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Biomedical subjects

F J Milne

Publications and source records attributed to F J Milne.

87 records · Page 5Linked to original sources
PubMed1976

Pregnancy in renal transplant recipients.

Of the 48 female patients attending the outpatient clinic of the Johannesburg General Hospital Transplant Unit between January 1971 and December 1974, 10 became pregnant. Fifteen pregnancies were recorded, 6 of which ended in abortions. Ten infants were born from the remaining 9 pregnancies and 4 (40%) died in the neonatal period. The main cause of neonatal death was prematurity. One major congenital anomaly, a diaphragmatic hernia, was found. Maternal complications were mild and easily controlled, urinary infection being the commonest. One patient showed a moderate reduction in renal function. Obstruction of labour by the transplanted kidney was not encountered, and the two Caesarean sections were performed for obstetrical reasons unrelated to the renal transplant.

Abortion, Therapeutic↗
PubMed1976

Angiography after renal homotransplantation.

The role of angiography in the investigation of problems encountered among 181 patients who received renal transplants at the Johannesburg General Hospital is analysed. In all, 23 patients underwent arteriography or venography after transplantation for the investigation of problems such as renal dysfunction, hypertension and suspected renal vein or iliofemoral venous thrombosis.

Diagnosis, Differential↗
PubMed1976

Strongyloides stercoralis hyperinfection in a renal allograft recipient.

A patient who had received a renal allograft required intensive immunosuppression for a severe rejection episode. Four months after the graft he died of septicaemia and respiratory failure caused indirectly by a Strongyloides stercoralis hyperinfection. Patients from endemic areas who are to undergo a renal transplant should be screened for the parasite before receiving immunosuppressive therapy. Should this infection occur after transplantation, early diagnosis and treatment with thiabendazole is essential to prevent the high mortality rate associated with Strongyloides hyperinfection.

Adult↗
PubMed1976

Observations on the intraarticular use of corticosteroids in the racing thoroughbred.

A project to determine if intraarticular corticosteroid therapy was deleterious to the racing Thoroughbred was carried out in the 1971, 1972, and 1973 racing seasons. Of 22 horses available for follow-up examination, 6 had radiographic evidence of deterioration; 1 of these was destroyed because of probable corticosteroid-induced arthropathy. The remaining 16 horses did not have any evidence of deterioration. One of the 16, a stakes winner, had been given 12 injections into the left front fetlock during the 3-year period. It was concluded that if proper and careful aftercare is adhered to, intraarticular injections of corticosteroids can be carried out with relative impunity.

Adrenal Cortex Hormones↗
PubMed1976

Left ventricular function in chronic renal failure.

Left ventricular function was studied in 14 patients with end-stage chronic renal failure using non-invasive methods (echocardiography and systolic time intervals). Patients were divided into 3 groups. Group 1 consisted of 5 patients who were normotensive at the time of study and group 2 of 7 patients who were hypertensive when studied. Group 3 consisted of 2 patients: one was receiving propranolol and the other, studied 302 days after renal transplantation, was receiving digitalis for recurrent episodes of cardiac failure. All except the patient receiving propranolol had normal left ventricular function in systole with normal measurements of fractional fibre shortening (% delta S, EF) and normal measurements relating to the velocity of ventricular contraction (mean Vcf, mean velocity of posterior wall motion). Stroke volume and cardiac output were normal in some patients but were increased in patients with fluid overload. Early diastolic compliance of the left ventricle seemed to be normal except in the patient with recurrent cardiac failure. The study provided no evidence for the existence of a specific uraemic cardiomyopathy.

Adult↗
PubMed1975

Changes in oxygen delivery during hemodialysis.

The effect of hemodialysis on oxygen delivery has been assessed in nine patients. During hemodialysis the arterial PO2 decreased from 76.89 mm Hg to 69.03 mm Hg. There was also an increase in pH from 7.39 to 7.49 which resulted in an increase in the affinity of the blood for oxygen. In the absence of compensatory changes this could result in a 17.9% decrease in oxygen delivery. This could be hazardous in patients who are already anemic particularly in the presence of cardiac or respiratory insufficiency.

Adult↗
PubMed1974

The kinetics of hematopoiesis in the light horse. I. The lifespan of peripheral blood cells in the normal horse.

Three Standardbred horses were given 0.2 mg (1 mCi) of (75)selenomethionine intravenously and a second group of three were given 10 mCi of tritiated diisopropylfluorophosphate (0.5 mg) intravenously. Observations on labeled cells were continued for 250 days after radioselenium injection and 160 days after tritium injection. The lifespan of erythrocytes using (75)selenmethionine was 155 +/- 10 days and 148 +/- 7.8 days using tritiated diisopropylfluorophosphate. There was no significant difference at the 10% level between the lifespans, using these labels. The uptake of radioselenium into erythrocytes reached a mean maximum of 11.5% at 82 +/- 18.9 days after injection of the label. There was an elution of from 17.6% of the injected dose of tritium label down to 7.5% eight days after injection of this isotope. From this study both of these labels appear to be satisfactory for determining the erythrocyte lifespan of the horse. The mean time of the curve of mean radioselenium activity of peripheral blood leukocytes for the three horses was 5.54 days and the lifespan of these cells was seven days. The mean lifespan of peripheral blood leukocytes of the three horses after in vivo labelling with tritiated diisopropylfluorophosphate was 17.3 hours. No specific labelling was found in bone marrow or peripheral blood cells at this level of tritium labelling by dipping emulsion autoradiography. The mean lifespan of equine platelets for three horses using radioselenomethionine was 9.2 days and the mean lifespan of equine platelets using tritiated diisopropylfluorophosphate was 6.6 days in a group of three horses.

Animals↗