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Biomedical subjects

F Kissmeyer-Nielsen

Publications and source records attributed to F Kissmeyer-Nielsen.

At least 55 records · Page 3Linked to original sources
PubMed1978

On the mapping of PGM3, GLO and HLA.

In a combined Danish, American and Icelandic study, the odds for the orientation PGM3 :GLO:HLA-B:HLA-A versus GLO:HLA-B:HLA-A:PGM3 are estimated to be 75:1. The GLO:HLA recombination frequency is estimated at 5% for males and 12% for females. The recombination fraction for PGM3:GLO is 12--13% in males and is significantly higher in females (approximately free recombination). The findings are consistent with the large sex differences in recombination frequency between HLA and PGM3.

Epitopes↗
PubMed1978

Lymphocyte subpopulations in man. Expression of HLA-DR determinants on human T cells in infectious mononucleosis.

In a study of lymphocyte subpopulations in peripheral blood during infectious mononucleosis the lymphocytosis was found to be of T-cell origin (i.e. E-RFC), while the number of non T lymphocytes (i.e. EA-, EAC-RFC and SmIg + ve cells) was normal in 7 out of 8 patients. Ten patients were tested for the presence of HLA-DR determinants on their B and T cells and not only B lymphocytes but also a great part (31--75%) of T cells were lysed by the anti HLA-DR testsera, indicating that HLA-DR determinants are expressed on a population of T cells in IM patients. After recovery all patients were retested and showed a normal pattern of HLA-DR typing. This indicates an increase of HLA-DR antigens on T cells or a vigorous proliferation of a small DR-positive T-cell subpopulation during the acute stage of IM.

Absorption↗
PubMed1978

HLA histocompatibility antigens in open-angle glaucoma.

HLA-typing of 125 patients with open-angle glaucoma (glaucoma simplex) showed no statistically significant deviations from a control series of 1197 blood donors. Some earlier, but mutually inconsistent, reports contradict this result. In evaluating investigations of this kind care must be taken to avoid statistical pitfalls.

Aged↗
PubMed1977

MLC (HLA-D) typing: a family study.

The genetics of five HLA-D specificities (Dw1, Dw2, Dw3, Dw4 and Dw6) have been assessed in 21 normal families with four or more children. The HLA-D traits, as defined by typing response against homozygous typing cells, normally behave as dominant characters. The data support the concept of allelic factors. The locial flaw in the basic algorithm of MLC typing (HLA-D typing), i.e. to draw positive conclusions from negative observations, has been amply reinforced in the following studies. Five assignments could not be verified genetically under the assumption of dominant traits. Homozygous lack of specific response genes is among the mechanisms proposed as a cause for the phenomenon which has not yet been fully explained. The estimated magnitude of the frequency of false assignments is approximately 10%.

Adult↗
PubMed1977

On the HLA-B,D map distance.

HLA--A,--B,--C and--d typing and intra-familial MLC studies in 21 couples and their 91 children revealed three B, D recombinants in 165 informative haplotypes. This corresponds to a B,D map distance of 1.8 centiMorgans, which is somewhat higher than previous estimates based on intra-familial MLC chessboard experiments. All three recombinants are maternal.

Adult↗
PubMed1977

Education of lymphocytes in vivo following a transient take of a matched unrelated bone-marrow graft in man.

A patient suffering from aplastic anaemia was treated by bone-marrow transplantation from an ABO- and HLA-identical, MLC- and CML-negative, unrelated donor. MLC and CML became positive after transplantation indicating that a cellular immune response had developed against lymphocyte determinants not recognized prior to sensitization in vivo. Whether these determinants are governed by genes of the HLA region is unknown at present.

Adult↗
PubMed1977

Immunological diagnosis of rejection in human renal allotransplanted patients--a prospective study.

The object of this study has been to evaluate the recipient's immunological reactivity towards donor lymphocytes in relation to rejection episodes. All recipients (20) of local necrokidneys during 1976 were immunologically monitored immediately before transplantation and subsequently twice weekly for donor-specific complement dependent lymphocytotoxic (CDC) antibodies, antibody dependent cell-mediated cytotoxicity (ADCC) and cell-mediated lympholysis (CML). Experiments were performed until graft removal or dismissal (approx. 1100 patient days). Clinical diagnosis of rejection was made independently of immunological results. All clinically suspected rejection episodes, except one, were checked by microscopy. A positive CML-test accompanied 9 out of 11 rejection episodes; the test was negative on all other occasions. Positive CDC and ADCC tests exhibited no obvious correlation with rejection episodes: positive ADCC may be more frequent in clinically uncomplicated phases. Positive CML did not generally precede clinical graft rejection. Positive CML before transplantation was observed in two cases and was followed by irreversible, accelerated acute rejections. The CML-test may prove a reliable tool in rejection diagnosis and may yield results comparable with graft biopsy without inflicting any risk on the patient.

Antibodies↗
PubMed1977

Corneatransplantation and matching for HLA-A and B.

Analysis of 140 corneatransplantations performed without selection showed a significant correlation between the HLA-A and B match and the clinical outcome. Furthermore, a highly significant correlation was found between rejection episodes and a positive direct cell-mediated lympholysis.

Corneal Transplantation↗
PubMed1977

Patterns of immunological anti-donor reactivity in renal allotransplanted patients--a prospective study.

The immunological reactivity of 20 consecutive renal allotransplanted patients against donor lymphocytes were followed from the day of transplantation and subsequently twice weekly until dismissal or graftectomy. The investigations concerned Complement Dependent Cytotoxic (CDC) antibodies, Antibody Dependent Cell-Mediated Cytotoxicity (ADCC) and Cell-Mediated Lymphocytotoxicity (CML). Five patterns of immunological reactivity were observed parallelling the clinical courses. A specifically positive CML test was highly but not absolutely correlated to clinical graftrejection. Graftrejection was in general not preceeded by positive CML. The patterns of CDC and ADCC reactivity in relation to graftrejection were not evident.

Antibody-Dependent Cell Cytotoxicity↗
PubMed1977

HLA antigens in essential hypertension. Relation to familiar disposition and serum immunoglobulins.

HLA-typing was performed in 149 patients with essential hypertension, 86 males and 63 females. In 66 patients with significantly elevated serum levels of immunoglobulins, HLA-B27 was increased to 18%, from 8% in the controls (P less than 0.007). This was not significant when correcting the P-value for the number of antigens analyzed, but confirms reports of an association of this antigen with serum levels of immunoglobulins. HLA-Bw15 was found to be increased two-fold in patients with a family history of hypertension (P corrected less than 0.05) and in patients with autoantibodies (not significant). This is discussed in relation to the increase of Bw15 in juvenile diabetes and in Systemic Lupus Erythematosus, diseases in which vascular damage also occurs.

Epitopes↗
PubMed1976

Significance of HLA and blood-group incompatibility in spontaneous abortion.

The frequencies of antigen-incompatible matings within the HLA, Rhesus, Lutheran, MN, S. Lewis, Kell, P and Duffy systems were studied in 481 parents of karyotyped spontaneous abortuses. The results were compared with the calculated mating frequencies in control samples consisting of 1,197 (HLA) and 12,123 (the remaining eight systems) individuals, respectively. The only significant difference observed at the 5% level was an increased frequency of matins in which the mother was Lu (a+) and had a karyotypically abnormal abortus. It is concluded that antigen incompatibility between the parents within the nine systems studied is not important in the aetiology of early spontaneous abortion or causative in the origin of chromosome anomalies in the foetus.

Abortion, Spontaneous↗