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Biomedical subjects

F Kempf

Publications and source records attributed to F Kempf.

At least 19 recordsLinked to original sources
PubMed1985

Coexistence of beta-1 and beta-2 adrenergic receptors in the human heart: effects of treatment with receptor antagonists or calcium entry blockers.

The properties of the binding of [125I]iodopindolol ([125I]IPIN) to beta adrenergic receptors on plasma membranes prepared from right atrial tissue removed during cardiac bypass surgery were investigated. Some of the patients from whom the tissue was removed had been treated before surgery with either a beta adrenergic receptor antagonist or a calcium entry blocker or both. The specific binding of [125I]IPIN to beta adrenergic receptors was saturable, stereoselective and rapidly reversible. Studies of the inhibition of the specific binding of [125I]IPIN by drugs selective for beta-1 or beta-2 adrenergic receptors suggested that both beta-1 and beta-2 adrenergic receptors are present in the tissue, with approximately 55% of the receptors having the properties of beta-2 adrenergic receptors. The density of receptors in patients not treated with beta adrenergic receptor antagonists or calcium entry blockers was approximately 80 fmol/mg of protein, whereas the density of beta adrenergic receptors in treated patients was increased by approximately 50%. The relative proportion of beta-1 to beta-2 adrenergic receptors in subjects treated with beta adrenergic receptor antagonists and/or calcium entry blockers was not significantly different from that in untreated subjects. Studies were also carried out with a limited number of samples of human ventricular muscle obtained from untreated subjects at the time of surgery. The density of receptors was lower than that observed in studies with atrial tissue. However, as with atrial tissue, approximately half of the receptors appeared to be beta-2 adrenergic receptors.

Adrenergic beta-Antagonists↗
PubMed1983

[Granulomatous colitis presenting as ischemic colitis].

The authors describe a case of granulomatous colitis mimicking a non gangrenous ischemic colitis. The radiological features are thumbprinting, ulcerations, then stenosis and sacculation. The resected specimen reveal some granuloma without necrosa.

Adult↗
PubMed1983

[Radiological aspects of gastric localizations of malignant non-Hodgkin's lymphoma. Apropos of 50 cases].

The authors describe radiological features of non Hodgkin's gastric lymphomas based on a study of 50 cases, with endoscopic correlation in 43 cases. Radiographic appearance is categorized as infiltrative (40 per cent), ulcerative (26 per cent), polypoid (10 per cent) and polymorphic (24 per cent). Gastric carcinoma is the most important differential diagnosis. Since staging, therapy and prognostic are different in these two diseases, accurate radiologic diagnosis is of particular importance. Combination of several peculiar radiologic signs suggest gastric lymphoma in 56 per cent of all the cases (16 per cent for endoscopy alone); this fact demonstrate the necessity of barium meal for a more accurate diagnosis of gastric lymphomas.

Adenocarcinoma↗
PubMed1983

[Radiological aspects of rectal and colonic localizations of malignant non-Hodgkin's lymphoma. Apropos of 30 cases].

The authors review radiological and endoscopical data of 30 patients with primary or secondary colonic and rectal non Hodgkin's lymphomatous involvement, and describe the radiologic pattern of this peculiar entity. Confirmation of the diagnosis is based in all cases on the pathological study of surgical specimens or per endoscopical biopsy. Eight patients (26%) presented non specific involvement secondary to small bowel or gastric localisation. The other patients (74%) had intrinsic lesions who may either remain localised (commonly endo-enteric type) or extend to whole of the colon (infiltrating type). After a description of the radiological features of these wide spectrum lesions, the authors consider the differential diagnosis and the respective contribution of colonic endoscopy and barium enema.

Adolescent↗
PubMed1982

[Meckel's diverticulum in the adult. Double-contrast study of 7 cases].

The authors report 7 cases of Meckel's diverticulum on a series of 500 double contrast small bowel enema (1,4%). In two cases, the diverticulum is not recognized by repletion study. So, they find that the double contrast small bowel enema is the most accurate method to detect a Meckel's diverticulum.

