Progressive supranuclear palsy (the Steele-Richardson-Olszewski syndrome) clinical and electrophysiological observations in eleven cases.
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Aged↗
Biomedical subjects
F Kee
Publications and source records attributed to F Kee.
Segregation analysis of colorectal cancer in Northern Ireland.
The genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of 305 pedigrees ascertained through a large population database. Two hundred and five of the pedigrees were ascertained through patients diagnosed with colorectal cancer before age 55, and 100 from patients diagnosed with colorectal cancer between the ages of 55 and 74. The analysis was carried out using the program POINTER. Using the joint-likelihood approach, the familial aggregation of colorectal cancer was compatible with the inheritance of a dominant gene. The gene frequency of the putative abnormal allele was 0.002 with a lifetime penetrance of 85%. However, under conditional likelihood, this mode of inheritance for a major gene was not favoured. The possible aetiologies of this paradoxical finding are discussed.
Adult↗
Clinical decision making in nephrology...renal function might not be the most important thing to measure.
There is evidence of substantial international and regional variation in the provision of Renal Replacement Therapy (RRT). Utilisation review studies and surveys of professional opinion have not yet disentangled the relative importance of renal and non-renal factors influencing key clinical decisions affecting access to RRT. Professional bodies have not produced prescriptive guidelines but the fundamental decision making areas relate to prognostication and the weighing up of patient utilities with or without particular forms of treatment. Increasingly techniques of quantitative judgment analysis are being used to clarify the decision drivers. There is a pressing need to understand and diagnose the decision making problem and the choice of intervention to improve clinical decision making must ultimately depend on clinical context.
Decision Making↗