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Biomedical subjects

F J Viozzi

Publications and source records attributed to F J Viozzi.

6 recordsLinked to original sources

Sarcoid arthritis in a North American Caucasian population.

Thirty-two of 150 Caucasian patients (21%) with sarcoidosis studied had articular symptoms. Twenty-one had acute sarcoid arthritis with bilateral ankle arthritis/periarthritis. Joint symptoms resolved within 4 months and none developed chronic arthropathy or progressive systemic sarcoidosis. Eleven patients developed articular involvement during the course of chronic pulmonary sarcoidosis manifested by bilateral hilar adenopathy in 8 and parenchymal disease in 9. Joint symptoms were generally transient, however, persistent synovitis in excess of one year was seen in 2 patients. Acute sarcoid arthritis confers a favorable prognosis in North American Caucasians. Differences from previous American series likely reflects the racial compositions of the population studied. Sarcoid arthritis less often evolves during the course of chronic systemic sarcoidosis and even then rarely progresses to a chronic arthropathy.

Adult↗

Clostridium perfringens: an unusual case of septic arthritis.

Anaerobic joint infections may be a more common occurrence than previously reported. A nine-year-old with a septic knee due to Clostridium perfringens following a puncture wound was seen in the emergency department. Diagnosis was established by isolating the organism from an anaerobic synovial fluid culture. The patient was treated successfully with open drainage and parenteral penicillin. This case illustrates the necessity for specifically requesting anaerobic cultures on synovial fluid of patients with acute septic monoarthritis.

Arthritis, Infectious↗

A dissecting popliteal cyst presenting as acute thrombophlebitis.

A patient with psoriatic arthritis presented to the Geisinger Medical Center emergency department after the sudden onset of pain and swelling in his left calf. Initially, the patient was thought to have acute thrombophelebitis. Upon further examination, the diagnosis of a ruptured popliteal cyst was considered, and was confirmed with arthrography. The case illustrates an occurrence of a dissecting popliteal cyst simulating an cute deep vein thrombosis in a patient with an inflammatory process involving the knee.

Adult↗

Nemaline myopathy.

Nemaline myopathy occurred sporadically in a 59-year-old woman. She had slowly progressive weakness. A muscle biopsy specimen showed nemaline rods, increased variation in fiber size, apparent loss of Type IIb fiber differentiation, and a "moth-eaten" pattern of the intermyofibrillar network. At least 44 cases of this disorder have been reported. Clinically, they showed several different modes of onset, patterns of muscle group involvement, and rates of progression. There was a suggestion of familial involvement in at least half. In addition to the presence of nemaline rods, pathological abnormalities of muscle biopsy specimens were quite variable. Results of recent biochemical studies have shown abnormal myosin in a patient with rod myopathy. A hypothesis is proposed that relates the diverse clinical and histological features of this disease to a hereditary molecular abnormality of myosin synthesis.

Female↗

The musculoskeletal manifestations of acne fulminans.

We describe a relatively uncommon and poorly understood relationship between a particularly severe form of acne and an associated arthritis. Two young men are described, 1 of whom possesses the HLA-B27 antigen. Their clinical courses are described, responses to therapeutic intervention outlined, and some speculation regarding etiology is made. A review of the literature is included. The prognosis is uncertain, since 1 of the patients has sacroiliitis.

Acne Vulgaris↗