PubMed Health⌕ Search

Biomedical subjects

F K Pedersen

Publications and source records attributed to F K Pedersen.

At least 73 records · Page 4Linked to original sources
PubMed1982

Antibody response to pneumococcal vaccine in splenectomized adults and adolescents.

The antibody response of 67 splenectomized adults and adolescents with benign underlying diseases to a 14-valent pneumococcal capsular polysaccharide vaccine was determined by an enzyme-linked immunosorbent assay. It was not significantly different from that of 12 healthy non-splenectomized adult volunteers for 13 of the 14 polysaccharide antigens studied. Residual splenic tissue as detected by Tc-scintigraphy was without any influence on the vaccination response. In comparison 5 untreated splenectomized adults with malignant diseases and 11 splenectomized adults receiving immunosuppressive therapy exhibited a significantly reduced combined geometric mean of their postvaccination antibody concentrations (all 14 antigens added) and of their combined geometric mean antibody fold increase as compared to the healthy non-splenectomized adults. The reduction in antibody response was most pronounced in the group of immunosuppressed patients. Immunogenicity of each of the 14 vaccine antigens varied considerably as judged by the geometric means of the postvaccination arbitrary antibody concentrations. Also individual variation in postvaccination antibody concentration against each antigen was large.

Adolescent↗
PubMed1982

Antibody response and opsonization afer pneumococcal vaccination in splenectomized children and healthy persons.

A significant rise in antibody against pneumococcal types 3, 6A and 25 after pneumococcal vaccination could be demonstrated in 26 of 30 individuals (87%) using an enzyme-linked immunosorbent assay. Similar geometric mean antibody fold increases were found in splenectomized children, non-splenectomized children and healthy adults for types 6A and 25. Splenectomized children exhibited a somewhat lower, but not statistically significant, geometric mean antibody fold increase against type 3 (p = 0.10), as compared to non-splenectomized children. For the whole group a negative correlation could be demonstrated between prevaccination antibody concentration and antibody fold increase after vaccination. After vaccination an enhanced serum opsonic activity against type 3 was found by granulocyte glucose-l-14C oxidation for the whole group of 30 patients (p less than 0.05) but nine individual patients (30%) failed to exhibit an increase. No differences between the three patient groups were demonstrable. Changes in serum opsonic activity could not be detected by a pneumococcal bactericidal assay.

Adolescent↗
PubMed1982

Anti-C-carbohydrate antibodies after pneumococcal vaccination.

Similar levels of naturally occurring anti-pneumococcal C-carbohydrate antibodies were found in 15 splenectomized children, 10 splenectomized adults and 12 healthy adult volunteers by enzymelinked immunosorbent assay. Vaccination with a 14-valent pneumococcal capsular polysaccharide vaccine (Pneumovax) that contains approximately 75 micrograms C-carbohydrate per dose only led to small anti-C-carbohydrate antibody increases; they were significant, however, for all three groups (p less than 0.05) but antibody fold increases were below 2 in 34 of the 37 individuals studied.

Adolescent↗
PubMed1982

Detection of antibodies to pneumococcal capsular polysaccharides by enzyme-linked immunosorbent assay.

An enzyme-linked immunosorbent assay for the detection of immunoglobulin G, M, and A antibodies against each of the 14 polysaccharide antigens contained in a contemporary pneumococcal vaccine is described. A mean total antibody fold increase above 2 from prevaccination to 4 weeks postvaccination serum samples was found for all antigens in 12 healthy adults and 6 children. Fifty-five percent of all single fold increases determined were above 2 in the adults; the value was 64% in children. Type-specific polysaccharide antibody of the immunoglobulin G class was predominant in 4 weeks postvaccination serum samples. Further studies with assays such as the one described may lead to a better understanding of the immune response to pneumococcal polysaccharides in both normal subjects and patients at increased risk of pneumococcal infection.

Animals↗
PubMed1981

Lymphocyte stimulation by gangliosides, cerebrosides and basic protein in juvenile rheumatoid arthritis.

Peripheral blood lymphocytes from patients with juvenile rheumatoid arthritis (JRA), patients with neurological diseases (ND) and healthy children were tested for reactivity to gangliosides, cerebrosides and basic protein (BP) by the active E-rosette test (AER). None of the lymphocytes from ND patients, healthy children or two children with psoriatic arthritis responded by increased rosette formation to gangliosides, cerebrosides and BP. Lymphocytes from all 16 children with JRA were sensitized to at least one antigen as shown by the AER test. The percentage of active T-cells was significantly lower (p less than or equal to 0.05)( in children with JRA as compared to others. The significance of the results in relation to immunopathogenesis of JRA is discussed.

Adolescent↗
PubMed1980

Granulocyte function in children with acute lymphoblastic leukaemia during remission.

The granulocyte function of 20 children with acute lymphoblastic leukaemia was studied during remission and compared to that of 20 health adults. Granulocyte function was equally decreased when examined in patient serum and pooled normal serum, The decreased bactericidal function was predominantly due to reduced intracellular killing. Patients with grossly reduced granulocytic function had more infections than the rest of the group, though the difference was not statistically significant.

