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Biomedical subjects

F Kocsis

Publications and source records attributed to F Kocsis.

24 records · Page 2Linked to original sources
PubMedDate not supplied

[Effect of sodium fluoride on DNA metabolism during therapy for osteoporosis].

The influence of sodium fluoride therapy on semiconservative DNA-synthesis and DNA-excision repair was investigated in lymphocytes of the peripheral blood of 6 patients with osteoporosis. The daily dose of sodium fluoride was 25 mg in the first week, and subsequent 50 mg during a period of 15 to 37 weeks. No significant effect on the tested parameters was found in 5 subjects. One patient showed significantly inhibited DNA-repair in the lymphocytes up to the ninth week, but during subsequent therapy normal values were obtained in this patient also. In conclusion sodium fluoride seems to have no effect on DNA-metabolism in lymphocytes of patients with osteoporosis.

DNA↗
PubMedDate not supplied

[Mode of action of D-penicillamine in chronic polyarthritis. 2. Studies on DNA repair in synovial fluid cells following intra-articular administration of D-penicillamine].

6 patients with rheumatoid arthritis were treated intraarticularly with 50 or 100 mg D-Penicillamine. The influence of this substance on DNA repair in cells of synovial fluid was investigated. DNA repair was investigated by gradient centrifugation. 50 mg D-PA showed no effect, 100 mg D-PA a slight slowing of the DNA-rejoining till the native supercoiled DNA form.

Adult↗
PubMedDate not supplied

[DNA metabolism in lymphocytes of experimental subjects during thermotherapy (sauna, Turkish bath)].

The unprogrammed DNA synthesis (UDS) in the lymphocytes of the peripheral blood was significantly higher in regular sauna-users than in those who had not had a sauna for some time. Sedimentation velocity of the supercoiled DNA in the lymphocytes was decreased 1 h and 24 h after Turkish bath, but the difference from values before the bath was not statistically significant.

Adult↗
PubMedDate not supplied

[Studies on the possible influence of oxamethacin upon DNA synthesis, DNA reparation and the supercoiled structure of DNA is spleen cells of mice].

The action of Oxamethacin on the DNA metabolism in spleen cells of mice was investigated with "in vitro" and "in vivo" experiments. An in vitro incubation of cells with 1 microgram Oxamethacin/ml did not influence the replicative DNA synthesis. 10 micrograms/ml however inhibited 50% of DNA synthesis. Oxamethacin dispensed in vivo did not show this inhibition. DNA repair after UV as well as after gamma irradiation was not influenced by this substance. Also the reconstitution of the supercoiled form of the DNA after different damages was not affected by Oxamethacin.

Animals↗