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Biomedical subjects

F Jaggi

Publications and source records attributed to F Jaggi.

6 recordsLinked to original sources
PubMed2000

[Pulmonary aspergillosis complicating chronic septic granulomatosis. Treatment with itraconazole and gamma interferon].

A 20-year-old patient suffering from chronic granulomatous disease developed pulmonary aspergillosis with thoracic wall invasion. Treatment with itraconazole combined with 3-weekly injections of interferon gamma (INF gamma) improved the patient's general state of health within two months. Functional signs resolved totally and x-ray images continued to improve for 6 months. INF gamma was withdrawn after 11 months and was replaced with cotrimoxasole. Itraconazole was continued in a long-term regimen. Four years after onset of treatment, the clinical status of the patient remained satisfactory, and the radiological aspect was unchanged. Pulmonary aspergillosis affects up to 40% of patients suffering from chronic granulomatous disease. Mortality is high, to the order of 25%. The classical treatment is based on amphotericin B, but this case points out the significant contribution of itraconazole as first-line therapy. This antimycotic has been suggested for prophylaxis. The combined use of INF gamma can be discussed due to the uncertainties about its long-term effects and because of the requirement for 3-weekly injections. High cost is another important consideration.

Adult↗
PubMed1993

[The first successful lung resection].

In 1883 Krönlein resected a sarcoma of the ribs in an 18 year old female. Six months later he reoperated the patient for a local recurrency. At the second operation which necessitated a wide exposure of the thoracic cavity he deliberately removed a pulmonary metastasis about the size of a walnut. Two years later a new recurrence had to be resected. The three interventions led to a survival of 7 years. The patient succumbed to a further recurrence in 1890. Krönleins operation opened two new chapters in surgery, pulmonary interventions in general and in particular surgery of pulmonary metastasis. Surgery of lungs was not a topic of that era, particularly since some incisions for abscesses and resections of pulmonary parenchyma had not been successful. By limiting the indication to patients with sufficient pulmonary function and by following the successful pneumonectomy experiments in animals Krönlein favored pulmonary resection. The success of this intervention confirmed these considerations especially since it lasted for years. It was followed in 1885 by a pulmonary resection by G. Ruggi in Bologna. Surgery of the lung, however, came in general use only 50 years later.

Germany↗
PubMed1993

[Thoracopagus symmetricus. On the separation of Siamese twins in the 10th century A. D. by Byzantine physicians].

The byzantine author, Leon Diakonos, mentions in 974/975 A.D. a pair of "siamese twins", e.g., a thoracopagus symmetricus. He had seen them personally several times in Asia Minor when they were about 30 years old. This pair is possibly the same that was "successfully" surgically separated after the death of one of the twins in the second half of the 10th century in Constantinople. This operation is mentioned by two historiographs, Leon Grammatikos and Theodoros Daphnopates. Although the second twin survived the operation, he died three days later. In spite of its lethal outcome, the operation left a long-lasting impression on the historians of that time and was even mentioned 150 years later by Johannes Skylitzes. Furthermore, the manuscript of Skylitzes, now in the library of Madrid, contains a miniature illuminating this operation. This is likely to be the earliest written report of a separation of siamese twins illustrating the high standard of byzantine medicine of that time.

Adult↗
PubMed1990

[Long-term results of surgical treatment of lung metastases].

A retrospective review covered 110 patients who had had 130 thoracotomies for 193 lung metastases between 1960 and 1988. The cumulative survival rate after 5 years was 39%, 24% after 10 years and 13% after 15 years. The median survival was 3.8 years; the average survival was 7 years. In a multivariate analysis, response to prior chemotherapy, local tumor extent (intrapulmonary versus extrapulmonary disease) and venous drainage (caval versus portal) were the most important prognostic factors. The number of metastases and the interval between primary tumor and lung metastases were of minor prognostic importance.

Adolescent↗
PubMed1990

[5 and 10 years results of surgical treatment of lung metastases].

This is a report on 105 patients who had 125 thoracotomies for 188 lung metastases between 1960 and 1987. The cumulative survival rate at 5 years was 39% and 24% at 10 years and 13% at 15 years. The median survival is 3.7 years, the average survival is 7 years due to prolonged follow-up. With combined modality therapy, testicular and uterine cancers yielded the best survival results with a 5-year survival rate of 100% and 67%, respectively. In multi-variate analysis, response to prior chemotherapy, local tumor extent (intrapulmonary versus extrapulmonary disease) and venous drainage (caval type versus portal type) were the most important prognostic factors whereas the number of metastases and the interval between primary tumor and lung metastases were of minor prognostic importance. The present results are compared with long-term results of other centres and emphasize the importance of resection in combined modality therapy concepts of lung metastases.

Adolescent↗