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F J Paradinas

Publications and source records attributed to F J Paradinas.

At least 37 records · Page 2Linked to original sources
PubMed1992

Genetic evidence that placental site trophoblastic tumours can originate from a hydatidiform mole or a normal conceptus.

The genetic origin of two placental site trophoblastic tumours was established using a Y chromosome-specific and locus-specific minisatellite probes. A gestational origin was confirmed for both tumours. In one case the origin of the tumour was consistent with derivation from a normal female conceptus while the other was shown to arise from a homozygous complete hydatidiform mole, an abnormal conceptus more usually associated with the development of choriocarcinoma.

Adult↗
PubMed1990

Gestational trophoblastic tumours following initial diagnosis of partial hydatidiform mole.

11 patients registered with an initial diagnosis of partial hydatidiform mole (PHM) subsequently required chemotherapy for a gestational trophoblastic tumour. In a retrospective review by histopathological examination and measurement of DNA ploidy, the diagnosis was confirmed as PHM in 5 cases and revised to complete hydatidiform mole in 4; in 2 cases there was no evidence of a molar pregnancy. 4 of the patients with PHM had no other known pregnancy before the gestational trophoblastic tumour and in 2 of these patients the tumour was diagnosed histologically as choriocarcinoma. Not all patients in whom PHM was diagnosed at referring hospitals proved to have the condition. Although the risk of a patient with PHM requiring chemotherapy for gestational trophoblastic tumour is of the order of 1 in 200, compared with 1 in 12 after a complete mole, there is no justification for excluding a patient from follow-up after the evacuation of a PHM.

Adult↗
PubMed1990

Surgery and chemotherapy in the management of placental site tumor.

Since 1977 we have managed seven cases of placental site trophoblastic tumor. All patients were treated with hysterectomy. Three patients had preoperative chemotherapy without evidence of response. One of three patients presenting with no evidence of extrauterine spread and one of four presenting with extrauterine pelvic disease have died from metastatic disease on recurrence. One patient with pelvic disease and lung metastases at diagnosis has residual lung nodules, presumed necrotic, 47 months after completing chemotherapy. She received etoposide, methotrexate, and actinomycin D (EMA) alternating weekly with cyclophosphamide and vincristine (CO). Although surgical excision of placental site tumor remains the treatment of choice, EMA/CO chemotherapy may produce the occasional long-term survivor.

Adult↗
PubMed1990

HTLV-1 associated T-cell lymphoma in a patient with a 10-year history of non-epidermotropic T-cell skin infiltrates.

We report a patient who had non-epidermotropic T-cell infiltrates of the skin for 10 years prior to the development of a HTLV-1 associated disseminated T-cell lymphoma. The presentation and initial course of the lymphoma were unusual and we believe this is the first report of such an association. We therefore feel that patients of Caribbean origin with non-Hodgkin's lymphoma should be tested for HTLV-1 so that appropriate chemotherapy can be instituted at the outset in this poor prognosis group.

Female↗
PubMed1988

Testicular atrophy after oestrogen therapy.

Therapeutic use of oestrogens by males with carcinoma of the prostate leads to testicular atrophy with markedly reduced spermatogenesis after only 21 d (Oshima et al. 1974). Treatment for over a year results in paucity of germ cells, vacuolation of Sertoli cells and reduction in Leydig cells (Lu & Steinberger 1978, Smith & Urry 1985). There is, apparently, no information on the histology of the human testis after more than 1 year oestrogen therapy. We here report changes in testes from five transsexuals treated for periods of up to 5.5 years.

Adult↗
PubMed1986

Early warning skin signs in AIDS and persistent generalized lymphadenopathy.

Distinctive patterns of skin disease other than Kaposi's sarcoma have been in patients with AIDS, in others with persistent generalized lymphadenopathy (PGL) and in a group at high risk of developing AIDS. We found a chronic acneiform folliculitis on the face, back, chest and buttocks, extensive cutaneous fungal infections and a striking neck and beard impetigo. These skin diseases were not present in asymptomatic male homosexual control subjects, 32% of whom were found to have antibodies to human T cell lymphotropic virus type III (HTLV-III). We regard these dermatoses as early warning signs of AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Trial of (+)-cyanidanol-3 in patients with hepatitis B chronic liver disease.

