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Biomedical subjects

F Körner

Publications and source records attributed to F Körner.

At least 37 records · Page 2Linked to original sources
PubMed1992

[Systemic corticosteroid therapy in non-arteritic anterior ischemic optic neuropathy].

A non-arteritic anterior ischemic optic neuropathy has usually a poor prognosis. Spontaneous remissions are extremely rare. In contrast to arteritic anterior ischemic neuropathy, systemic corticosteroids are generally accepted to be ineffective. Two cases of bilateral severe non-arteritic anterior ischemic optic neuropathy are reported who underwent full remission of their visual function directly related to high-dose systemic corticosteroids. It is hypothesized that, in acute phases of non-arteritic anterior ischemic optic neuropathy a significant reduction of tissue swelling and consecutive prelaminar reperfusion can be achieved with high-dose corticosteroids.

Dose-Response Relationship, Drug↗
PubMed1992

[Perimetry findings before and after surgical removal of epimacular membranes].

The visual acuity and the central visual field (Octopus program M1) were analyzed before and after peeling of epimacular membranes (EMM) in 18 eyes. The EMM were classified according to their etiology as idiopathic, secondary nonvascular and secondary vascular. A large variability of initial visual field indices was found pre- and postoperatively (table 1). The least functional improvement was found following peeling of EMM with a history of more than 12 months as well as of idiopathic EMM with an initial mean defect (MD) of greater than 3 dB (fig. 8 und 9). The best success rate was achieved for eyes with idiopathic EMM and MD less than or equal to 3 dB and for eyes with secondary nonvascular EMM (fig. 6 and 7). The visual acuity but not the MD improved postoperatively in the 3 eyes with vascular EMM which had developed after a retinal vascular branch occlusion.

Aged↗
PubMed1992

[Chronic uveitis: course after vitrectomy].

Vitrectomy is an acknowledged method in the therapy of chronic uveitis and its complications. We analysed the functional results after vitrectomy of 106 patients (121 eyes). In more than 61% of the patients, the visual acuity improved more than one line. There is less glare, and stereoscopic vision is better. In 10% of the patients, the follow-up was complicated by a retinal detachment; in contrast, a primary retinal detachment was the indication for the vitrectomy in 19%. Our study shows that vitrectomy helps reducing the frequency of recurrence of uveitis and the intensity of drug therapy.

Chronic Disease↗
PubMed1992

[Vitrectomy in Terson syndrome. Report of 18 cases].

A vitrectomy was performed in 18 eyes (15 patients) with vitreous hemorrhages due to Terson's syndrome. The average age of the patients was 46.5 +/- 14.4 years. The mean interval between the acute event of an intracranial hemorrhage and the vitrectomy was 6.8 +/- 4.9 months. The vitreous hemorrhage was associated with epiretinal membranes in 3, PVR in 2, and retinal breaks and/or rhegmatogenous retinal detachment in 3 eyes. The vitrectomy had to be combined with membrane peeling in 2, encircling procedures or exoplants in 4, cryotherapy in 5, endolaser in 1, and air/SF6 gas filling in 3 eyes. A missing or incomplete posterior vitreous detachment in 8 eyes was associated with a higher risk of PVR and retinal detachment. Two eyes with this condition needed 3 secondary operations. The mean follow-up duration was 32 (1 to 126) months. Two patients died 4 and 11 months after the operation. The visual acuity improved significantly following vitrectomy in all 18 eyes. The final visual acuity was better than 20/40 in 73% and 20/25 to 20/20 in 56%. The initial postoperative visual acuity decreased later on due to nuclear cataract in 7 of 10 eyes of patients over 45 years of age. A complicated cataract developed in only 1 of 8 eyes of younger patients who maintained a mean visual acuity of 20/25. Vitrectomy for Terson's syndrome is recommended in bilateral cases without spontaneous clearing of the vitreous within 3 months, as well as in cases with PVR and imminent retinal detachment.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1992

[Prognosis of penetrating keratoplasty in secondary endothelial atrophy of diverse etiology].

