right optic disc. The finding of small arteriolar disease is unusual and may represent another possible pathogenetic mechanism in multiple sclerosis.

Adult↗
PubMed1979

Iris involvement in granulocytic sarcoma.

A 6-year-old boy with a diagnosis of acute myeoblastic leukemia in remission developed iris infiltration accompanied by uveitis, hypopyon, and vitreous hemorrhage, which was initially unilateral, later becoming bilateral. Pathologically, the eyes showed leukemic infiltrates in the conjunctiva, episclera, sclera, ciliary body, trabecular meshwork, canal of Schlemm, choroid, vitreous, and the iris. Leder stain studies showed positive esterase activity, indicating granulocytic sarcoma. Granulocytic sarcoma may appear intraocularly as iris nodules. These iris nodules may be the initial manifestation of granulocytic leukemia.

Antineoplastic Agents↗
PubMed1977

Cilioretinal artery occlusion associated with oral contraceptives.

Visual acuity in a 17-year-old girl who took norethindrone with mestranol (Ortho-Novum) for eight months decreased to 6/9 (20/30) in the left eye. Ophthalmoscopically, retinal edema was temporal to the disk and white plaques were in each of two branches of cilioretinal artery. A superior centrocecal scotoma corresponding to the area of edema was present. After the patient discontinued use of the drug, visual acuity improved to 6/6 (20/20).

Adolescent↗