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F Kehl

Publications and source records attributed to F Kehl.

5 recordsLinked to original sources
PubMed1988

[Ocular findings in tick borreliosis].

Tick-transmitted borreliosis is by no means a rare infectious disease. It is found especially in southern parts of Germany. Eyes are seldom affected. The disease can lead to nerve palsy of the eye muscles. One case of panophthalmitis and one of optic disk edema have been described. The authors found a bilateral palsy of the abducens nerve in one patient with tick-transmitted borreliosis. Motility normalized under therapy with highly-dosed penicillin.

Abducens Nerve↗
PubMed1986

Is there a pleiotropic response in barbiturate induction?

C57BL/6J mice were treated with barbitone, phenobarbitone, thiopentone and hexobarbitone, respectively, for a period of 6 days, and the resulting induction effects compared. Among parameters measured were metabolic rates for ethylmorphine, biphenyl, ethoxycoumarin and pentoxyresorufin. Effects of inducers were easily distinguishable from each other. No fixed proportions were seen among increased metabolic rates, but increases of relative liver weight, cytochrome P450 per g liver and pentoxyresorufin metabolism were accompanied by a corresponding decrease of biphenyl-2-hydroxylation. Doubling the dose (NMRI mice) of hexobarbitone and thiopentone increased inductive responses, but did not render them more similar to each other. Pentoxyresorufin metabolism was increased 5- to 30-fold, calculated per nmol cytochrome P450. The results argue against the existence of one pleiotropic response--at least in a strict sense--in barbiturate induction.

Animals↗