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Biomedical subjects

F J Roth

Publications and source records attributed to F J Roth.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Duplex sonographic determination of blood pressure gradient in iliac artery stenoses. Comparison with invasive measurement].

The present study investigates the validity and accuracy of the simplified Bernoulli equation in the duplex-derived determination of pressure gradients across iliac artery stenoses. 28 patients presenting with iliac artery stenoses were examined by both duplex scanning and intraarterial catheter pressure measurement. The catheter-determined and duplex-derived mean pressure gradient was 16 +/- 7 and 14 +/- 7 mmHg, respectively. There was a fairly good correlation between the mean pressure gradients assessed nonsimultaneously by both methods (r = 0.77). The catheter-determined and duplex-derived maximum instantaneous pressure gradient was 53 +/- 16 and 52 +/- 21 mmHg, respectively. The correlation coefficient (r) for the maximum instantaneous pressure drop values determined by the two methods was r = 0.79. The results show that duplex ultrasound predicts mean and maximal-instantaneous pressure gradients with acceptable approximation in patients with iliac artery stenoses.

Adult↗
PubMed1991

[The indications for rotation angioplasty of the a. femoralis superficialis and the a. poplitea. The treatment results in 75 complicated chronic arterial vascular occlusions].

75 patients with difficult occlusions in the superficial and popliteal arteries were treated by the "Rotacs" system. This technique is efficient in treating occlusions longer than 10 cm, with an initial success rate of 60.5%. In primary failed conventional angioplasties Rotacs-PTA was successfully employed in 56% as a second intervention. This is considered to be an advance in PTA technique. In stage II disease the PTA results are better than in diseases of the stages III and IV, which agrees with conventional catheter treatment. In the femoropopliteal overlapping segment the initial successful PTA of short, hard, mostly calcified occlusions was only 33%. The complication rate of Rotacs technique compares with that of the conventional methods.

Adult↗
PubMed1991

Use of duplex scanning in the diagnosis of arteria profunda femoris stenosis.

To evaluate the accuracy of duplex scanning in diagnosing arteria profunda femoris stenoses in patients with concomitant superficial femoral artery occlusions, 123 femoral artery bifurcations were examined in 103 patients. Peak systolic and time-averaged maximal flow velocity parameters were measured in the arteria profunda femoris and compared with independently performed angiography. For detecting stenoses greater than 30% diameter reduction (50% by area) of the arteria profunda femoris, duplex scanning had a sensitivity of 91% and 96%, a specificity of 85% and 98%, a positive predictive value of 86% and 98%, and a negative predictive value of 91% and 96%, for a peak systolic velocity of 180 cm/sec and more, and for a time-averaged maximal velocity of 50 cm/sec and more in the arteria profunda femoris, respectively. The day-to-day variability for peak systolic and time-averaged maximal velocity parameters was low with correlation coefficients between velocity measurements on both days of 0.96 and 0.98 (n = 20), respectively. In 10 patients with arteria profunda femoris stenoses and superficial femoral artery occlusions, undergoing percutaneous transluminal angioplasty of arteria profunda femoris stenosis, the duplex scan revealed a reduction in stenotic peak systolic velocity from 330 +/- 84 to 163 +/- 50 cm/sec and a decrease in stenotic time-averaged maximal velocity from 156 +/- 47 to 54 +/- 17 cm/sec after the interventional procedure. These results show that peak systolic and time-averaged maximal velocities are accurate parameters to detect significant arteria profunda femoris stenosis in patients with superficial femoral artery occlusions.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1991

[Ultrastructural and proliferation studies of human, catheter atherectomy extracted plaque material].

Atherectomy with a Simpson catheter enables a detailed characterization of percutaneously removed human atheromatous plaque material. Cell biological investigations (flow-cytometric analyses, cell type-specific antibodies, immunohistological labelling methods of selected extracellular matrix proteins) are aimed at a comparative characterization of excised material from primary lesions and restenoses to yield further insight into the mechanisms of plaque formation. First results on 17 specimens would like to contribute to a better understanding of the structure and composition of the extracellular matrix and their interaction with cells in atherosclerotic plaques.

Aged↗
PubMed1991

[Contribution of duplex sonography to prediction of pressure drop across iliac artery stenoses].

The present study investigates the validity and accuracy of the simplified Bernoulli equation in the duplex-derived determination of pressure gradients across iliac artery stenoses. Twenty eight patients presenting with iliac artery stenoses could be examined by both duplex and intraarterial catheter pressure measurements. The correlations between mean and maximal-instantaneous pressure gradients assessed by both methods were r = .77 and r = .79, respectively. Duplex scan can be used to predict pressure gradients in patients with iliac artery stenoses.

Arterial Occlusive Diseases↗
PubMed1990

[Local lysis therapy in acute arterial thrombosis].

