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F Kauffman

Publications and source records attributed to F Kauffman.

9 recordsLinked to original sources
PubMed1993

Emergency department-based surveillance for syphilis during an outbreak in Philadelphia.

STUDY OBJECTIVE: To identify missed opportunities for syphilis treatment during an outbreak. DESIGN: Prospective prevalence survey. SETTING: Urban hospital emergency department. PARTICIPANTS: Nine hundred sixty-one persons aged 15 to 44 years seeking medical attention in the ED who were not suspected of having any sexually transmitted disease (STD) at the time of their visit. INTERVENTION: Serologic testing for syphilis and public health follow-up as needed. MEASUREMENTS AND MAIN RESULTS: Twenty-one non-STD patients (2%) had untreated early syphilis, and 22 (2%) had positive serology but were lost to follow-up. Among 271 STD patients seen in the ED during the same period, 15 cases (6%) were detected. We estimate that 80 or more additional untreated early syphilis cases would have been identified had all 15- to 44-year-old patients entering the ED been tested. The cost of screening was $251 per case detected. CONCLUSION: Patients not suspected of having any STD account for most early syphilis cases among all ED patients. Screening and on-site treatment for syphilis should be offered to all young adults seeking medical attention in the ED during syphilis outbreaks.

Adolescent↗
PubMed1987

Menadione causes selective toxicity to periportal regions of the liver lobule.

Infusion of increasing concentrations (0.2-1 mM) of the quinone, menadione, caused step-wise increases in oxygen uptake in perfused livers from fasted rats presumably due to oxygen-dependent redox cycling. Maximal increases in oxygen uptake of about 40 mumol/g/h were observed with 0.8 to 1.0 mM menadione. This increase in oxygen uptake was confined to periportal areas of the liver lobule suggesting that redox cycling due to menadione occurs exclusively in cells localized around the portal triad. After 60 min of infusion of menadione (1 mM), lactate dehydrogenase was released from the liver at rates between 60 to 70 U/g/h. Under these conditions, trypan blue was taken up by virtually all hepatocytes in periportal regions of the liver lobule. In contrast, dye was not taken up by cells in pericentral areas. It is concluded that menadione is selectively toxic to hepatocytes located in oxygen-rich periportal regions of the liver lobule.

Animals↗