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Biomedical subjects

F König

Publications and source records attributed to F König.

7 recordsLinked to original sources
PubMed1992

Influence of different methods of vagotomies on the secretion of cholecystokinin in dogs.

In six dogs, a selective proximal vagotomy, gastric vagotomy, and truncal vagotomy were performed successively. Basal and postprandial cholecystokinin (CCK) concentrations in the peripheral blood were measured by radioimmunoassay. After all the different types of vagotomy, especially after truncal vagotomy, an increased postprandial secretion of CCK was found compared with the healthy animal. Possible causes discussed are the cutting of vagal fibers, which might inhibit the secretion of CCK cells, and the changed gastric and pancreatic secretion.

Animals↗
PubMed1991

Reversible decrease of oxygen consumption by hyperoxia.

The hemodynamic and metabolic effects of 90 minutes normobaric hyperoxia were studied in 20 critically ill patients (11 septic, 9 nonseptic) requiring mechanical ventilation with inspired O2 fraction (FIO2) less than 0.40. Thirty minutes after increasing the FIO2 to 1.0, arterial PO2 had increased from about 100 to about 400 mm Hg, and whole body oxygen uptake (VO2) was decreased 10 percent (p less than 0.05) due to an 18 percent decrease in O2 extraction ratio. During the subsequent 60 minutes of hyperoxia, there was no further significant change in VO2. Cardiac index did not change in hyperoxia, but it increased 10 percent (p less than 0.05) in recovery as systemic vascular resistance decreased. VO2 returned to baseline after 30 minutes recovery at original FIO2 due to increased O2 extraction as well as the increased cardiac output. The decrease in VO2 without a decrease in O2 delivery may reflect maldistribution of blood flow and functional O2 shunting to protect tissue from unphysiologically high PO2. While brief oxygenation is advisable before periods of hypoventilation, the present data suggest that hyperoxic ventilation in these patients with already adequate O2 delivery was counterproductive.

Bacterial Infections↗
PubMed1990

[Diagnosis and prevalence of latent hepatic encephalopathy].

To compare the efficacy of various psychometric and neurophysiological tests in the detection of latent hepatic encephalopathy (LHE) cerebral functions were studied in 146 patients with liver cirrhosis but without overt encephalopathy and in 146 matched controls. Patients with liver cirrhosis scored significantly worse than controls in 8 out of 11 tests. Best discrimination between patients with cirrhosis and controls was obtained by testing for reaction time to white and colored light with a reaction time apparatus (DTG), and with the digit symbol (UT1) and block design test (UT4), i.e. with two Wechsler adult intelligence scale performance tests. Thirtyseven out of 146 (25%) patients with cirrhosis reveiled an abnormal result with the DTG alone. A combination of the DTG, UT1 and UT4 yielded the diagnosis in 44 (30%) patients. LHE correlated with the severity of the disease (Child-Pugh classification) but not with its etiology or with portasystemic shunting. In the Federal Republic of Germany about 300,000 subjects suffer from liver cirrhosis. Based on our results 100,000 of them may have LHE.

Adult↗
PubMed1988

Lack of dose-rate effect for mutation induction by gamma-rays in human TK6 cells.

Survival and mutation induction in a human lymphoblastoid cell line ('TK6'), after acute X- and low dose rate continuous gamma-irradiation, were investigated using the hypoxanthine guanine phosphoribosyl transferase (HGPRT)- and the thymidine kinase (TK)-mutation assay. The surviving fraction after acute exposure decreased exponentially (D0 = 0.47 Gy). The HGPRT- and TK-mutation frequencies after acute X- and continuous gamma-irradiation (2.7 and 27 mGy/h) showed linear responses and no dose-rate dependence.

Cell Line↗
PubMed1985

[Development of a questionnaire for problem solving].

Presented is the development of a measuring instrument in order to assess the problem solving ability (PLF). The PLF consists of 5 scales: a) experiencing problems, b) problem denial, c) tendency to solve problems in an unconventional way, d) dealing with the problem and e) tendency to conservative problem solving. Test-theoretical analyses are reported as well as, in greater detail, studies for test validation on various populations. High covariations can be shown especially for personality factors.

Adaptation, Psychological↗