Acute thrombotic arterial occlusion is a complication of chronic vascular arterial disease. The arteriogram usually reveals a sudden occlusion and the collateral vessels. Treatment with low-dose fibrinolytic therapy is widely accepted. A combination of low-dose fibrinolysis, aspiration embolectomy and angioplasty yields the best primary success rate. In cases of sudden popliteal occlusion and dilating arteriopathy ultrasound sonography should be used to exclude the presence aneurysm which is a contraindication for fibrinolysis. There is a high risk of peripheral embolisation, in the presence of an aneurysm and this may cause severe deterioration of the arterial blood supply.

Angioplasty, Balloon↗
PubMed1989

Low-speed rotational angioplasty in chronic peripheral artery occlusions: experience in 83 patients. Work in progress.

Between December 1986 and October 1988, 83 patients with chronic peripheral artery occlusions were treated with a new technique. In 56 patients, the superficial femoral artery was completely occluded; in 21 patients, the popliteal artery; and in six patients, the iliac artery. The length of occlusion ranged from 5 to 35 cm (mean, 12.5 cm). The duration, estimated by history, was 5-48 months (mean, 16.5 months). In seven patients, durations of 6-36 months were documented angiographically. A flexible, blunt, motor-driven rotating catheter was introduced through an 8-F sheath, and rotational angioplasty was performed at low speed (up to 200 rpm). In 49 of 60 (82%) patients in whom this new technique was used as the primary intervention, the occlusions were successfully reopened. In 23 patients in whom conventional methods had failed more than 4 weeks earlier, the success rate for rotational angioplasty was 67% (12 of 18 patients); when the time interval was less than 4 weeks, only one of five patients was treated successfully. In none of the 83 patients did a perforation occur. This new technique can reopen chronic artery occlusions with a high degree of success and without the danger of vessel-wall perforation, even after failure of conventional techniques.

Adult↗
PubMed1989

Doppler ophthalmic blood pressure measurement in the hemodynamic evaluation of occlusive carotid artery disease.

In 102 patients with angiographically proven occlusive carotid artery disease of 60-100% diameter reduction, Doppler ophthalmic artery pressure and blood flow direction were recorded by the recently developed ophthalmomanometry-Doppler technique. Among these 102 patients, 50 presented with complete carotid artery occlusions and 52 with carotid artery diameter stenoses of greater than or equal to 60%. Mean +/- SD Doppler ophthalmic artery pressure was 69 +/- 15 mm Hg ipsilateral to the occlusion and 86 +/- 18 mm Hg ipsilateral to a stenosis of the carotid artery (p less than 0.001). The mean +/- SD Doppler ophthalmic pressure index (ratio of the ophthalmic artery to systemic blood pressure) was lower ipsilateral to the occlusion (0.46 +/- 0.08) than ipsilateral to a carotid artery stenosis (0.54 +/- 0.08; p less than 0.001); in both, the index was clearly diminished compared with normal values (0.68 +/- 0.04; p less than 0.001). It is concluded that the intracranial hemodynamic consequences in the patients with occlusion are on average more profound than in the patients with stenosis. In carotid artery occlusions, the mean +/- SD ipsilateral ophthalmic pressure index was 0.46 +/- 0.06 for antegrade and 0.46 +/- 0.09 for retrograde ophthalmic artery blood flow. In carotid artery stenoses, the mean +/- SD ipsilateral ophthalmic pressure index was 0.55 +/- 0.07 for antegrade and 0.48 +/- 0.06 for retrograde ophthalmic artery blood flow (p less than 0.01). These results indicate that in carotid stenoses the collateral capacity of the ophthalmic artery is insufficient compared with intracranial collaterals, while in carotid occlusions the blood flow direction in the ophthalmic artery does not predict intracranial hemodynamic compensation.

Adult↗
PubMed1989

[Rotation angioplasty--clinical experiences in 83 patients with chronic arterial vascular occlusion].

Chronic, total vascular occlusion represents the limit for use of balloon dilatation. Occlusions of the superficial femoral artery and popliteal artery of more than 10 cm in length have a low recanalization rate of 50 to 60% with conventional angioplasty. In iliac artery occlusions, in addition to a high rate of complications, the recanalization rate is only about 30 to 40%. Starting in 1984, we developed a slowly rotating (100 to 200 r.p.m.), electrically-driven, flexible catheter with a blunt tip, inside lumen and outer diameter of 2.2 mm for the purpose of recanalization (Figure 1). The theoretical basis was that such a catheter would seek the soft occluding thrombus as the path of least resistance. Since 1986, the procedure has been carried out in 56 patients with occlusion of the superficial femoral artery, 21 with occlusion of the popliteal artery and six with occlusion of the iliac artery. The duration of occlusion ranged between five and 48 months and the length of the occlusions between 5 and 35 cm (mean 12.5 cm); the patients were in Fontaine stage II and IV, the ankle arm-index ranged between 0 and 0.86 (mean 0,51). After antegrade or retrograde puncture of the common femoral artery and intra-arterial injection of 5,000 units of heparin, the rotation catheter was advanced through an 8F sheath through the occlusion by means of slow rotation (Figure 2). After contrast medium injection to document the intraluminal position of the catheter and the catheter exchange over a 0.35'' wire, the channel created was dilated.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1989

[Duplex ultrasound studies of the deep femoral artery].