Endothelial atrophy following cataract extraction is an increasingly important indication for perforating keratoplasty (PK). Other significant indications for PK are the treatment of endothelial atrophy following vitreous/retinal surgery for perforating injuries or primary retinal pathology. We evaluated the first year post-operative course of fourteen patients that underwent PK: 7 patients with silicon-oil induced keratopathy (group I), and 7 patients with endothelial atrophy following anterior segment surgical procedures (group II). On follow-up, group II exhibited a significant improvement of visual acuity. In group I, despite the clarity of the graft, there was no improvement of vision because of the development of retrocorneal membranes, or pre-existing or progressive retinal changes.

Aged↗
PubMed1991

[Value of the RPM safety index in retinopathy of prematurity].

The safety-index (S-index): S = log birth weight (kg) + gestational age (weeks)/oxygen therapy (days) combines the three main risk factors for a development of ROP. Only in very immature children which had a long time oxygen therapy (and therefore a low S-index) one finds severe stages of ROP. In our study, we correlated retrospectively ROP stages versus S-index in 261 children. The results confirm that children with S-index greater than 1 never had a severe ROP (that means, stage 3 and more, which need treatment). Therefore, the 2/3 of all newborn infants at risk with an S-index greater than 1 need only minimal ophthalmological controls.

Birth Weight↗
PubMed1990

[Diabetic retinopathy].

The risk of blindness in diabetes may be significantly reduced by a suitable ophthalmic therapy. In order to apply this therapy in due time to the population at risk, all diabetics should be referred to ophthalmological follow-up examination at regular intervals. A rapid progression of a retinopathy may occur in young patients, especially during puberty and pregnancy, after change from oral antidiabetics to insulin and, temporarily, following strict control of blood glucose. Besides normoglycemia, the prevention of a high blood pressure is an important prerequisite of an efficient treatment of diabetic retinopathy. Retinal photocoagulation has been proven the most effective mode of therapy. The correct indication and stage-depending dosage of retinal laser coagulation in diabetes is a demanding task which should be reserved to well-trained specialists in this field. Diabetic vitreous bleeding and retinal traction detachment are complications of advanced proliferative diabetic retinopathy, which can be treated successfully in 60-70% of the cases by modern techniques of vitreoretinal surgery.

Blood Glucose↗
PubMed1990

[Immunohistochemical differentiation of periretinal membranes].

The etiology of periretinal membranes, a complication of various ocular diseases, trauma, and ocular surgery, is still unknown. In the study reported here, 134 surgically removed periretinal membranes were semiquantitatively analyzed by immunohistochemical and morphological method (antigens S 100, GFAP, leukocyte antigens, factor 8; fibrosis). It was found that the cell population of the membranes varied both morphologically and immunohistochemically according to the disease. However, the RPE cell count did not correlate with the number of retinal tears recorded in the patients' histories.

Diabetic Retinopathy↗
PubMed1987

[Epidemiological study of severe vision impairment in Swiss children with special reference to retrolental fibroplasia].

On December 31 1984, 262 children between 7 and 16 years of age were being trained in the major institutions for the visually handicapped in Switzerland. Of these, 173 (66%) were visually impaired and 89 (34%) were blind (i.e. some or no light perception). The causes of the visual impairment were malformations (65%), infectious diseases (14%), retrolental fibroplasia (12%), metabolic disorders (4%), tumors (3%) and accidents (2%). Among the blind children these diagnostic groups were distributed as follows: malformations (53%), RLF (25%), infections (10%), tumors (10%). The rates of blindness within The single diagnostic groups were as follows: accidents: 4 out of 5 children; tumors: 78%; RLF: 69%. This risk of developing blindness in RLF children, as compared to the risk in the overall population studied, had the highest statistical significance (p less than 0.0001). Malformations (28%) and infectious diseases (22%) represented a lower than average risk of developing blindness, the average figure for the whole population being 34%. The risk of developing blindness as a consequence of infections was statistically not different from that in the total population investigated. All RLF children had a birthweight below 2000 g. By extrapolation an incidence of 0.24% RLF cases was estimated for prematures below 2000 g. During the 10 years under investigation (1968-1977), 3.6 new cases of RLF/100,000 live births were diagnosed per year, with a peak in 1975 and 1976. This figure is probably an underestimate, since severely brain damaged blind children with multiple handicaps were not considered.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1986

[Studies of the cell kinetics of human malignant testicular tumors].

