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Biomedical subjects

F Kikuchi

Publications and source records attributed to F Kikuchi.

49 records · Page 3Linked to original sources
PubMed1984

A pathological study of fulminant hepatic disease.

Among 4,030 autopsies, 67 cases of fulminant hepatic failure were selected and studied from a pathological viewpoint. No sex difference in incidence was seen and the patients' age ranged very widely from 3 months to 78 years, showing comparatively high risk in the 20 s and 30 s in both sexes. Hepatitis virus was the most common cause, followed by toxic chemicals, shock, etc. Histopathological study revealed severe and extensive hepatic cell necrosis as the most conspicuous and common change of the liver, which was pathomorphologically quite similar to that experimentally produced by focal intravascular coagulation in rabbit. This evidence, as well as pathological findings of the other organs obtained at autopsy and the patients' reported clinical course, including laboratory data, were consistent with our proposal of a pathological disease entity, fulminant liver disease, which corresponds to the clinical symptom-complex known as fulminant hepatic failure. It is suggested that the characteristic feature of acute, severe and extensive hepatic cell necrosis which is seen in such cases is probably a result of an anoxic state caused in most instances by intrahepatic circulatory disturbances. Besides, we consider that fulminant liver disease can be regarded as a group of systemic diseases with the main focus of illness in the liver, rather than a specific disease of a single organ, the liver.

Adolescent↗
PubMed1984

[Right ventricular free wall imaging using thallium-201 exercise myocardial scintigraphy with special reference to coronary angiography].

Right ventricular wall images of ischemic heart disease were evaluated during exercise myocardial scintigraphy using thallium-201. Among 33 subjects, ten were normal controls, 11 had left coronary artery disease (LAD group), 12 had right coronary artery disease (RCA group), all of whom received exercise myocardial scintigraphy. The submaximal or symptom-related ergometer exercise test was performed by the protocol being with 25 watt (W) loading, and then increased by 25 W every 3 min, while 3 mCi thallium-201 were injected intravenously at the maximal exercise point. Early imaging was obtained 5 min after exercise; delayed imagings, 1 and 4 hours after exercise. Early imaging and delayed imaging at 4 hours after exercise were obtained in the AP, lateral, LAO 30 degrees, LAO 45 degrees, and LAO 60 degrees projections. Only the LAO 45 degrees was obtained for delayed imaging 1 hour after exercise. To assess the radioactivity in the right ventricular wall, with regions of interest (ROI) in the upper part of the right ventricle [RV (U)] lower part of the right ventricle [RV (L)] and the most radioactive region in the left ventricle [LV (P)], we calculated the count ratio of the RV(U) or RV(L) to the LV(P) and defined it as the RV uptake ratio [RV(U)/LV(P)] or [RV(L)/LV(P)]. The results obtained were as follows: There were no significant changes in the RV uptake ratio between the early and delayed images both in the control and LAD groups, but the RV uptake ratio decreased significantly in the delayed images compared with an early image in the RCA group.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1982

Epithelioid sarcoma. Enzyme histochemical and ultrastructural study.

A case of epithelioid sarcoma was studied by electron microscopy and by light and electron microscopic enzyme histochemistry comparing with several control soft tissues. In addition to previously reported ultrastructural features, such as abundant 10 nm cytoplasmic filaments, desmosome-like cell junctions and small cystic spaces surrounded by filopodia or microvilli of the tumor cells, we encountered 10 nm cytoplasmic filaments showing electron dense condensation with a concentrically oriented or whorled pattern and a finger-print-like arrangement and 5'-nucleotidase activity of tumor cell membrane. Among the control soft tissues, 5'-nucleotidase activity was found only in synovial and endothelial cells. Both tumor and synovial cells showed no activity of adenosine triphosphatase, while marked activity of the enzyme was found in endothelial cells. These results support the concept that epithelioid sarcoma is derived from mesenchymal cells undergoing differentiation toward synovial cells during neoplastic transformation.

Adenosine Triphosphatases↗
PubMed1981

Retinal amacrine cell involvement in Tay-Sachs disease.

Ultrastructural study of the retina from a patient with Tay-Sachs disease disclosed that amacrine cells as well as ganglion cells were loaded with numerous membranous cytoplasmic bodies, suggesting an accumulation of GM2 ganglioside, whereas the horizontal cells, bipolar cells, and photoreceptor cells were intact. Chromatography of lipids from the retina showed a prominent spot of GM2 ganglioside. These facts suggest that lipid metabolism in amacrine cells may be different from that in other retinal cells.

Child, Preschool↗