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Biomedical subjects

F J Martínez-Tello

Publications and source records attributed to F J Martínez-Tello.

11 recordsLinked to original sources
PubMed2002

Giant cell reparative granuloma of the occipital bone.

Giant cell reparative granuloma (GCRG) is a non-neoplastic fibrous lesion with unevenly distributed multinucleated giant cells, areas of osseous metaplasia and hemorrhage. The small bones of the hands and feet are the most common sites, followed by the vertebral bodies and craniofacial bones. In the craniofacial bones GCRG has been reported in the temporal bone, in the frontal bone and paranasal sinus. However, to the best of our knowledge no case has been reported in the occipital bone. We report on the imaging findings and pathological features of a GCRG of the occipital bone and discuss the differential diagnosis of this entity in this particular location, especially with giant cell tumor because of the therapeutic and prognostic implications.

Bone Diseases↗
PubMed2001

Chest wall hamartoma. Report of two cases with secondary aneurysmal bone cysts.

Chest wall hamartoma is a rare non-neoplastic benign lesion occurring in the neonatal period with particular clinical, radiological and pathological features. Histologically, it is composed of a mixture of bone trabeculae with spindle-cell stroma, chondroblast-like cells, and mature and immature hyaline cartilage. Aneurysmal bone cyst is a benign lesion that may arise secondary to several bone processes, such as giant cell tumor, chondrosarcoma, non-ossifying fibroma or osteosarcoma. We present two new cases of chest wall hamartoma with secondary aneurysmatic bone cyst formation studied with histological and immunocytochemical methods.

Bone Cysts, Aneurysmal↗
PubMed1999

Immunoreactivity in granular cell tumours of the larynx.

OBJECTIVE: To elucidate histogenesis and behaviour of laryngeal granular cell tumours (GCT) and to determine the role of p53 protein expression in these lesions. METHODS: The clinical, pathological and immunohistochemical findings of three cases of laryngeal GCTs are described. RESULTS: All tumours were surgically excised and appeared histologically benign. Pseudoepitheliomatous hyperplasia, mitosis and nuclear pleomorphism were not found in any of the three cases. All lesions were negative for keratin 8, desmin and actin. Only one case stained for collagen IV. Positive staining was found for S-100 protein and CD68 in all tumours. Ki-67 and Bcl-2 staining was confined to occasional cells. p53 reactivity was seen in all tumours; positivity ranged from 35 to 42%. The three patients have remained free of disease without complications up to 10 years after treatment. CONCLUSION: Immunohistochemical findings support benign behaviour and a Schwann cell origin for laryngeal GCT. The expression of p53 by granular cells is unclear but appears to be unrelated to behaviour.

Adult↗
PubMed1998

Salivary gland heterotopia in the lower neck: a report of five cases.

Heterotopic salivary gland tissue (HSGT) represents an uncommon lesion, usually presenting as a discharging sinus in the base of the neck. Diagnostic criteria and embryogenesis of this entity still remain unclear. For the purpose of clarifying both subjects, all lateral cervical anomalies undergoing surgery during a 12-year period were examined. Histological study showed salivary tissue in 10 out of 119 patients. However, only 5 of them accomplished HSGT criteria. This study presents the second largest series to date of undisputed HSGT in the lower neck. Both accessory glands and branchial cleft anomalies should be distinguished from this lesion. Neoplastic transformation in HSGT, although extremely rare, should also be considered.

Child↗
PubMed1992

Pathology.

Explore the source record for details and available documents.

Autopsy↗
PubMed1991

Cardiac abnormalities in the toxic oil syndrome, with comparative observations on the eosinophilia-myalgia syndrome.

Early in the course of studies of the Spanish toxic oil syndrome it was recognized that vascular lesions were a major problem, most logically attributable to endothelial damage by the toxic oil. However, most clinical attention has been directed to the pulmonary complications and the evolution into a scleroderma-like illness later. In this study of 11 victims of the toxic oil syndrome careful postmortem studies of the coronary arteries and conduction system and neural structures of the heart demonstrated major injury to all those components of the heart. Obliterative fibrosis of the sinus node in four cases resembled findings in fatal scleroderma heart disease, and in eight the cardiac lesions resembled those of lupus erythematosus. The more impressive pathologic features involved the coronary arteries and neural structures, which were abnormal in every heart. The arterial disease included widespread focal fibromuscular dysplasia, but there was also an unusual myointimal proliferative degeneration of both small and large coronary arteries in five patients, four of whom were young women. In two hearts, portions of the inner wall of the sinus node artery had actually detached and embolized downstream. Coronary arteritis was rarely found. Inflammatory and noninflammatory degeneration of cardiac nerves was widespread. Fatty infiltration, fibrosis and degeneration were present in the coronary chemoreceptor. In most respects these cardiac abnormalities resemble those described in the eosinophilia-myalgia syndrome caused by an altered form of L-tryptophan. In both diseases there is good reason to anticipate more clinical cardiac difficulties than have so far been reported, and even more basis for future concern, especially relative to coronary disease and cardiac electrical instability.

