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Biomedical subjects

F J Prime

Publications and source records attributed to F J Prime.

11 recordsLinked to original sources
PubMed1979

A clinical trial of choline theophyllinate versus salbutamol with placebo control.

Using a randomized double-blind procedure, seventeen patients with chronic airways obstruction completed a placebo-controlled study to compare bronchodilator effects of single doses of choline theophyllinate 400 mg and salbutamol 4 mg. As determined by a range of spirometric measurements, the effects of the two drugs were remarkably similar and there were no statistically significant differences in any of the parameters measured. Both drugs produced highly significant differences in comparison with placebo response. Side-effects were mainly complaints of digital tremor; this was seen in four of the patients after salbutamol and in less pronounced form in two patients after choline theophyllinate.

Administration, Oral↗
PubMed1979

Inhibition of artifically-induced asthma by reproterol ('Bronchospasmin').

A study was carried out in 25 patients with asthma caused by exposure to occupational antigens to investigate the effectiveness of reproterol in protecting and terminating the bronchoconstrictor response to inhaled antigens. The results of lung function tests showed that the immediate reactions to the provocation test could be reversed by reproterol given either at the time of the reaction or shortly before challenge.

Adult↗
PubMed1977

The bronchodilator effect of NAB 365.

1. Dose response relationships for salbutamol and a new bronchodilator drug NAB 365 have been obtained in patients with reversible airways obstruction. These show that the latter is about one hundred times more potent than the former. 2. NAB 365 has a very long half-life. The implications of this are discussed.

Adult↗
PubMed1977

A study of pulmonary artery pressure, electrocardiography, and mechanocardiography in thoracic scoliosis.

Cardiac catheterisation was carried out in 40 patients with thoracic scoliosis in order to measure the pulmonary artery pressure. Statistical correlations were calculated between these results and the electrocardiographic and mechanocardiographic findings determined on a separate occasion. The pulmonary artery pressure was normal in 72% of subjects. It was inversely correlated with arterial oxygen tension but not with the aetiology, severity, or age at onset of the scoliosis. The accuracy of electrocardiography and mechanocardiography in predicting the pulmonary artery pressure was assessed. The closet correlates were found to be a tall P wave in lead II or III and a prolonged interval between pulmonary valve closure and tricuspid valve opening.

Adolescent↗
PubMed1975

Comparison between the bronchodilator and cardiovascular effects of inhaling 0.5 mg. rimiterol ('Pulmadil') and 0.2 mg. salbutamol.

A comparison between the acute effects of rimiterol (0.5 mg) and salbutamol (0.2 mg.) has been made using metered dose aerosols. In this dosage it was found that the peak effect of the two drugs was the same but that the effect of rimiterol was less prolonged than that of sulbutamol. No increase in blood pressure occurred and heart rate changes were minimal after both drugs. Rimiterol is an acceptable alternative to the short-acting isoprenaline but lacks the cardiovascular effects of isoprenaline and is an alternative to salbutamol where very prolonged action is unnecessary.

Adult↗
PubMedDate not supplied

Lung function in young persons after spinal fusion for scoliosis.

The long-term changes in vital capacity and in total lung capacity after spinal fusion for 43 scoliotic patients are described. The values recorded were seldom lower after surgery but did not show any marked subsequent increases with patient growth. Subsequent increases in volumes are less marked in the group of patients with paralytic scoliosis. These findings suggest that the psychological advantages of improving the patient's appearance by surgery and of preventing any respiratory condition from worsening may be achieved, although the total capacity and vital capacity are not much improved by spinal fusion.

Adolescent↗