Adolescent↗
PubMed1980

[Radiological double contrast features of early lesions in Crohn's colitis (author's transl)].

We have performed 131 double contrast barium enemas in 81 cases of granulomatous colitis or ileocolitis. 53 cases showed "early lesions": Inflammatory mucosa, lymphoid hyperplasia, aphtoid or varioliform ulcers and primary complexes. In 39% "early lesions" were the only granulomatous lesions of the colon. Several types of "early lesions" may appear in the same patient. 18 patients were subjected to a series of double contrast barium enemas. The lesions progressed in 12 cases and regressed in 6 cases. "Early lesions" may develop into segmental coblestone pattern. The radiological findings were confirmed by endoscopy or operation in 91% of our cases. A perfect double contrast barium enema is necessary to detect these "early lesions" which are important for diagnosis, treatment and possibly even for the prognosis in this disease.

Barium Sulfate↗
PubMed1980

[The double contrast small bowel enema in Crohn's disease. 32 examinations (author's transl)].

The authors have performed 150 double contrast small bowel enema. The results of 32 radiological examinations in Crohn's disease are reported. Four elementary alterations of the mucosal pattern can be described:--folding modifications,--mucosal defects,--different ulcers,--association between defects and ulcers drawing the classic "cobblestone" pattern. The transmural lesion is evident by fistules, strings, dilatations and mesenteric retractions. The conventionnal radiologic examination of the small bowel is satisfactory to show the manifestations of transmural lesion; but the double contrast enema is clearly more performing to characteristic mucosal lesions. So it appears indispensable to use this method for exploration of every Crohn's disease, to complete the conventionnal repletion enema.

Adolescent↗
PubMed1980

[Radiological features of non-gangrenous ischaemic colitis (author's transl)].

The authors have performed barium enema in 22 cases of non gangrenous ischaemic colitis. The diagnosis was established on the clinical, endoscopic and radiological data. The barium enema's radiological features and their evolution are described in particular thumbprinting, ulcerations, stenosis and sacculations. All these radiological signs were confirmed by endoscopic investigation or pathological examination. Abdominal angiography are carried out in 10 cases. The preferential site of the lesions is the descending colon. The differential diagnosis with other colitis are discussed and the diagnosis is easier when the barium enema is performed soon.

Adult↗
PubMed1977

[An intramural hematoma of the small intestine, during anticoagulant therapy: radiological course. Concerning one case].

The authors present a case of intramural hematoma of the small intestines during anticoagulant treatment. With reference to this case, they study the frequency, etiopathogenesis and anatomy of this hematoma and particularly look at the radiological manifestations. In this respect they distinguish three stages in the evolution. The first, when the straight X-ray of the abdomen and barium followthrough demonstrate an axial stenosis of the small intestines with dilation of the proximal loops; the second (between the 7th and 20th days) when the loop affected by the hematoma takes on a characteristic "palissade" or "spring" -like sausage appearance; finally the third (after the 3rd week), when only thickening of the haustrations persists with progressive return to normal. The radiological diagnosis is discussed, not only with intramural hematomas of the small intestines of other etiologies (traumatic, during pancreatitis, during disorders in hemostatis), but also with conditions giving rise to similar radiological pictures: malabsorption, inflammatory conditions, etc.

Acenocoumarol↗
PubMed1977

[Acro-osteosclerosis in the course of sarcoidosis (author's transl)].

The authors report two cases of acro-osteosclerosis occurring during sarcoidosis. Condensation lesions involve above all the distal and proximal phalanges of the hands. Comparison of these cases with those in the literature indicates that these particular types of bone changes in association with sarcoidosis are more common than indicated in the studies of Jüngling (occurrence estimated at 54% of subjects suffering from sarcoidosis with bone localisations). This acro-osteosclerosis is however not specific to sarcoidosis. It is seen in patients suffering from rheumatoid arthritis, Hodgkin's disease and other haematological disorders. It has also been seen in normal individuals in X-rays taken at the time of a traumatic accident.

Arthritis, Rheumatoid↗