A double-blind controlled trial of 12 months' treatment with (+)-cyanidanol-3 was carried out in 26 patients with chronic hepatitis B liver disease. Treatment did not improve liver blood tests nor histological appearances of the liver, but there was a trend towards reduction of serum titres of hepatitis B surface antigen.

Catechin↗
PubMed1985

Laryngeal neuroendocrine tumour with features of a paraganglioma, intracytoplasmic lumina and acinar formation.

A supraglottic laryngeal neuroendocrine tumour in a 71-year-old female is presented. In addition to the typical features of extra-adrenal paragangliomas it showed unusual, numerous intracytoplasmic lumina and occasional true acini with accumulation of alcian blue and PAS positive secretory product in them which led originally to an erroneous diagnosis of metastatic adenocarcinoma. Ultrastructurally, the tumour was composed of light and dark chief cells containing varying numbers of dense-core secretory granules. Intracytoplasmic lumina and true acini contained microvilli with glycocalyceal material and varying amounts of membranous and amorphous material, possibly secreted via small, smooth-surfaced cytoplasmic vesicles but typical mucin granules were not seen. These features have not been previously described in laryngeal paragangliomas but are seen in endocrine tumours of other sites and have been used as an argument in favour of an endodermal rather than ectodermal origin for endocrine cells in those sites. Laryngeal paragangliomas are often malignant and the presence of spasmodic pain appears to be the most reliable indication of possible malignancy, histological criteria being as yet poorly defined.

Aged↗
PubMed1984

Significance of the 'maturation' of metastases from germ cell tumours after intensive chemotherapy.

A comparison between primary and metastatic germ cell tumours from 38 male patients showed that 19 of 24 metastases with residual differentiated teratoma after adequate therapy came from tumours with teratoma as a component of the primary. The correlation between the presence of teratoma in the primary and the metastases is statistically significant (P less than 0.01) and supports the view that the so called 'maturation' of germ cell tumours is due to selective destruction of anaplastic components in tumours which have already shown an inherent capacity for differentiation. Elevation of the serum concentrations of HCG and AFP on presentation with disseminated disease was significantly related to the presence of morphologically identifiable trophoblast and yolk sac elements respectively in the primary tumours (P less than 0.001). Histological identification and specific mention of teratomatous, trophoblastic and yolk sac elements in reporting germ cell tumours is therefore useful since their presence in the primary correlates with the morphology in the metastases.

Adolescent↗
PubMed1984

Distribution of the Ca (Oxford) antigen in lung neoplasms and non-neoplastic lung tissues.

The Ca (Oxford) antigen was originally isolated from a malignant neoplasm and with few exceptions was reported to discriminate between malignant and non-malignant neoplasms or normal tissues. Using the Ca 1 antibody we have studied the Ca distribution in 54 lung neoplasms and adjacent non-neoplastic lung tissue. Staining of tumours was very focal and the proportion of positive cells varied from about 50% for adenocarcinomas to less than 1% for oat cell carcinomas, which were often negative. Focal cytoplasmic staining can be seen in all neoplasms, whereas membrane staining is mainly seen in their areas of glandular and squamous differentiation. We found consistently strong membrane staining of alveolar type II pneumocytes in non-neoplastic lung. This staining may be useful in differentiating type II cells from alveolar macrophages which only occasionally showed granular cytoplasmic staining, probably due to phagocytosed Ca. Mucin from tumours and bronchi did not stain but there was consistent staining of alveolar serous exudate suggesting extracellular location of Ca.

Adenocarcinoma↗
PubMed1984

Hyperinsulinaemic hypoglycaemia due to chlorpropamide-induced nesidioblastosis.