In case of occlusion of the superficial femoral artery (SFA), the deep femoral artery (DFA) supplies the entire lower extremity. Not infrequently, the SFA occlusion is associated with stenosis of the origin of the DFA. The angiographic study of the origin of DFA is often unsatisfactory. The purpose of the present study was to develop objective criteria for the diagnosis of the DFA origin stenosis by duplex scanning. In 60 patients, we examined 75 femoral bifurcations by duplex scanning and compared them with the independently performed angiography. Group 1 (n = 20 DFA origins) consisted of 10 normal individuals. Group 2 (n = 30 DFA origins) consisted of 25 patients with angiographically proven SFA occlusion and normal DFA. Group 3 (n = 25 DFA origins) consisted of 25 patients with angiographically proven SFA occlusion and DFA orifice stenosis. We measured the maximal systolic and mean flow velocity in the orifice of the DFA at rest and during the maximal hyperemia following 3 min of ischemia of the lower leg. At rest, the maximal flow velocity in groups 1-3 was 60 +/- 15, 142 +/- 44, and 255 +/- 60 cm/s (p less than 0.01) and the mean flow velocity was 8 +/- 6, 32 +/- 9, and 96 +/- 42 cm/s (p less than 0.01). During hyperemia, the maximal and mean flow velocity for groups 1-3 was 59 +/- 15, 155 +/- 42, and 286 +/- 82 cm/s (p less than 0.01) and 8 +/- 5, 55 +/- 19, and 144 +/- 51 cm/s (p less than 0.01), respectively. An origin stenosis of the DFA is highly probable when at rest the mean and maximal velocity in the proximal DFA exceed 50 cm/s and 180 cm/s, respectively. These results show that duplex scanning is able to detect safely DFA origin stenosis. The increase in postischemic DFA flow velocity when SFA occlusion is present, helps to evaluate total flow resistance of the deep-outflow channels (run-off) thereby being useful in planning appropriate therapy.

Adult↗
PubMed1988

Results of low speed rotational angioplasty for chronic peripheral occlusions.

After experimental investigation using postmortem human arteries, 19 patients with chronic peripheral artery occlusions were treated with a new angioplasty technique between December 1986 and October 1987. In 17 patients the superficial femoral artery and in 2 patients the popliteal artery were completely occluded. The length of the occlusions ranged between 5 and 25 cm (mean 11). The duration--estimated according to patients' history--was 5 to 48 months (mean 17). In 5 patients, durations of up to 30 months had been documented by angiography. A flexible, blunt, motor-driven rotating catheter was introduced through an 8 or 9Fr sheath and rotational angioplasty was performed at low speeds (up to 200 rpm). In 11 of 14 patients in whom this new technique was used as the primary intervention, the occlusions could be successfully reopened. In 2 patients after failure of conventional techniques the rotating catheter could not bypass the preexisting dissections in the same intervention. In 2 of 3 further patients after failure of conventional techniques the occlusions could be successfully reopened in a second intervention after several weeks. In none of the 19 patients did a perforation occur. It is concluded that with the new technique chronic peripheral artery occlusions can be reopened with a high success rate and without the danger of arterial wall perforation. The method can also be used in patients in whom conventional techniques have failed.

Adult↗
PubMed1988

Femoro-popliteal artery thrombolysis with intra-arterial infusion of recombinant tissue-type plasminogen activator--report of a pilot trial.

Recombinant tissue-type plasminogen activator (rt-PA) was infused at a rate of 10 mg/h into 50 thrombosed femoral and popliteal arteries. Patency was restored in 43 but a secondary angioplasty led to 2 reocclusions and in 3 patients early rethrombosis occurred. A favourable clinical result was thus obtained in 38 patients (76%). Thirteen bleeding complications occurred in 10 patients, mainly haematomas at puncture sites. One patient required blood transfusion for gastro-intestinal bleeding from a previously unknown ulcer. The angiographic recanalisation rate in 16 patients who received a slower infusion of rt-PA (5 or 3 mg/h) was 94% and the clinical success rate in this series was 81%. However, the incidence of bleeding complications was not decreased by the slower infusion rate. The data obtained confirm the feasibility of rt-PA thrombolysis in peripheral arterial thrombosis and warrant a comparative study with streptokinase.

Angioplasty, Balloon↗