The cellular DNA-content of 75 malignant testicular germ-cell tumours was determined by flow cytometry. The results are: Aneuploidy is a certain tumour marker in 95% of germ-cell tumours. The DNA-indices range from 2 c (diploid) to 6 c with a modal value around 3 c. 23% of germ-cell tumours are multiclonal. The S-phase percentage is higher than those of the most other solid tumours investigated so far and is 25.5% in seminomas and 35% in non-seminomatous germ-cell tumours. Further investigations of a greater number of tissues will show the importance of DNA-contents measurement by flow cytometry for the prognosis of testicular tumours, representing an addition to histopathology.

Aneuploidy↗
PubMed1986

[Retinopathy of prematurity].

The new international classification of the different stages of RLF is presented. The incidence of ROP varies between 10 and 80/100,000 live births, and 7 and 40% of all prematures. Recent data from Switzerland indicate that 12% of the 7-16 years old scholars in schools for visually disabled children have advanced stages of ROP (RLF). 27% of the totally blind scholars have RLF. The main risk factors are immaturity of retinal vascularization and oxygen. Other postulated risk factors like f.e. elevated or fluctuating pCO2 are discussed. Indications and a time schedule for ophthalmological examination are suggested. Prophylactic measures as f.e. Vitamin E administration are briefly mentioned. Finally, ophthalmological treatment is critically evaluated. An efficiency of coagulation has not yet been proven. An uncomplicated retinal detachement can be treated with conventional retinal surgery if it does not regress spontaneously during the course of active ROP. Chances to gain visual benefit from extreme vitreo-retinal surgery of endstage RLF with total retinal detachement cannot yet fully be estimated but seem to be very low.

Carbon Dioxide↗
PubMed1978

[Contribution to the formal pathogenesis of the classical seminoma. Early diagnosis from testicular biopsies?].

13 cases of seminoma of the testes were investigated in detail by means of light microscopy using paraffin and semithin sections. Paraffin sections were the basis for diagnosis, therapy, and prognosis. In semithin sectins, even individual seminoma cells within the seminiferous tubules were recognized by characteristic cytological features. In semithin sections also the development of the solid tumor from intratubular seminoma cells was elucidated. On the basis of our findings, the following concept of seminoma spread may be advanced: intratubular seminoma cells invade the lamina propria and gain access to to the interstitial tissue. Subsequent to the migration of seminoma cells, the tubules are smaller in diameter and contain only Sertoli cells. The seminoma cells in the interstitial tissue increase in number and build up the solid tumor.

Adult↗
PubMed1977

Chemotherapy in testicular tumors.

Surprisingly good clinical results are obtained by means of the so-called synchronized treatment with vincristine or bleomycin or adriamycin combined with Ifosfamid when cell-kinetic conditioning factors are taken into consideration. The results could neither be obtained with monotherapy nor by the aid of various combined therapies. Of 22 patients affected by metastasizing malignant testicular tumors a complete remission could be achieved in 14 continuing up to a period of 18 months. Six patients died. The answer to what extent these therapeutic results will be confirmed over a longer observation period, has, however, to be put off until a later date.

Bleomycin↗
PubMed1976

[Diabetic retinopathy: documentation, evaluation of its course and possibilities of treatment by photocoagulation].

Optimal documentation of retinal lesions by panorama fundus photographs is required for evaluation of the course of diabetic retinopathy (DR). The data are prepared for automatic storage and computation. The natural course of DR is occasionally characterized by remarkable spontaneous remissions. Therefore, unilateral treatment is needed to evaluate the efficacy of photocoagulation. The following preliminary results on 215 patients treated unilaterally with Xenon photocoagulation, and followed up for 6 months to 6 years, were statistically significant: marked decrease of intra- and epiretinal vessel new formations, prophylaxis of retinal neovascularization and vitreous hemorrhages, preservation of the macula and retention of visual acuity in diabetics below 60 years of age. The unpredictable rate of progression of DR in individual cases is responsible for occasional failures of photocoagulation.

Adult↗