Adolescent↗
PubMed1980

Severe combined immunodeficiency associated with hyperimmunoglobulinaemia E, eosinophilia and impaired neutrophil chemotaxis.

A boy with severe combined immunodeficiency was found to have coexistent hyperimmunoglobulinaemia E, eosinophilia and impaired neutrophil chemotaxis. Based on the literature, a deficient regulatory function of the T-cell system is proposed as the basic defect leading to the observed impairment of the cellular and humoral immunity and, probably through hyper-immunoglobulinaemia E, to defective neutrophil chemotaxis.

Chemotaxis, Leukocyte↗
PubMed1979

Refractory Pneumocystis carinii infection in chronic granulomatous disease: successful treatment with granulocytes.

Pneumocystis carinii pneumonia developed in an 11-year-old girl with chronic granulomatous disease who had normal cellular and humoral immunity. The patient remained febrile during treatment with sulfamethoxazole-trimethoprim and pentamidine but became afebrile when treated with a series of 12 granulocyte transfusions combined with sulfamethoxazole-trimethoprim. In addition to documenting P carinii infection in chronic granulomatous disease our findings suggest that granulocyte transfusions may be of value in the treatment of severe infections in chronic granulomatous disease.

Blood Transfusion↗
PubMed1978

Immunosuppressive measles encephalopathy.

A case of measles infection without a rash, which was followed by a severe encephalopathy after two months, is described in a 2 1/2 year old boy. At the age of 8 months he had been irradiated for an inoperable intrathoracic neuroblastoma, and at the time of exposure to measles he was being treated with cyclophosphamide and vincristine. This case closely resembles other cases recently described and termed immunosuppressive measles encephalopathy. The syndrome is believed to represent the effect of measles virus in patients with deficient cellular immunity induced by antineoplastic treatment. The importance of protecting children on immunosuppressive treatment for contracting measles is stressed.

Child, Preschool↗
PubMed1978

Fatal BCG infection in an immunocompetent girl.

A 6-year-old girl developed progressive symptoms of increased intracranial pressure starting 5 months after BCG vaccination. Thirteen months later craniotomy revealed an epithelioid cell granuloma of the arachnoid occluding the foramen of Magendie. No tubercle bacilli were found on histological examination. Insertion of a Pudenz shunt relieved the symptoms. Six months later generalized BCG infection developed, and in spite of treatment with ethambutol, rifampicin and isoniazid for 10 weeks, death occurred during an episode of increased intracranial pressure. Mycobacterium BCG could be cultured from several organs. The patient showed no obvious evidence of immuno-deficiency as judged on the basis of previous disease history, particle concentration of granulocytes, B and T lymphocytes in peripheral blood, concentration of immunoglobulins in serum, response of lymphocytes to transformation with mitogens and antigens, and histological findings in the thymus and BCG granulomas.

BCG Vaccine↗
PubMed1977

Indication of primary immune deficiency in Fanconi's anemia.

A girl with various congenital malformations developed pancytopenia and hypoplastic bone marrow at the age of 6 year. A chromosome study of lymphocytes showed numerous breaks, gaps and rearrangements, allowing the diagnosis of Fanconi's anemia. Treatment with corticosteroids and splenectomy did not result in hematologic remission. Repeated immunologic studies showed increasingly deficient T cell function as judged by lymphocyte transformation studies and skin test reactivity, whereas T cell number, T/B cell ratio, immunoglobulins, complement factors and neutrophil function were normal. A sever Pneumocystis carinii pneumonitis developed, but was successfully treated with pentamidine, sulfametoxazole with trimetoprim and transfer factor. Improvement of T cell function followed transfer factor therapy. Combined therapy with corticosteroids and androgens caused partial remission of the hematologic abnormalities. The probability of a primary immune deficiency in the patient is discussed.

Abnormalities, Multiple↗
PubMed1976

Bacterial endocarditis at Blegdamshospitalet in Copenhagen 1944-1973.

The clinical pattern of 34 cases ob subacute bacterial endocarditis (SBE) and 46 cases of acute bacterial endocarditis (ABE) is outlined. In the SBE group the mortality was 9% and the incidence of major complications during the treatment period was 15% for cerebrovascular accidents, 9% for other systemic or pulmonary emboli and 9% for congestive heart failure indicating valvular damage. In 31 bacteriologically proven cases growth was obtained in 68% of all blood cultures, and in 94% of the cases at least one positive culture was among the first 5 ones drawn. In the ABE group the overall mortality was 72% and mortality for cases occurring after 1960 was 58%. Major factors contributing to death were valvular incompetence, uncontrolled infection and embolisation. In order to reduce major complications and resulting disability in SBE it is suggested that treatment be started on clinical suspicion as soon as 5 blood cultures have been drawn over a period of 48 hours. Attempts to reduce mortality in ABE may include cardiac surgery in the acute phase.

Acute Disease↗