Adult↗
PubMed1989

Pulmonary hypertension due to toxic oil syndrome. A clinicopathologic study.

Clinical and pathologic findings in seven patients who died of severe pulmonary artery hypertension due to toxic oil syndrome are assessed. These cases correspond to a late stage of evolution of the disease characterized by progressive deterioration in clinical features--increasing dyspnea, chest pain, syncope, and death (in low-output heart failure). The main pathologic pulmonary vascular findings consisted of plexiform lesions, thromboses, and venous lesions. Endothelial damage induced by the toxic agents is suggested as an initial causative mechanism, perpetuated by intimal proliferation and in situ thrombosis. Plexiform lesions appear late and active histologically. This new cause of pulmonary artery hypertension, with pathologic findings similar to those found in primary pulmonary hypertension, may help in understanding the pathophysiology of this unknown disease.

Adolescent↗
PubMed1982

The ultrastructure of conventional, parosteal, and periosteal osteosarcomas.

Twenty-seven osteosarcomas of bone were examined by electron microscopy. Eighteen cases were conventional osteosarcomas, one case was an osteosarcoma that developed in Paget's disease of bone, two cases were metastasis to the lungs of conventional osteosarcomas, five were parosteal osteosarcomas (and the recurrence of one of them), and one was periosteal osteosarcoma. In addition to the basic neoplastic cell, the osteoblast-like tumor cell, seven tumor cell types could be differentiated in varying numbers in the 27 cases examined: (1) chondroblast-like; (2) fibroblast-like; (3) histiocyte-like; (4) myofibroblast; (5) osteoclast-like; (6) malignant multinucleated osteoblast-like; and (7) atypical primitive mesenchymal cells. Moreover, endothelial cells and pericytes were also present. The tumor cells showed common neoplastic features in relation with general cell configuration and fine structures. No cytoplasmic organelle was considered to be cell-specific, and only the amount and distribution of the organelles allowed us to differentiate the above mentioned cell types. The presence of malignant appearing tumor cells with abundant and dilated cisternae of RER, in an intercellular matrix containing collagen fibers with areas of focal collections or puffs of hydroxyapatite crystals, are the most characteristic ultrastructural features of osteosarcoma. However, those features are not pathognomonic and do not allow in all cases the differential diagnosis with osteoid-osteoma and benign osteoblastoma. Fields of chondroblastic, fibroblastic, or fibrohitiocytic character are indistinguishable of chondrosarcomas, fibrosarcomas, or malignant fibrous histiocytoma of bone, respectively. The comparative study of parosteal and conventional osteosarcomas revealed a marked difference in the cell population: fibroblast-like cells and myofibroblasts were the main cell types in parosteal osteosarcoma; on the contrary, myofibroblasts were very scarce or absent in conventional osteosarcomas. This difference may correlate with the better outcome of parosteal osteosarcoma. The ultrastructural features of a periosteal osteosarcoma are reported for the first time. The tumor was comprised mostly of chondroblast-like tumor cells. However, in the more cellular peripheric areas of the neoplasm, the cells were predominantly of the fibroblast-like type and showed anaplastic features.

Bone Neoplasms↗
PubMedDate not supplied

[Branchial cysts with heterotopic salivary tissue in the upper third of the neck].

The presence of heterotopic salivary gland tissue (HSGT) in rather uncommon in the neck. Usually it has been located in its lower third. HSGT in the upper neck is believed to be a rare entity. Two cases of HSGT in the upper neck are presented, with a review of their clinical and histopathological characteristics. The embryologic derivation of salivary tissue and close association with the branchial apparatus are discussed. The possibility of neoplastic transformation must always be considered in these uncommon lesions.

Adolescent↗