A 25 year old woman suffering from recurrent attacks of hypoglycaemia underwent a laparotomy for suspected insulinoma. No tumour was found, but histology showed islet cell hyperplasia and nesidioblastosis. Although these changes have been reported as a cause of hypoglycaemia in infants, they are only rarely the cause of hypoglycaemia in adults; in the present case they were found to be the result of covert sulphonylurea administration. The fact that sulphonylureas can cause nesidioblastosis is not well recognised by either physicians or pathologists and it should be considered before "cryptogenic nesidioblastosis" is deemed the cause of hypoglycaemia in adults.

Adult↗
PubMed1983

Chronic liver disease in haemodialysis patients.

Elevated serum alanine aminotransferase (ALT) for more than one year was found in 36 (28.8%) of 125 patients on maintenance haemodialysis. In 10 the ALT returned to normal spontaneously but in 26 it remained high. Liver tissue from 21 patients with high ALT and seven with normal ALT was examined. Statistically significant correlations were found between the mean ALT during the year prior to the biopsy and assessments of the lymphocytic infiltration (p less than 0.001), fibrosis (p less than 0.001) and amount of silicone particles in the liver (p less than 0.001). Epithelioid cell granulomata, lobular and portal macrophages and perivenular fibrosis were related to silicone particles. Lymphocytes were not spacially related to the particles; nevertheless, there was a significant correlation between amounts of silicone and lymphocytic infiltration (p less than 0.01). No associations were found between high ALT, hepatitis B serology, serum ferritin, parenchymal siderosis, propensity to fluid overload, alcohol abuse and HLA-B8.

Adult↗
PubMed1982

High serum vitamin B12 binding capacity as a marker of the fibrolamellar variant of hepatocellular carcinoma.

Ten (9.3%) of 107 patients with hepatocellular carcinoma had considerably increased serum unsaturated vitamin B12 binding capacity. All 10 were young (mean 12 years), had no serum alpha-fetoprotein, and no underlying cirrhosis; all had a longer survival compared with patients without increased serum unsaturated vitamin B12 binding capacity in the study. Seven of the 10 patients had fibrolamellar hepatocellular carcinoma, a recently recognised histological variant, which was found in only one young patient without increased serum unsaturated vitamin B12 binding capacity and no alpha-fetoprotein among the remaining 97. This high degree of correlation between increased serum unsaturated vitamin B12 binding capacity and fibrolamellar hepatocellular carcinoma has not been reported before. Increased serum unsaturated vitamin B12 binding capacity may be of considerable help in diagnosis, prognosis, and monitoring treatment of this well-defined group of patients with hepatocellular carcinoma but no alpha-fetoprotein.

Adolescent↗
PubMed1982

Histological features of skin reactions to human lymphoid cell line lymphokine in patients with advanced cancer.

Lymphokines (LCL-LK) prepared from the human lymphoid cell line RPMI 1788 were injected intradermally into tumour-bearing patients. Biopsies of skin reactions were obtained for histological study from 30 min. to 72 hr, and for comparison, biopsies were taken at similar times of tuberculin reactions in tuberculin-positive patients. The early response to LCL-LK consisted of polymorph adherence to vascular endothelium (at 30 min.) followed by polymorph exudation, oedema and haemorrhage (1-2 hr); mononuclear and eosinophilic leucocyte emigration began at 4 hr; and by 12 hr, when the reaction was maximal clinically, there was widespread pleomorphic leucocytic infiltration of the dermis. At later times (48-72 hr) skin reactions to LCL-LK showed predominantly mononuclear cell infiltration and hypertrophy of vascular endothelium. Electron microscopy at 48 hr revealed perivascular lymphocytes and macrophages. The skin reaction to LCL-LK appeared to superimpose an early component of marked polymorph infiltration, oedema and haemorrhage upon a mononuclear cell exudation similar to that seen in the tuberculin reaction. It was concluded that the later phase of the skin reaction to lymphoid cell line lymphokine in the human bore a close histological similarity to the established tuberculin reaction. The LCL-LK reaction occurred in patients anergic to recall antigens. Its intensity was mainly related to dose and did not vary substantially between different batches of lymphokines.

Dose-Response Relationship, Immunologic↗