Early observations about the ABO blood groups.
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Biomedical subjects
Publications and source records attributed to F K Widmann.
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Potential transfusion reactions include hemolysis, disease transmission (particularly hepatitis), allergic and febrile reactions, and symptoms of circulatory overload. Limiting the number of transfusions given to patients for whom the procedure will achieve some clearly defined clinical goal is one way of reducing the number of adverse reactions. When transfusion is to be carried out, great care should be taken in correctly identifying both patient and blood to avoid ABO mix-ups, and thorough pretransfusion laboratory testing should be done. During and after transfusion the patient should be closely observed for complications.
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Single-donor cryoprecipitate is the most convenient and reliable source of fibrinogen. A change by the regional Red Cross Blood Service to the production of low-volume cryoprecipitate led the authors to reexamine the fibrinogen content of cryoprecipitate units. The average fibrinogen content of individual low-volume (4 ml) units (n = 23) was 101 +/- 48 mg; in the 10-unit pools (n = 9 pools), content was 89 +/- 13 mg. Both measurements were considerably lower than previously published. By contrast, the mean fibrinogen content of regular-volume (15 ml) cryoprecipitate units (n = 8) was 142 +/- 50 mg. The fibrinogen was stable for at least 4 hours after thawing, and it survived refreezing and thawing.
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