PubMed Health⌕ Search

Biomedical subjects

F Kober

Publications and source records attributed to F Kober.

26 records · Page 2Linked to original sources
PubMed1990

[Malignant lymphomas of the thyroid gland].

In the period from 1957-1989 43 malignant lymphomas of the thyroid gland were treated in the surgical department of Kaiser Elisabeth hospital. 42 were classified as non-Hodgkin lymphomas and one as a Hodgkin lymphoma. The sex distribution was 32 women (mean age 70) to 11 men (mean age 72). The patients were divided into two groups according to postoperative management. First group (1957-1978): conventional irradiation. N = 24 patients, mean survival time 5 months (0-37 months). Second group (1979-1989): high voltage irradiation and/or chemotherapy. N = 19 patients, mean survival time 39 months (1-128 months). All patients in the first group died, whilst in the second group only 9 have died to date. Moreover, 9 of the 10 patients who are still alive are in full remission. Over the past 10 years we have achieved a clear improvement in survival time; this is a result of extended radicality of the surgical procedures, haematological staging and an improvement in the chemotherapy and irradiation regimens.

Adult↗
PubMed1990

[Prognostic factors in highly malignant thyroid tumors].

Patients diagnosed as suffering from highly malignant thyroid tumours die within a few months due to rapid tumour progression. Survival depends on some valuable prognostic factors, namely tumour size, lymph node involvement, metastatic status, fast tumour growth and preoperative N. recurrens paresis. Life expectation and life quality are dependent on the feasibility of radical surgical treatment. It is necessary to remove the whole tumour to improve the survival rate and to reduce the incidence of local recurrence. Some highly malignant thyroid tumours show a high chemosensitivity.

Adult↗
PubMed1990

[Reinterventions in anaplastic cancers and sarcomas of the thyroid gland].

In the years 1979-1988, operations were performed on 41 anaplastic carcinomas and 11 sarcomas of the thyroid gland. Out of these cases reoperation was indicated in 18 patients (34.6%): in 11 cases only a palliative tracheotomy could be done (group I), whilst in the remaining 7 patients surgical removal of the recurrent tumour was possible (group II). Analysis of group II patients revealed that the initial surgical intervention had been a macroscopically radical operation. The difference between the survival rates of both groups was highly significant (group I 64 days, group II 412 days mean survival). Despite the fatal prognosis of these highly malignant tumours, we conclude that reoperation for the removal of a recurrent tumour is advisable in those patients in whom the initial operation was a radical excision. Longer survival rates and improved quality of life were achieved. If the initial operation was merely palliative, then only a tracheotomy is the likely procedure in case of recurrence.

Aged↗
PubMed1989

["Secondary surgery" in the oncologic concept of malignant struma].

Between 1978-1987 a reoperation had to be performed on 115 patients with carcinoma of the thyroid gland due to oncologically inadequate initial surgery. In papillary carcinomas, the high percentage of T1-tumors (43.1%) were the reason for lack of prae- or intraop. diagnostic evaluation, with the follicular carcinomas the high percentage of borderline frozen section. With invasive carcinomas, residues of the tumor were found either in the remaining thyroid tissue or in the lymph nodes (20.8%) while no further tumor has been found in encapsulated carcinomas. The rate of recurrent nerve paralysis document right after reportation was 18%, and its frequency depended on the time interval between initial surgery and reoperation. With encapsulated carcinomas of the type T1 we would suggest not to consider a reoperation, because we do not expect intrathyreoidal metastasation nor tumor involved lymph nodes and the risk of causing a recurrent nerve paralysis by a reoperation is not justifiable.

Adenocarcinoma↗
PubMed1987

[Distant metastases of malignant thyroid cancer. A retrospective study of 892 cases].

In 892 patients with thyroid carcinoma, distant metastases developed in 151 cases, and these were classified according to conventional pathohistological types and--in particular--to the incidence of surgically treatable solitary sites. The aim of the present study was also to investigate whether the histological diagnosis is of value in predicting the pattern of metastatic spread. Distant metastases of anaplastic carcinoma and sarcoma were found most frequently in the lungs (70 out of 81 patients, this is 86%), with 4 cases being solitary tumors. Metastatic spread into the skeleton, however, occurred rarely (14 out of 81 patients, 17.3%), when compared with differentiated carcinoma (64.8%). Moreover, with the exception of 1 case, metastatic growth was not solitary but involved more areas in bone. On the other hand, the well differentiated carcinoma displayed a greater predilection for the metastatic spread to the skeleton: 35 cases of bone involvement were identified in 54 patients with distant metastases (64.8%), and out of these cases, 10 metastases were solitary. Metastatic spread into the lungs occurred less often (30 of the 54 patients, 55.5%) and always displayed a diffuse pattern or involved multiple sites. In some cases, solitary metastases of different histological types were also identified in other organs. Our findings suggest that the pathohistological classification appears to be of use in guiding the clinical approach to a curative extirpation of distant solitary metastases in selected patients.

Humans↗
PubMed1986

[The cold adenoma as a surgical indication in an endemic area: over- or underestimated?].

The retrospective analysis of 7016 operations of the thyroid (1978-1985) showed an increase of operations of cold nodules from 23% to 52%. The rate of malignancy of cold nodules decreased from 7.2% to 6.3%. But, the intensive operative management of cold nodules resulted in an increase of operations of low stage tumors. Therefore radical operation of thyroid tumors was possible in 68.3% of cases. An elevated rate of malignancy is observed, if a cold nodule is associated with the following criteria: solitary, solid, male patients, younger than 30 and older than 60 years.

Austria↗