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Biomedical subjects

F Jeannot

Publications and source records attributed to F Jeannot.

6 recordsLinked to original sources
PubMed1980

[Has haemofiltration a specific therapeutic effect? A co-operative study involving 20 patients (author's transl)].

In order to evaluate the effects of haemofiltration (HF) on blood pressure control, hyperparathyroidism and hypertriglyceridaemia, the relevant clinical and biological parameters were compared under haemodialysis (HD) and under haemofiltration using a substitution fluid (SF) acetate. Blood pressure control was achieved with HF in only one of 14 hypertensive patients. In 17 patients, with the same doses of Al (OH)3, plasma phosphate levels were similar under HD (63 mg/l) and HF (67 mg/l). In 3 patients, measurements of plasma parathyroid hormone (PTH) levels in the presence of increasing concentrations of SF calcium showed that a concentration of 90 mg/l was required to obtain a positive calcium balance and a decrease in PTH levels. After 6 months, PTH levels under HD and under HF were comparable. In 20 patients, there were no significant differences between HD and HF in mean plasma concentration values of total lipids, cholesterol and triglycerides. Finally, HF was better tolerated than HD in 58% of the cases and less well tolerated in 8%.

Blood↗
PubMed1977

[Is it possible to treat uremia by hemofiltration? Initial clinical results obtained with a poly-acrylo-nytril membrane].

Following to work of Quellhorst, the authors used an RP6 haemodialyser as an ultrafilter and exchanged 20 litres of plasma ultrafiltrate against 18 to 20 litres of physiological solution during 200 sessions of 4 to 5 hours in 5 patients with uraemia, over a period of 3 to 10 months. The technique is simple and tolerance excellent. The possibility of a new approach to the treatment of uraemia without dialysate makes a large clinical trial worthwhile.

Acrylonitrile↗
PubMedDate not supplied

Synthesis and antiviral evaluation of 3'-C-trifluoromethyl nucleoside derivatives bearing adenine as the base.

3'-deoxy-3'-C-trifluoromethyl- (3), 2',3'-dideoxy-3'-C-trifluoromethyl- (5) and 2',3'-dideoxy-2',3'-didehydro-3'-C-trifluoromethyladenosine (6) derivatives have been synthesized and their antiviral properties examined. All these derivatives were stereospecifically prepared by glycosylation of adenine with a trifluoromethyl sugar precursor (1), followed by appropriate chemical modifications. The prepared compounds were tested for their activity against HIV, but they did not show an antiviral effect.

Anti-HIV Agents↗