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Biomedical subjects

F Kessler

Publications and source records attributed to F Kessler.

26 records · Page 2Linked to original sources
PubMed1982

Endoscopic Nd: YAG laser therapy for carcinoma of the esophagus: a new palliative approach.

Since esophageal carcinoma is usually disseminated by the time diagnosis is made, treatment is often palliative. Symptomatic patients for whom no cure was possible were treated endoscopically with the Nd:YAG laser. Five patients aged 49 to 64 years, with tumors ranging in length from 5 to 11 cm, were treated. Significant clinical, endoscopic and radiographic improvements were noted in all patients. No major side effects were encountered. Endoscopic Nd:YAG laser therapy for carcinoma of the esophagus may provide a promising new approach for palliative treatment.

Carcinoma, Squamous Cell↗
PubMed1977

Double-blind one-year clinical study of fenoterol metered dose inhaler: preliminary results of a cooperative study.

As part of a controlled multi-center study 44 chronic asthmatics were treated for one year with either fenoterol (0.4 mg t.i.d. or q.i.d.) or isoproterenol (0.15 mg t.i.d. or q.i.d.) by metered dose inhaler. According to spirometric tests, fenoterol significantly improved pulmonary function until the end; isoproterenol became less effective after six months. Periodic global evaluations also gave no evidence of tolerance developing to femoterol. Side effects remained within acceptable limits.

Administration, Intranasal↗
PubMed1976

Fraction A: a new immunotherapeutic approach for ragweed pollinosis.

Fraction A, a concentrate derived from short ragweed extract by (NH4)2SO4 precipitation, contains all major allergens including antigen E. Therapeutic efficacy and safety of this alum-adsorbed product was evaluated in a multicenter double-blind clinical trial by comparing it to placebo in 131 randomly matched ragweed hay fever patients who were not treated for at least 1 year. Therapeutic response to fraction A injections was more significant than placebo (p less than 0.05) by investigators' evaluation, by average daily symptom score (1.097 vs. 1.378, p less than 0.05) during the peak ragweed season, or by average proportion of days in which medication was required (0.411 vs. 0.584, p = 0.01). Fraction A patients exhibited a significantly higher (p less than 0.0005) increase in hemagglutinating titer after treatment than placebo controls. Radioallergosorbent binding, evaluated in a subgroup of 31 patients before and after the ragweed season, was unchanged or decreased in 12 of 15 patients treated with fraction A. In contrast, 9 of 16 placebo-treated patients showed an increase in this index. Systemic effects were noted after 42 (1.5%) of 2.641 injections, while local reactions occurred at the rate of 2.3%. It is concluded that a single course of preseasonal immunotherapy wih alum-adsorbed fraction A is effective and relatively safe.

Adult↗
PubMed1975

Primary hyperparathyroidism in a referral hospital.

A series of 46 patients had a tissue diagnosis of primary hyperparthyrodism. Forty (88%) had a single adenoma, one had multiple adenomas; four exhibited parathyroid hyperplasia and one had carcinoma of the parathyroid. The incidence establishing the diagnosis has increased in recent years because of routine multichemistry screening for calcium. The most reliable "diagnostic" laboratory finding was an elevated serum calcium: 96 per cent of our patients had serum calcium above the upper limit of normal. Forty-one patients had lesions removed; parathyroid carcinoma (1), hyperplasia (3), and adenomas (37). Only two patients have presistent disease postoperatively: one with hyperplasia who apparently had an inadequate resection of her involved glands and one who had biopsy of an adenoma without further surgical management.

Adolescent↗
PubMedDate not supplied

[Unusual coincidence of dens aplasia and atlas malformation with early childhood spastic tetraparesis. Case report on the differential diagnosis of inflammatory atlantoaxial dislocation].

We report on the case of a 33 year old woman with acute tetraparesis and radiological evidence of atlantoaxial dislocation who had to undergo several attempts at osteosynthetic stabilisation of the cervical spine. She was afflicted with a spastic walk since the early years of childhood which had been explained by encephalitis after umbilical sepsis. The etiology of this severe and grave cervical instability however was found in a very rare congenital developmental disturbance of the occipitocervical passage with dystope os odontoid, extreme hypoplasia of the dens axis and additionally an osseous link between left processus transversus atlantis and occiput. Diagnostic problems arose from a simultaneous psoriasis, because a psoriatic cervical spondylitis seemed possible.

Adult↗
PubMedDate not supplied

[Thermometry in experimental inflammation. I. Studies on the circadian rhythm of the paw temperature in healthy rats and temperature behavior in acute inflammation after injection of kaolin, carrageenin and dextran].

Plantar paw skin temperature development was examined in 26 healthy male albino rats using Heimann's infrared thermometer KT 41. This examination was carried out on two groups of 12 and 14 male rats after intraplantar injection of kaolin, carrageenin, and dextran. Normal untreated animals showed a distinct circadian course of daily temperature, with minimal temperatures in the morning and maximal ones in the evening, and a mean difference of 3.9 degrees C. Among the phlogistic substances injected, kaolin proved to induce the most powerful increase in plantar skin temperature. It was followed by carrageenin; temperature increase in kaolin edema, however, started later than that induced by carrageenin. No pathological skin temperature increase was found after the injection of dextran. Physiological circadian temperature course, however, was modified in an undulating fashion. All phlogistic substances persistently disturbed thermoregulation in the inflamed rat paw. The comparison of temperature development in our experiments with paw swelling in similar models described in the literature did not always show a correspondence. Quantification of the intensity of experimental inflammations in animals using only a single parameter is thus not always adequate; under certain circumstances it can even lead to wrong conclusions. Nevertheless, infrared thermometry proved to be a very suitable method of estimating skin temperature as a parameter of inflammation.

Animals↗
PubMedDate not supplied

[Thermometry in experimental inflammation. II. Studies of the effect of local cold application on the skin temperature of the rat's paw in experimental inflammation].

In continuation of earlier thermometric investigations on experimental inflammations in rats we studied the effect of a single local cold application on paw skin temperature after injection of caolin , carrageenan and dextran. In all cooling experiments a highly significant drop of skin temperature of the inflamed paw could be demonstrated which came up to an average of 17 degrees C. However, the further course of skin temperature was very different. In caolin edema, the skin of the inflamed paw rewarmed quickly; after injection of carrageenan and dextran the skin temperature was significantly low after 60 min, but it exceeded the values later on. These results demonstrate that local cooling significantly influences experimental inflammations. Depending on different etiology and pathogenesis, however, the reaction of inflammation on cooling is very different.

Animals↗