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Biomedical subjects

F J Rini

Publications and source records attributed to F J Rini.

6 recordsLinked to original sources
PubMed1988

Cryotherapy for conjunctival primary acquired melanosis and malignant melanoma. Experience with 62 cases.

Sixty-two patients were treated by some combination of cryotherapy and surgery with an average follow-up of 3.3 years for one of the following diseases: focal or diffuse flat conjunctival primary acquired melanosis (PAM) with atypia but without a nodule of melanoma (10 cases); unifocal malignant melanoma with or without focal or diffuse PAM (30 cases); and multinodular/multicentric melanoma with and without PAM (22 cases). Of the ten patients who had PAM with atypia, invasive nodules of malignant melanoma did not develop. A second treatment was required to control the disease in four of the ten patients with extensive or diffuse lesions, and one has mild persistent disease. Of the 30 patients with unifocal nodules of malignant melanoma, 27 remained free of recurrence after one treatment, and 2 are asymptomatic after two treatments. One patient with a thick nodule at presentation required a parotidectomy and radical neck dissection for cervical metastases after recurrence in the conjunctival sac. In the group of 22 patients with multinodular malignant melanoma, only two did not have recurrent disease after one treatment. Of those who received multiple therapies, seven remained free of recurrence for at least 2 years after the last treatment; regional or distant metastases developed in nine; four required exenteration; and eight died. Conjunctival adjunctive cryotherapy avoids exenteration in extensive lesions of pure PAM and in unifocal melanoma, but even after multiple therapies, multinodular malignant melanoma had a 45% rate of metastasis. Metastasis was related to the presence of PAM sine pigmento in four patients (microscopically but not clinically detectable PAM); to the location of the nodules (9 of 10 patients who experienced metastases had forniceal, palpebral, and/or caruncular nodules); to the thickness or depth of invasion of the nodules (greater than 2 mm); and to the development of intralymphatic spread ("in-transit" local metastasis) within the conjunctival sac in six patients. No metastases were encountered among patients with strictly limbal nodules and among five patients with invasive nodules composed of spindle cells in part or in toto. Therapeutic success in this spectrum of melanocytic proliferations is closely correlated with the clinical extent of the disease when initiating definitive therapy.

Adult↗
PubMed1987

The treatment of advanced choroidal melanoma with massive orbital extension.

Four patients, each with a history of choroidal melanoma for more than ten years, became increasingly proptotic secondary to massive extraocular extension of their tumors. Because no metastases were detected during thorough systemic examinations, two patients underwent orbital exenteration. These patients suffered fulminant local orbital regrowth of their tumors at three and six months after surgery and died of distant metastases within ten months of exenteration. A third patient, who underwent a biopsy of the orbital mass via a lateral orbitotomy and received postoperative radiotherapy, died two years afterward. A fourth patient who refused any surgical treatment was followed up for five years after massive orbital disease developed. She died of disseminated disease. The patients who survived the longest had minimal or no surgery.

Aged↗
PubMed1985

Posterior capsule opacification: experimental analyses.

The lenses of New Zealand White and Flemish Giant rabbits were removed using five techniques representative of the different clinical approaches to extracapsular cataract extraction currently employed. Posterior capsule opacification developed in all experimental animals within 6 weeks of the operation. None of the techniques reduced the incidence of the capsular opacification. Histological analyses including immunofluorescent and tritiated thymidine labelling were used to determine the nature of the cellular constitutents of the secondary membrane. The evidence indicates that the opacity is due not only to lens cells remaining after the operation but also consists of cells of nonlenticular origin. The data strongly implicate the anterior uvea as the source of those cells. Furthermore, the findings suggest that posterior capsule opacification is the product of a migration and a proliferation of both cell populations.

Animals↗
PubMed1983

Scanning electron microscopic analysis of radiation cataracts in rat lenses. I. X-radiation cataractogenesis as a function of dose.

Cataracts produced in 4-week-old rats following exposure of the eye to various doses of 185 kVp X-rays, were analyzed 45 days after irradiation by scanning electron microscopy (SEM), as well as by conventional light microscopy (LM). The severity and extent of the ultrastructural damage seen at the LM and SEM levels varied as an increasing function of dose and correlated well with the clinical changes which were scored by slitlamp biomicroscopy prior to preparation. In the early-stage low-dose cataracts, damage was generally limited to the equatorial and posterior subcapsular regions. The late-stage high-dose cataracts were associated with clusters of 4 to 10 microns globules at the poles subcapsularly, massive disruption of the equatorial region and the formation of a granular matrix which extended to the posterior pole. Ultrastructural changes were also noted in the superficial cortical region, while the lenticular nucleus and the residium of the cortex remained unchanged.

Animals↗