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Biomedical subjects

F Koban

Publications and source records attributed to F Koban.

11 recordsLinked to original sources
PubMed1989

[The secretory performance of eccrine sweat glands from the nephrologic viewpoint--II: Middle molecules].

By means of gel-chromatographic investigations in the serum, sweat, urine and ultrafiltrate of healthy test persons, patients with renal insufficiency at the stage of the compensated and decompensated retention and of patients undergoing dialysis in the eccrine sweat substances in the area of so-called molecules of medium size from 1,100 to 2,050 Dalton are made evident. On account of the well-known heterogeneity of the gel-chromatographically separated fraction the concentration of the molecules of medium size is not unequivocally to be determined. It is, judged according to the peak hights of the chromatograms, less than 1/12 of the concentrations in the serum and the urine, but approximately corresponds to the content in the ultrafiltrate of patients undergoing haemodialysis. In patients with renal diseases the secretory possibility of the eccrine sudoriferous gland for molecules of medium size is not disturbed. A compensatory increased secretion of medium-size molecules via sweat in chronic renal insufficiency is not to be proved. The method of the gel-chromatography and the importance of the medium-size molecules for the pathogenesis of uraemia are critically discussed.

Chromatography, Gel↗
PubMed1988

[Nephrologic emergencies].

Nephrological emergencies are occurrences which may cause acute renal failure by various reasons. Useful support in diagnosis and introduction of treatment offers a classification in prerenal, renal and postrenal etiologic categories in which the prerenal type is most more frequent than the two others. Mitigated courses without decrease in urinary production are now observed increasingly. The clinical term acute emergency indicating a situation immediately life threatening refers in nephrology especially to pulmonary edema, hyperkalemia and hypertensive crisis respectively. Their life saving treatments are described.

Acute Kidney Injury↗
PubMed1988

Lipoprotein changes in familial hypercholesterolemia after extracorporeal immunoadsorption of low density lipoproteins.

The effects of extracorporeal immunoadsorption of LDL on the lipoprotein metabolism in two patients with familial hypercholesterolemia are reported. The immunoadsorbent consisted of F(ab')2 fragments of sheep anti-LDL antibodies, which had been coupled to Sepharose CL 4B. Within a time period of 3 to 3.5 hours a mean reduction of the level of total cholesterol by 76 +/- 4 p. cent could be obtained. The level of LDL cholesterol was reduced by 78 +/- 4 p. cent and the level of apo. B by 84 +/- 5 p. cent. Both LDL and VLDL were bound to the immunoadsorbent, while HDL was predominantly lowered by the plasma-dilution, which was in the order of 20 p. cent. The same was true for other serum proteins, not related to LDL or VLDL. The relative distribution of the different lipoprotein classes was again reached 3 days after the treatment, the initial lipid and apolipoprotein levels two to three weeks after the treatment. In a long-term therapy consisting of 45 treatments with a mean interval of 18 days between two treatments a mean cholesterol lowering of 42 p. cent could be achieved. No adverse effects and no sensitization to be heterologous protein were observed.

Adult↗
PubMed1988

[The elderly dialysis patient].

By the experience of two smaller dialysis centers the prognosis and problems of dialysis therapy in older patients are described. The age in the onset of dialysis treatment ranged from 45 to 54 years. In the beginning of dialysis the average life expectancy of older patients is markedly lower in comparison with younger patients, but remarkable in single cases with more than 4 and 5 years. The problems of adaptation and complications do require much attention and allowance. Contra-indications to dialysis therapy in older patients could not be explained. The demand for a stronger consideration of this patient group in planning of dialysis capacity is established through an international comparison and a possible rehabilitation of the patients.

Aged↗
PubMed1987

[Treatment of chronic renal failure associated with hereditary acroosteolysis by repeated hemodialysis].

We report the case of a 22-year old male patient with terminal renal failure consecutive to hereditary osteolysis affecting the tarsal and carpal bones associated with chronic glomerulonephritis. This is one of the first cases where prolonged survival was obtained by repeated haemodialysis and kidney transplantation. The various clinical features of this syndrome are described, together with its possible repercussions on bone abnormalities induced by repeated haemodialysis of kidney transplantation.

Adult↗
PubMed1987

[Secretory performance of eccrine sweat glands from the nephrologic viewpoint].

The question is of nephrological interest, whether the secretory product of eccrine sudoriferous glands apart from the well known function for thermoregulation is useful as excretory product for the therapy of renal insufficiency. In 17 healthy subjects and 39 patients with renal insufficiency thermal sweat was obtained by exposition in the sauna and four-tub bath. Control of the trainability of sweating in 23 patients during six weeks in the Kneipp cure sanatory. For the daily fluid balance remarkable quantities of sweat could be achieved. The sweat performance is trainable. The content of soluta in the sweat of patients with renal insufficiency surmounts that of healthy test persons. The excretion of nitrogen metabolites, electrolytes and acidity is quantitatively different and is analysed individually. Apart from the reliable methods of the conservative and invasive therapy of the uraemia the thermically stimulated sweating can be recommended as an adjuvant therapeutic regime.

Acid-Base Equilibrium↗