Platelet reactions and immune processes. VI. The effect of immunoglobulins and other plasma proteins on platelet surface interactions.
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Biomedical subjects
Publications and source records attributed to F Jobin.
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1. A technique for the isolation of factor V from bovine plasma is described. 2. Some of the physicochemical properties of the protein have been measured and the amino acid composition has been determined.
1. It has been shown that factor V accelerates the rate of conversion of prothrombin into thrombin by activated factor X, and that this activity does not depend on the presence of phospholipid. 2. Although the mechanism by which factor V increases the rate of reaction is not clear, it seems unlikely that it is converted into an enzyme. 3. The rate of conversion of prothrombin by purified activated factor X and factor V was increased threefold in the presence of phospholipid, and it is suggested that the lipid acts by adsorbing the proteins on its surface and hence increasing the local concentration of the reactants.
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