[Motility and body temperature of mice in various temperatures].
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Adaptation, Physiological↗
Biomedical subjects
F K Ohnesorge
Publications and source records attributed to F K Ohnesorge.
[The oxygen consumption of mice in various ambient temperatures].
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Animals↗
Glutathione peroxidase and glutathione S-transferase activity of platelets.
A low Se intake in dietetically treated patients with phenylketonuria (PKU) or maple syrup urine disease (MSUD) leads to a marked reduction of the platelet glutathione peroxidase activity (GSHPx). The mean value amounted to 2.0 U/10(11) platelets with t-butyl hydroperoxidase (t-BOOH) (2.2 U/10(11) with H2O2) in patients and 5.8 U/10(11) with t-BOOH (5.4 U/10(11) with H2O2) in the control children. After Se supplementation with yeast rich in Se (dose: 135 micrograms Se/m2) the GSHPx activities rapidly increased. They reached a plateau after 2-3 weeks and remained there during the following 15-20 weeks of supplementation. After the cessation of supplementation there was a slow decrease, the values reached a low plateau after 24 weeks. In addition platelet glutathione S-transferase (GSHTf) was estimated with 1-chloro-2,4-dinitrobenzene. No significant difference between the values in healthy and dietetically treated patients in a low or normal Se state was observed. GSHTf did not exhibit peroxidase activity and did not show a compensatory increase when Se dependent GSHPx activity was low. The patients do not reveal clinical signs of disturbed platelet function. GSHPx may act in platelets via lipoxygenase on the prostaglandin pathway. The physiologic consequence of altered arachidonate metabolism, when GSHPx is deficient in platelets, remains to be elucidated.
Blood Platelets↗
Renal aluminum excretion.
Urinary aluminum (Al) excretion was studied in humans with normal and impaired renal function. Al was measured by atomic absorption spectrometry. In healthy volunteers (n = 50), renal Al excretion was 12.2 +/- 8.5 micrograms/24 h. Two patients on plasma exchange therapy with normal renal function and an inadvertent load of 870 and 388 micrograms Al/treatment showed a 23 and 14% positive balance until next treatment. The renal pathway of excretion was shown to be important in 6 chronic renal failure patients on continuous peritoneal dialysis with residual renal function who eliminated in 24 h 51.4 +/- 24.0 micrograms Al by urine and only 27.2 +/- 18.4 micrograms Al across the peritoneum following a daily oral application of 342 mg Al. Studies with the isolated perfused rat kidney confirmed the limited renal capacity to eliminate Al. Al clearance declined from 0.75 to less than 0.08 mL/min when the kidney was perfused with 0.04-12.4 micrograms Al/mL medium. Al content of the kidney increased in a dose-dependent manner from less than 0.05 to 4.4 micrograms/kidney and reached saturation at 5 micrograms Al/mL medium.
Adult↗
Uptake of aluminum, cadmium, copper, lead, and zinc by human scalp hair and elution of the adsorbed metals.
Uptake of aluminum (Al), cadmium (Cd), copper (Cu), lead (Pb), and zinc (Zn) from aqueous solutions by human scalp hair (water/hair = 100:1) has been studied in the concentration range 0-50 mg/L. Hair metal levels were determined by a wet digestion procedure and atomic absorption spectrometry. Under conditions used, uptake followed a sigmoid concentration-response relationship. The order of binding capacity of hair to the metals was as follows: Al greater than Cd greater than Cu greater than Pb greater than Zn. Using logit transformation 50% saturation was evaluated at the following metal concentrations (hair metal concentration of saturation is given in parenthesis): 0.34 mg/L for Al (0.154 mg/g); 1.82 mg/L for Cd (0.363 mg/g); 2.21 mg/L for Cu (0.651 mg/g); 2.52 mg/L for Pb (0.986 mg/g); 23.84 mg/L for Zn (1.616 mg/g). Percentage elution of trace metals from hair after treatment with metal-enriched solutions by five different procedures ranged from 14.5 to 46.5% for Al, from 11.1 to 28.9% for Zn, from 11.5 to 28.4% for Pb, from 8.9 to 13.6% for Cd, and from 0.1 to 11.8% for Cu. In addition, trace element concentrations were measured in tap water samples and shampoos.
Acetone↗
Influence of storage conditions on aluminum concentrations in serum, dialysis fluid, urine, and tap water.
The influence of storage temperature, vessel type, and treatment on alterations of aluminum (Al) concentrations in serum, urine, and dialysis fluid samples was studied at three different concentrations for each sample over an 18-month period. Furthermore, the influence of acidification on Al levels in tap water, urine, and dialysis fluid samples was studied over a four-month period. Al was measured by atomic absorption spectrometry. Sample storage in glass vessels was unsuitable, whereas only minor alterations of Al levels were observed with storage in polypropylene tubes, polystyrene tubes, and Monovettes. By using appropriate plastic containers, acid washing of the vessels showed no improvement. Frozen storage was superior compared with 4 degrees C, whereas storage at -80 degrees C offered no advantage compared with storage at -20 degrees C. Acidification of tap water samples was necessary to stabilize Al levels during storage. No striking effect of acidification on Al levels in urine and dialysis fluid samples was found. It is concluded that longterm storage of serum, urine, tap water, and dialysis fluid samples is possible if appropriate conditions are used.
Aluminum↗