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Biomedical subjects

F János

Publications and source records attributed to F János.

6 recordsLinked to original sources
PubMed1988

Effects of lentinan on cytotoxic functions of human lymphocytes.

The in vitro effects of lentinan on natural killer (NK), antibody-dependent cell-mediated cytotoxicity (ADCC), lectin-dependent cell-mediated cytotoxicity (LDCC) and mitogen-induced blast transformation were studied in patients with solid tumors and chronic lymphocytic leukemia (CLL). NK activity was measured against 51Cr-labelled K-562 targets, ADCC against antibody-coated chicken red cells. LDCC and natural cell-mediated cytotoxicity (NCMC) was assessed using 3H-thymidine prelabelled HEp-2 targets. Mitogen (PHA- and Con A-) induced blast transformation was measured by thymidine incorporation. Blastogenesis and LDCC was not influenced by lentinan. 1 microgram/ml lentinan increased NCMC of tumor-bearing subjects. The most prominent enhancement of NK and ADCC activity was seen in CLL patients, where a dose-related increase was seen (from 0.01 to 1 microgram/ml).

Antibody-Dependent Cell Cytotoxicity↗
PubMed1976

[Synaptic lamellae in retinoblastoma].

Out of 27 cases of differentiated and notdifferentiated types of retinoblastoma synaptical lamelles surrounded by synaptical vesicula could be detected in 8 cases. They were observed partly in different areas of the cytoplasma, partly in projections of cells. These structures seem to evidence the neurogen origin of the retinoblastoma.

Eye↗
PubMed1976

[Open fractures of the hand joints].

In the authors' opinion the optimal treatment of the open fractures of the hand articulations is the internal fixation offering the best fixation possible--this being the best antidote of the inflammatory complications and assuring the satisfactory late functional results. The splinting (stabliizing) methods known so far--as well as the preventive measures applied by the authors against inflammatory complications are discussed.

Fracture Fixation, Internal↗